Results 331 to 340 of about 9,130,139 (414)

Type I interferon signalling and interferon‐responsive microglia in health and disease

The FEBS Journal, EarlyView.
Recent insights reveal that type I interferon (IFN‐I) signalling plays critical roles in the nervous system beyond antiviral defence. Dysregulated IFN‐I activity is increasingly linked to neurological dysfunction and neurodegeneration, with microglia as central mediators. This review explores the broader impact of IFN‐I signalling on the nervous system
Jose P. Lopez‐Atalaya, Aysha M. Bhojwani‐Cabrera   +1 more
wiley   +1 more source

Ascertainment of uninterrupted CAG repeat length and disease-modifying variants in fragment-based genetic testing for Huntington Disease. [PDF]

Genet Med Open
Findlay Black H, Kay C, Dawson J, Bortnick S, Javier K, Xia Q, Chau CH, Leavitt T, Arning L, Nguyen HP, Hayden MR.   +10 more
europepmc   +1 more source

A guide to heat shock factors as multifunctional transcriptional regulators

The FEBS Journal, EarlyView.
The heat shock factors (HSFs) are evolutionarily conserved transcription factors best known as regulators of molecular chaperone genes in response to heat shock and other protein‐damaging stresses. Vertebrate HSFs, HSF1‐5, HSFX, and HSFY, are implicated in various physiological and pathological processes, including organismal development and cancer ...
Hendrik S. E. Hästbacka, Alejandro J. Da Silva, Lea Sistonen, Eva Henriksson   +3 more
wiley   +1 more source

Therapeutic validation of MMR-associated genetic modifiers in a human ex vivo model of Huntington disease. [PDF]

Am J Hum Genet
Ferguson R, Goold R, Coupland L, Flower M, Tabrizi SJ.   +4 more
europepmc   +1 more source

In vivo and in silico models of Drosophila for Parkinson's disease

The FEBS Journal, EarlyView.
In vivo and in silico models of Drosophila offer valuable advantages in the generation, analysis, and interpretation of complex biological data, thereby significantly advancing our understanding of Parkinson's disease. Molecular‐level measurements and phenotypic data from Drosophila are extensively utilised in metabolic network modeling and artificial ...
Müberra Fatma Cesur, Rachel Strazdins, Souvarish Sarkar, Tunahan Çakır   +3 more
wiley   +1 more source

Dark Adaptometry and Optical Coherence Tomography Angiography in Huntington Disease. [PDF]

J Ophthalmic Vis Res
Shah A, Fuller S, Criswell S, Apte RS.
europepmc   +1 more source

A Scoping Review of the Lived Experiences of Individuals With Huntington's Disease, Their Informal Caregivers and Offspring

Journal of Advanced Nursing, EarlyView.
ABSTRACT Background Huntington's disease has a disruptive effect on entire families. While previous reviews have examined lived experiences of individuals with Huntington's Disease, their informal caregivers, or their offspring, none have provided a comprehensive overview that integrates these three perspectives. Design A scoping review. Aims Providing
Cathelijn Van Baar, Kristel Kalkers, Sascha Bolt, Raymund Roos, Robbert Gobbens   +4 more
wiley   +1 more source

Investigation of genetic disease-specific human ESC lines: human ESC model of Huntington disease

, 2009
David S. Cram, Jonathan C. Niclis, Yury Verlinsky, Alan Trounson   +3 more
openalex   +1 more source

No Right to an Open Future

Journal of Applied Philosophy, EarlyView.
ABSTRACT Liberals writing about the family frequently cite the child's ‘right to an open future’ in discussions of the ethics of parental decision‐making for young children. This purported right grounds certain claims on behalf of children in considerations related to their future autonomy.
Joseph Millum
wiley   +1 more source

Selective changes in vasopressin neurons and astrocytes in the suprachiasmatic nucleus of Prader–Willi syndrome subjects

Journal of Neuroendocrinology, Volume 37, Issue 5, May 2025.
Abstract The hypothalamic suprachiasmatic nucleus (SCN) hosts the central circadian pacemaker and regulates daily rhythms in physiology and behavior. The SCN is composed of peptidergic neuron populations expressing arginine vasopressin (AVP) and vasoactive intestinal polypeptide (VIP), as well as glial cells.
Felipe Correa‐da‐Silva, Jari B. Berkhout, Pim Schouten, Margje Sinnema, Constance T. R. M. Stumpel, Leopold M. G. Curfs, Charlotte Höybye, Ahmed Mahfouz, Onno C. Meijer, Alberto M. Pereira, Eric Fliers, Dick F. Swaab, Andries Kalsbeek, Chun‐Xia Yi   +13 more
wiley   +1 more source