Results 371 to 380 of about 9,130,139 (414)
Some of the next articles are maybe not open access.
Current Treatment Options in Neurology, 2006
Although available treatments for Huntington's disease (HD) are imperfect, thoughtful application can positively impact quality of life. Dopamine antagonists can provide control of the troublesome hyperkinetic movements. These agents can also diminish the frequency of hallucinations and delusions when symptoms of psychosis occur. Classical neuroleptics
openaire +3 more sources
Although available treatments for Huntington's disease (HD) are imperfect, thoughtful application can positively impact quality of life. Dopamine antagonists can provide control of the troublesome hyperkinetic movements. These agents can also diminish the frequency of hallucinations and delusions when symptoms of psychosis occur. Classical neuroleptics
openaire +3 more sources
2018
Huntington disease is a monogenic neurodegenerative disorder that displays an autosomal-dominant pattern of inheritance. It is characterized by motor, psychiatric, and cognitive symptoms that progress over 15-20 years. Since the identification of the causative genetic mutation in 1993 much has been discovered about the underlying pathogenic mechanisms,
Ghosh, R, Tabrizi, SJ
openaire +3 more sources
Huntington disease is a monogenic neurodegenerative disorder that displays an autosomal-dominant pattern of inheritance. It is characterized by motor, psychiatric, and cognitive symptoms that progress over 15-20 years. Since the identification of the causative genetic mutation in 1993 much has been discovered about the underlying pathogenic mechanisms,
Ghosh, R, Tabrizi, SJ
openaire +3 more sources
Clinical Neuroscience Research, 2001
Abstract Huntington's disease (HD) is an autosomal dominant progressive neuropsychiatric disorder, characterized by abnormalities of movement, emotion and cognition. The most important pathological feature is selective neuronal loss, primarily in the striatum and cerebral cortex. HD is caused by the expansion of a CAG trinucleotide repeat in the gene
Russell L. Margolis, Christopher A. Ross
openaire +2 more sources
Abstract Huntington's disease (HD) is an autosomal dominant progressive neuropsychiatric disorder, characterized by abnormalities of movement, emotion and cognition. The most important pathological feature is selective neuronal loss, primarily in the striatum and cerebral cortex. HD is caused by the expansion of a CAG trinucleotide repeat in the gene
Russell L. Margolis, Christopher A. Ross
openaire +2 more sources
Irritability in Huntington’s disease
Psychiatry Research, 2012Irritability is a frequent neuropsychiatric symptom in patients with Huntington's disease (HD). The Irritability Scale (IS) and the irritability factor of the Problem Behaviours Assessment (PBA) was used to assess irritability among 130 HD mutation carriers and 43 verified non-carriers. The IS was tested using receiver operating characteristic analysis
Erik J. Giltay +7 more
openaire +4 more sources
Huntington's disease: Brain imaging in Huntington's disease
2019Huntington's disease (HD) gene-carriers show prominent neuronal loss by end-stage disease, and the use of magnetic resonance imaging (MRI) has been increasingly used to quantify brain changes during earlier stages of the disease. MRI offers an in vivo method of measuring structural and functional brain change. The images collected via MRI are processed
Eileanoir B. Johnson, Sarah Gregory
openaire +2 more sources
The American Journal of Nursing, 1979
ted by both sexes. Each child of an afflicted parent has a 50 percent chance of inheriting the disease. This risk continues uninterrupted from one generation to the next. Occasionally, a parent dies before the age when the symptoms characteristically appear, and this may give the impression, incorrectly, that Huntington's disease has skipped a ...
Stipe J, White D, Van Arsdale E
openaire +3 more sources
ted by both sexes. Each child of an afflicted parent has a 50 percent chance of inheriting the disease. This risk continues uninterrupted from one generation to the next. Occasionally, a parent dies before the age when the symptoms characteristically appear, and this may give the impression, incorrectly, that Huntington's disease has skipped a ...
Stipe J, White D, Van Arsdale E
openaire +3 more sources
Huntington disease: new insights into molecular pathogenesis and therapeutic opportunities
Nature Reviews Neurology, 2020S. Tabrizi, M. Flower, C. Ross, E. Wild
semanticscholar +1 more source
Huntington disease: natural history, biomarkers and prospects for therapeutics
Nature Reviews Neurology, 2014C. Ross +14 more
semanticscholar +1 more source
Therapeutic approaches to Huntington disease: from the bench to the clinic
Nature reviews. Drug discovery, 2018N. Caron +4 more
semanticscholar +1 more source
Onconephrology: The intersections between the kidney and cancer
Ca-A Cancer Journal for Clinicians, 2021Mitchell H Rosner +2 more
exaly