Results 111 to 120 of about 114,626,959 (164)

Huperzine A for Alzheimer's disease

Cochrane Database of Systematic Reviews, 2006
Alzheimer's disease (AD) has become a major public health problem around the world due to its increasing prevalence, long duration, caregiver burden, and high financial cost of care. The degeneration of acetylcholine-containing neurons in the basal forebrain has been implicated in the symptoms of AD.
J, Li, H M, Wu, R L, Zhou, G J, Liu, B R, Dong   +4 more
openaire   +3 more sources

Microbial transformation of (−)-Huperzine A

Tetrahedron Letters, 2010
Five products were yielded from the transformation of (−)-Huperzine A (1) by Streptomyces griseus CACC 200300. Their structures were determined as 16-hydroxyl huperzine A (2), 14α-hydroxyl huperzine A (3), huperzine A 8α,15α-epoxide (4), 13N-formyl huperzine A (5), and 13N-acetyl huperzine A (6) on the basis of their chemical and physical data.
Jungui Dai, Xinyuan Zhang
exaly   +2 more sources

Mechanism of inhibition of cholinesterases by huperzine A

Biochemical and Biophysical Research Communications, 1992
Huperzine A, an alkaloid isolated from Huperzia serrata was found to reversibly inhibit acetylcholinesterases (EC 3.1.1.7) and butyrylcholinesterases (EC 3.1.1.8) with on- and off-rates that depend on both the type and the source of enzyme. Long-term incubation of high concentrations of purified cholinesterases (1-8 microM) with huperzine A did not ...
Y, Ashani, J O, Peggins, B P, Doctor
openaire   +2 more sources

Synthesis of a hybrid analog of the acetylcholinesterase inhibitors huperzine A and huperzine B

Tetrahedron Letters, 2001
Abstract The synthesis of a new hybrid analog of the acetylcholinesterase (AChE) inhibitors huperzine A and B is reported. An intramolecular reductive dicarbonyl coupling was used as a key reaction for constructing the tetracyclic ring system.
V Rajendran, Suo-Bao Rong, Ashima Saxena, Bhupendra P Doctor, Alan P Kozikowski   +4 more
openaire   +1 more source

A Convergent Approach to Huperzine A and Analogues.

ChemInform, 2003
AbstractFor Abstract see ChemInform Abstract in Full Text.
Seán A, Kelly, Yann, Foricher, John, Mann, Jonathan M, Bentley   +3 more
openaire   +2 more sources

Synthesis of (±)-desamino huperzine A

Tetrahedron Letters, 2000
The first synthesis of desamino huperzine A 2 is described. Key steps are a double Michael addition into benzoquinone monoketal 4, a regiocontrolled double bond isomerisation and a novel pyridone synthesis involving a Michael addition of a ß-keto ester into acrylonitrile. (C) 2000 Elsevier Science Ltd.
Högenauer, Klemens, Baumann, Karl, Mulzer, Johann   +2 more
openaire   +1 more source

A total synthesis of (±)-huperzine A

Tetrahedron Letters, 1989
Abstract The first total synthesis of (±)-huperzine A, a new lycopodium alkaloid is described.
Ligang Qian, Ruyun Ji
openaire   +1 more source

Huperzia javanica as a Novel Source of Huperzine Alkaloids and Huperzine-producing Fungi

Indian Journal of Microbiology
Huperzine A (HupA) and huperzine B (HupB) are potent acetylcholinesterase inhibitor used widely for clinical treatment of Alzheimer's disease, which are mainly extracrted from natural populations of Huperzia species. This study aimed to the evaluate potential of producing Hup of native Huperzia javanica species collected in Vietnam as well as identify ...
Thanh Thi Minh, Le, Ha Thanh, Pham, Ha Thi Thu, Trinh, Ngoc Tung, Quach, Tuyen Thi, Do, Quyet-Tien, Phi, Ha Hoang, Chu   +6 more
openaire   +2 more sources

A Formal Synthesis of (+)-Huperzine A

Tetrahedron, 2000
Abstract A new formal stereoselective synthesis of (+)-Huperzine A (1) was achieved using as a key step a palladium mediated annulation between 2-methylene-1,3-propanediol diacetate and (1R,2S)-2-phenylcyclohexanol derived β-ketoester 2c.
Arnaud Haudrechy, Christophe Chassaing, Claude Riche, Yves Langlois   +3 more
openaire   +1 more source

A combination of [+] and [−]-Huperzine A improves protection against soman toxicity compared to [+]-Huperzine A in guinea pigs

Chemico-Biological Interactions, 2013
The neuropathologic mechanisms after exposure to lethal doses of nerve agent are complex and involve multiple biochemical pathways. Effective treatment requires drugs that can simultaneously protect by reversible binding to the acetylcholinesterase (AChE) and blocking cascades of seizure related brain damage, inflammation, neuronal degeneration as well
Ying, Wang, Yanling, Wei, Samuel, Oguntayo, Bhupendra P, Doctor, Madhusoodana P, Nambiar   +4 more
openaire   +2 more sources