Results 311 to 320 of about 9,130,139 (414)

Atypical Presentations of Huntington Disease-like 2 in South African Individuals. [PDF]

Mov Disord Clin Pract
Narotam-Jeena H, Guttman M, van Hillegondsberg L, van Coller R, Krause A, Carr J.   +5 more
europepmc   +1 more source

Investigation of four diagnostic methods to identify infectious ulcerative keratitis in horses in Colorado, USA

Equine Veterinary Education, EarlyView.
Summary Background Ulcerative keratitis in equine patients can result in keratomalacia and perforation. Prompt and accurate diagnostics are necessary for appropriate therapy and a favourable outcome. Objective To determine the diagnostic utility (specificity and speed) of four diagnostic methods for infectious ulcerative keratitis in the horse.
K. E. V. Jones, M. R. Lappin, J. B. Daniels, J. Sharp, J. Hawley, M. d. L. Henriksen   +5 more
wiley   +1 more source

Digital assessment of speech in Huntington disease. [PDF]

Front Neurol
Nunes AS, Pawlik M, Mishra RK, Waddell E, Coffey M, Tarolli CG, Schneider RB, Dorsey ER, Vaziri A, Adams JL.   +9 more
europepmc   +1 more source

Poster 6: Triglyceride-Lowering Effects of EPA in Individuals with Huntington Disease

, 2008
Robert Block, E. Ray Dorsey, Christopher A. Beck, Ira Shoulson   +3 more
openalex   +1 more source

Targeted protein degradation of PDE4 shortforms by a novel proteolysis targeting chimera

The FEBS Journal, EarlyView.
Here, we report KTX207, a previously undescribed cereblon‐based PDE4 PROTAC that can specifically target PDE4D shortform for degradation. We showed that KTX207 could improve selectivity, potency and enable a long‐lasting effect when used at a sub‐nanomolar concentration.
Yuan Yan Sin, Aoife Giblin, Aleksandra Judina, Punchita Rujirachaivej, Laura G. Corral, Eliza Glennon, Zhi Xian Tai, Tian Feng, Eduardo Torres, Alina Zorn, Julia Gorelik, Elka Kyurkchieva, Pa Thai Yenchitsomanus, Cathy Swindlehurst, Kyle Chan, David Stirling, George S. Baillie   +16 more
wiley   +1 more source

Racial Disparities in Time to Huntington Disease Diagnosis in North America: An ENROLL-HD Analysis. [PDF]

Neurol Clin Pract
Mendizabal A, Ogilvie AC, Bordelon Y, Perlman SL, Brown A.   +4 more
europepmc   +1 more source

Poster 17: Lifestyle Activity and the Age of Onset of Huntington Disease

, 2008
K. Trembath, Andrew Churchyard, Z. Horton, Lynette J. Tippett, Virginia M. Hogg, Richard Roxburgh, Dennis Velakoulis, V. Collins, Martin B. Delatycki   +8 more
openalex   +1 more source

Regulation of physiological and pathological condensates by molecular chaperones

The FEBS Journal, EarlyView.
Mounting evidence suggests that stress granules (SGs), dynamic membraneless compartments involved in cellular stress responses, can transition into pathological condensates upon improper disassembly. This review discusses the evidence supporting this notion.
Nadeen Akaree, Valentina Secco, Flonia Levy‐Adam, Amal Younis, Serena Carra, Reut Shalgi   +5 more
wiley   +1 more source

Age- and disease-related autophagy impairment in Huntington disease: New insights from direct neuronal reprogramming. [PDF]

Aging Cell
Luo C, Yang J.
europepmc   +1 more source

PI5P4K inhibitors: promising opportunities and challenges

The FEBS Journal, EarlyView.
Developing inhibitors is like climbing a steep, challenging mountain. PI5P4K inhibitors hold significant promise for the treatment of cancer, immune disorders, and neurological diseases. However, the path to success is fraught with hurdles, and researchers are therefore required to apply their expertise to overcome critical “checkpoints.” While some ...
Koh Takeuchi, Lisa Nagase, Shun Kageyama, Hirotaka Kanoh, Masashi Oshima, Aki Ogawa‐Iio, Yoshiki Ikeda, Yuki Fujii, Sei Kondo, Natsuki Osaka, Takeshi Masuda, Tsukasa Ishihara, Yoshikazu Nakamura, Yoshihisa Hirota, Takehiko Sasaki, Toshiya Senda, Atsuo T. Sasaki   +16 more
wiley   +1 more source