Results 51 to 60 of about 9,130,139 (414)

Palliative Care in Huntington Disease: Personal Reflections and a Review of the Literature

Tremor and Other Hyperkinetic Movements, 2017
Background Huntington disease is a fatal, autosomal dominant, neurodegenerative disorder manifest by the triad of a movement disorder, behavioral disturbances, and dementia.
Christopher G. Tarolli, Amy M. Chesire, Kevin M. Biglan   +2 more
doaj   +1 more source

Metabolic and transcriptomic analysis of Huntington's disease model reveal changes in intracellular glucose levels and related genes. [PDF]

, 2017
Huntington's Disease (HD) is a neurodegenerative disorder caused by an expansion in a CAG-tri-nucleotide repeat that introduces a poly-glutamine stretch into the huntingtin protein (mHTT).
Chaves, Gepoliano, Costa, Yvonne Da, Hadiprodjo, Hana, Pourmand, Nader, Rao, Namrata V, Tokuno, Zachary, Özel, Rıfat Emrah   +6 more
core   +2 more sources

Associations of Plasma Glutamatergic Metabolites with Alpha Desynchronization during Cognitive Interference and Working Memory Tasks in Asymptomatic Alzheimer’s Disease

Cells
Electroencephalogram (EEG) studies have suggested compensatory brain overactivation in cognitively healthy (CH) older adults with pathological beta-amyloid(Aβ42)/tau ratios during working memory and interference processing.
Vincent Sonny Leong, Jiaquan Yu, Katherine Castor, Abdulhakim Al-Ezzi, Xianghong Arakaki, Alfred Nji Fonteh   +5 more
doaj   +1 more source

Awareness Level of Huntington Disease: Comprehensive Analysis of Tweets During Huntington Disease Awareness Month

Computer Methods and Programs in Biomedicine Update, 2023
Background: Unawareness of Huntington disease is prevalent where patients might have a denial of illness, less reporting of symptoms such as changes in behavior or cognitive impairment, or poor coping with the disease.
Nawal H Alharthi, Eman M Alanazi, Xiaoyu Liu   +2 more
doaj  

Experience of experimental simulation of Huntington’s disease

Анналы клинической и экспериментальной неврологии, 2017
Huntingtons disease (HD) is an autosomal dominant neurodegenerativedisease characterized by choreic hyperkinesia, cognitivedecline, behavioral disorders, and progressive neuronaldeath affecting primarily the striatum.
A. V. Stavrovskaya, D. N. Voronkov, N. G. Yamshchikova, A. S. Ol’shanskiy, R. M. Khudoerkov, S. N. Illarioshkin   +5 more
doaj   +1 more source

A Randomized, Double-blind, Placebo-Controlled Study of Latrepirdine in Patients With Mild to Moderate Huntington Disease. [PDF]

, 2013
BACKGROUND Latrepirdine is an orally administered experimental small molecule that was initially developed as an antihistamine and subsequently was shown to stabilize mitochondrial membranes and function, which might be impaired in Huntington disease ...
DE MICHELE, GIUSEPPE, European Huntington's Disease Network, HORIZON Investigators of the Huntington Disease Study Group, SACCA', FRANCESCO, SALVATORE, ELENA   +4 more
core   +1 more source

A genome wide dosage suppressor network reveals genetic robustness and a novel mechanism for Huntington's disease [PDF]

Nucleic Acids Research 45 (2017) 255-270, 2013
Mutational robustness is the extent to which an organism has evolved to withstand the effects of deleterious mutations. We explored the extent of mutational robustness in the budding yeast by genome wide dosage suppressor analysis of 53 conditional lethal mutations in cell division cycle and RNA synthesis related genes, revealing 660 suppressor ...
arxiv   +1 more source

Targeting Huntingtin Expression in Patients with Huntington's Disease.

New England Journal of Medicine, 2019
BACKGROUND Huntington's disease is an autosomal-dominant neurodegenerative disease caused by CAG trinucleotide repeat expansion in HTT, resulting in a mutant huntingtin protein.
S. Tabrizi, B. Leavitt, G. Landwehrmeyer, E. Wild, C. Saft, Roger A. Barker, Nick F. Blair, D. Craufurd, J. Priller, H. Rickards, A. Rosser, H. Kordasiewicz, C. Czech, E. Swayze, D. Norris, Tiffany L. Baumann, I. Gerlach, S. Schobel, E. Paz, Anne V Smith, C. Bennett, Roger M. Lane   +21 more
semanticscholar   +1 more source

Stimulation of S1PR5 with A-971432, a selective agonist, preserves blood-brain barrier integrity and exerts therapeutic effect in an animal model of Huntington's disease [PDF]

, 2018
Huntington's disease (HD) is themost common neurodegenerative disorder for which no effective cure is yet available. Although several agents have been identified to provide benefits so far, the number of therapeutic options remains limited with only ...
Amico, Enrico, Buttari, Fabio, Capocci, Luca, Castaldo, Salvatore, Di Pardo, Alba, Giovannelli, Alfredo, Madonna, Michele, Maglione, Vittorio, Marracino, Federico, Pepe, Giuseppe, van Bergeijk, Jeroen, van der Kam, Elizabeth   +11 more
core   +1 more source

A case report of juvenile Huntington disease

Journal of Pediatric and Neonatal Individualized Medicine, 2017
Huntington disease (HD) is a progressive neurodegenerative disorder, characterized by autosomal dominant inheritance, movement disorder, dementia, and behavioural disturbances.
Anita Choudhary, Priyanka Minocha, Sadasivan Sitaraman   +2 more
doaj   +1 more source