Stem Cells and Extrusion 3D Printing for Hyaline Cartilage Engineering [PDF]
Cells, 2020 Hyaline cartilage is deficient in self-healing properties. The early treatment of focal cartilage lesions is a public health challenge to prevent long-term degradation and the occurrence of osteoarthritis.
Océane Messaoudi +5 more
doaj +3 more sources
Strategies to Convert Cells into Hyaline Cartilage: Magic Spells for Adult Stem Cells. [PDF]
Int J Mol Sci, 2022 Damaged hyaline cartilage gradually decreases joint function and growing pain significantly reduces the quality of a patient’s life. The clinically approved procedure of autologous chondrocyte implantation (ACI) for treating knee cartilage lesions has ...
Kurenkova AD +4 more
europepmc +2 more sources
Cells, 2021 Articular cartilage defects represent an inciting factor for future osteoarthritis (OA) and degenerative joint disease progression. Despite multiple clinically available therapies that succeed in providing short term pain reduction and restoration of ...
Hallie Thorp +5 more
doaj +2 more sources
Hyaline cartilage differentiation of fibroblasts in regeneration and regenerative medicine.
Development, 2022 Amputation injuries in mammals are typically non-regenerative; however, joint regeneration is stimulated by BMP9 treatment, indicating the presence of latent articular chondrocyte progenitor cells.
Yu L +16 more
europepmc +2 more sources
Pondering the Potential of Hyaline Cartilage-Derived Chondroprogenitors for Tissue Regeneration: A Systematic Review. [PDF]
Cartilage, 2021 Objective Chondroprogenitors have recently gained prominence due to promising results seen in in vitro and animal studies as a potential contender in cell-based therapy for cartilage repair. Lack of consensus regarding nomenclature, isolation techniques,
Vinod E +3 more
europepmc +2 more sources
Regeneration of hyaline-like cartilage in situ with SOX9 stimulation of bone marrow-derived mesenchymal stem cells. [PDF]
PLoS ONE, 2017 Microfracture, a common procedure for treatment of cartilage injury, induces fibrocartilage repair by recruiting bone marrow derived mesenchymal stem cells (MSC) to the site of cartilage injury.
Xiaowei Zhang +6 more
doaj +2 more sources
DDX5 inhibits hyaline cartilage fibrosis and degradation in osteoarthritis via alternative splicing and G-quadruplex unwinding. [PDF]
Nat AgingHyaline cartilage fibrosis is typically considered an end-stage pathology of osteoarthritis (OA), which results in changes to the extracellular matrix. However, the mechanism behind this is largely unclear.
Liu Q +15 more
europepmc +2 more sources
Glycosaminoglycan, Antimicrobial Defence Molecule and Cytokine Appearance in Tracheal Hyaline Cartilage of Healthy Humans [PDF]
Journal of Functional Morphology and Kinesiology, 2022 Hyaline cartilage is an important tracheal structure, yet little is known about its molecular composition, complicating investigation of pathologies and replacement options.
Arina Deņisova +2 more
doaj +2 more sources
Is thickened hyaline cartilage on ultrasound a sign of osteoarthritis? A within-person, between-joint pilot study [PDF]
BMC RheumatologyObjective To determine whether the presence of conventional radiography (CR)-detected osteophytes is associated with focal thickening of the hyaline cartilage by ultrasound (US) in the same area of the metacarpal head in a within-person, between-joint ...
Edoardo Cipolletta +4 more
doaj +2 more sources
Transcriptomic and Proteomic Analyses Reveal the Potential Mode of Action of Chondrocyte Sheets in Hyaline Cartilage Regeneration. [PDF]
Int J Mol Sci, 2019 Chondrocyte sheet transplantation is a novel and promising approach to treating patients who have cartilage defects associated with osteoarthritis. Hyaline cartilage regeneration by autologous chondrocyte sheets has already been demonstrated in clinical ...
Toyoda E +9 more
europepmc +2 more sources