Results 51 to 60 of about 5,627 (246)

Biomarkers of Drug‐Induced Kidney Injury: Use in Clinical Trials and Recent Examples of Impact on Drug Development

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
This manuscript describes the scope of implementation and impact of a regulatory agency‐qualified panel of six urine biomarkers on drug development, the process for which was conducted and funded by the Critical Path Institute, the Foundation for the National Institutes of Health, and the United States Food and Drug Administration.
Tanja S. Zabka   +7 more
wiley   +1 more source

Pathological findings in acute and chronic copper toxicity in rainbow trout (oncorhynchus mykiss, walbaum 1792) occurred by copper sulfate pentahydrate [PDF]

open access: yesEurasian Journal of Veterinary Sciences
Aim: In this study, it was aimed an experimental model of acute and chronic copper toxicity in the form of rainbow trout with copper sulfate pentahydrate and investigate the clinic, macroscopic and microscopic findings.
Sema Öztürk, Hamdi Avcı
doaj  

Renal amyloidosis in childhood. An overview of the topic with 25 years experience

open access: yesThe Turkish Journal of Pediatrics, 1995
Amyloidosis is a heterogeneous group of diseases characterized by extracellular accumulation of an eosinophilic, hyalin and proteinaceous material containing mucopolysaccharide substance in various tissues and organs.
K Tinaztepe
doaj  

Szóján előforduló Phoma-szerű gombák filogenetikai vizsgálata [PDF]

open access: yes, 2007
Vizsgálataink során a szóján (Glycine max) előforduló Phoma-szerű gombák molekuláris taxonómiai vizsgálatát végeztük el genetikai markerek szekvenciáinak elemezésével.
Irinyi, László Miklós   +2 more
core  

Aquatic moss precipitates metals in the presence of a specific endophytic microbiome

open access: yesiMetaOmics, EarlyView.
Harnessing moss–microbe interactions for metal removal. Schematic representation of aquatic moss Warnstorfia fluitans and its microbial symbionts in the remediation of metal‐contaminated waters. Amplicon sequencing and advanced microscopy revealed microbial community composition and role of moss symbionts in metal accumulation within the moss tissues ...
Kaisa Lehosmaa   +15 more
wiley   +1 more source

Orthotrichum (Orthotrichaceae, Bryopsida) in Pakistan [PDF]

open access: yes, 2002
A first critical survey of the genus Orthotrichum in Pakistan is provided. The currently known geographical distributions of the species and their ecologies within Pakistan are discussed.
Gruber, Johann Peter   +1 more
core  

Microfracture for full‐thickness chondral lesions of the knee in elite athletes leads to high return‐to‐play rates

open access: yesKnee Surgery, Sports Traumatology, Arthroscopy, EarlyView.
Abstract Purpose Injuries to the knee are common in elite athletes and often involve damage to the articular cartilage. Given the high demands of elite sport, full‐thickness articular cartilage defects in the knee can be career‐limiting or threatening.
David J. Haslhofer   +6 more
wiley   +1 more source

Life under Climate Change Scenarios: Sea Urchins’ Cellular Mechanisms for Reproductive Success [PDF]

open access: yes, 2016
Ocean Acidification (OA) represents a major field of research and increased efforts are being made to elucidate its repercussions on biota. Species survival is ensured by successful reproduction, which may be threatened under detrimental environmental ...
Bögner, Desislava
core   +2 more sources

Spheroid‐based matrix‐induced autologous chondrocyte implantation combined with autologous bone grafting restores physiological cartilage and subchondral bone properties in osteochondral knee defects ‐ An MRI‐based analysis

open access: yesKnee Surgery, Sports Traumatology, Arthroscopy, EarlyView.
Abstract Purpose This study aimed to evaluate the radiological and patient‐reported outcome measures (PROMs) following spheroid‐based matrix‐induced autologous chondrocyte implantation combined with autologous bone grafting (MABCI) for the treatment of osteochondral defects of the knee.
Stephan Oehme   +7 more
wiley   +1 more source

Minced cartilage implantation provides comparable outcomes to autologous chondrocyte implantation (ACI) for knee cartilage lesions: A matched‐pair analysis

open access: yesKnee Surgery, Sports Traumatology, Arthroscopy, EarlyView.
Abstract Purpose To compare short‐term patient‐reported outcomes (PROMs) and revision rates between autologous hand‐minced cartilage implantation (MCI) and autologous chondrocyte implantation (ACI) for knee cartilage lesions. Methods All patients undergoing MCI or ACI at a single centre were retrospectively analysed from a prospectively maintained ...
Armin Runer   +6 more
wiley   +1 more source

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