Results 51 to 60 of about 9,201,415 (257)
Targeting Huntingtin Expression in Patients with Huntington's Disease.
New England Journal of Medicine, 2019 BACKGROUND Huntington's disease is an autosomal-dominant neurodegenerative disease caused by CAG trinucleotide repeat expansion in HTT, resulting in a mutant huntingtin protein.
S. Tabrizi +21 more
semanticscholar +1 more source
Palliative Care in Huntington Disease: Personal Reflections and a Review of the Literature
Tremor and Other Hyperkinetic Movements, 2017 Background Huntington disease is a fatal, autosomal dominant, neurodegenerative disorder manifest by the triad of a movement disorder, behavioral disturbances, and dementia.
Christopher G. Tarolli +2 more
doaj +1 more source
A Randomized, Double-blind, Placebo-Controlled Study of Latrepirdine in Patients With Mild to Moderate Huntington Disease. [PDF]
, 2013 BACKGROUND Latrepirdine is an orally administered experimental small molecule that was initially developed as an antihistamine and subsequently was shown to stabilize mitochondrial membranes and function, which might be impaired in Huntington disease ...
DE MICHELE, GIUSEPPE +4 more
core +1 more source
Parkinsonism with a Hint of Huntington’s from 29 CAG Repeats in HTT
Brain Sciences, 2019 Huntington’s disease is caused by at least 36 cytosine-adenine-guanine (CAG) repeats in an HTT gene allele, but repeat tracts in the intermediate range (27−35 repeats) also display a subtle phenotype. This patient had a slightly elongated CAG
Sipilä JOT
doaj +1 more source
Protein Aggregates and Polyglutamine Tracts In Neurodegenerative Disease [PDF]
, 2018 The incidence of neurodegenerative diseases such as Alzheimer\u27s Disease, Parkinson\u27s Disease, Huntington\u27s Disease and other Polyglutamine Diseases is projected to dramatically increase throughout the developed world, and yet the pathology of ...
Mack, John
core +1 more source
Huntington\u27s Disease--A Review [PDF]
, 2016 Huntington’s disease is degenerative and effects both cognitive and motor functioning, beginning in the 20s and continuing a decline for about two decades until death.
Dunn, Christen
core +1 more source
Frontiers in Physiology, 2023 Introduction: Huntington disease is an autosomal dominant neurodegenerative disorder which is caused by a CAG repeat expansion in the HTT gene that codes for an elongated polyglutamine tract in the huntingtin (HTT) protein.
Fanny L. Lemarié +4 more
doaj +1 more source
How young people find out about their family history of Huntington's disease [PDF]
, 2009 Family communication about adult-onset hereditary illness can be problematic, leaving some relatives inadequately informed or ignorant of their risk.
Forrest Keenan, Karen +4 more
core +1 more source
A Right to Choose?: Sex Selection in the International Context [PDF]
, 2007 While there is some debate among doctors, ethicists, and the general public about the level of medical necessity that should justify a sex-selection procedure, most accept that sex selection for medical reasons is beyond ethical reproach, and in some ...
Bumgarner, Ashley
core +2 more sources
Juvenile Huntington disease in Argentina
Arquivos de Neuro-Psiquiatria, 2015 We analyzed demographic, clinical and genetic characteristics of juvenile Huntington disease (JHD) and it frequency in an Argentinean cohort. Age at onset was defined as the age at which behavioral, cognitive, psychiatric or motor abnormalities ...
Emilia Mabel Gatto +7 more
doaj +1 more source