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Hyaluronan Synthases Posttranslational Regulation in Cancer
2014Hyaluronan (HA) is a critical component of cancer microenvironment that is known to increase tumor progression and aggressiveness. The synthesis of HA starts from the cytosolic precursors UDP-N-acetylglucosamine and UDP-glucuronic acid. These two sugar nucleotides have several functions in addition to glycoconjugate synthesis and glucuronidation ...
VIGETTI, DAVIDE, PASSI, ALBERTO
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Molecular Cloning of Human Hyaluronan Synthase
Biochemical and Biophysical Research Communications, 1996We report here the cDNA sequence of human hyaluronan synthase. The cDNA clone was isolated from a human fetal brain cDNA library by screening with a DNA probe generated from the coding sequence of murine hyaluronan synthase. It contains a 2107 bp cDNA insert which is composed of a 1629 bp open reading frame and a short segment of the 3'-untranslated ...
Koji Kimata, Naoki Itano
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Hyaluronan synthase expression in ovarian cancer
Oncology Reports, 2004To determine if the immunohistochemical expression of hyaluronan synthase (HAS) correlates with the clinicopathological manifestations or clinical outcomes of ovarian carcinoma, sections of tumor tissue from 33 ovarian cancer patients were immunostained by the avidin-biotin-peroxidase complex method using anti-HAS1, anti-HAS2, anti-HAS3 and anti-CD44 ...
Tameko Kishida +7 more
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Hyaluronan Synthases in Normal and Regenerating Joint Cartilage
Cells Tissues Organs, 2003Repair of full thickness joint cartilage defects is within reach of routine clinical practice. The quality of regenerating hyaline cartilage, however, is difficult to assess. Synthesis of an extracellular matrix with high hyaluronan content is crucial for its metabolic and functional properties.
Mrosek, Eike Herbert +3 more
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A Nonradioactive Method to Measure Hyaluronan Synthase Activity
2021Hyaluronan (HA) is a component of the extracellular matrix that is involved in many physiological and pathological processes. As HA modulates several functions (i.e., cell proliferation and migration, inflammation), its presence in the tissues can have positive or negative effects.
Evgenia Karousou +3 more
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Regulation of hyaluronan synthases in mouse uterine cervix
Biochemical and Biophysical Research Communications, 2005We examined the expression pattern of hyaluronan synthase (HAS) mRNAs in the uterine cervix of pregnant mice. The expression levels of HAS-1 and -2 mRNAs peaked at delivery, whereas that of HAS-3 mRNA peaked on the 15th day of pregnancy. The regulation of HAS mRNA expression was examined in pregnant mouse uterine cervical fibroblasts. The expression of
Tomohiro Sakuta +2 more
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2009
Hyaluronan (HA) is a polysaccharide composed of repeating GlcNAcβ(1 → 4)- GlcUAβ(1 → 3) disaccharide units. This polysaccharide has a molecular mass ranging from 103 to 107 Da, depending on the tissue source and physiological conditions. Three members of the HA synthase family, HAS1, HAS2 and HAS3, have been thus far identified in a wide variety of ...
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Hyaluronan (HA) is a polysaccharide composed of repeating GlcNAcβ(1 → 4)- GlcUAβ(1 → 3) disaccharide units. This polysaccharide has a molecular mass ranging from 103 to 107 Da, depending on the tissue source and physiological conditions. Three members of the HA synthase family, HAS1, HAS2 and HAS3, have been thus far identified in a wide variety of ...
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Hyaluronan synthase expression in pleural malignant mesotheliomas
Virchows Archiv, 2005Hyaluronan (HA) is thought to play several important roles in tumor growth, tumorigenicity, and tumor dissemination and metastasis. Recently, three isoforms of hyaluronan synthase (HAS) have been cloned. Our objective was to determine which of the HAS isoforms were expressed in pleural malignant mesotheliomas, the most representative lesion of HA ...
Koji Kimata +7 more
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Hyaluronan Synthases, Hyaluronan and Its CD44 Receptors in the Posterior Segment of Rabbit Eye
Ophthalmologica, 2005To understand the possible roles of the hyaluronan synthetase (HAS)/hyaluronan (HA)/CD44 signaling system in the posterior eye segment, we investigated the expression of rabbit HAS isoforms and CD44 mRNA by RT-PCR and the level of HA by using HA assay and immunohistochemistry. HA was detectable in vitreous, retina and choroid.
Masatoshi Murata, Saburo Horiuchi
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Applied Microbiology and Biotechnology, 2019
The molecular weight (Mw) of hyaluronic acid (HA) determines its suitability for medical and cosmetic applications. Here, we characterize in vitro and in vivo HA synthesis of streptococcal HA synthases (HASs) with a special focus on HA Mw. To date, four streptococcal HA producers are described (Streptococcus equi subsp. equi, S.
Sandra Schulte +6 more
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The molecular weight (Mw) of hyaluronic acid (HA) determines its suitability for medical and cosmetic applications. Here, we characterize in vitro and in vivo HA synthesis of streptococcal HA synthases (HASs) with a special focus on HA Mw. To date, four streptococcal HA producers are described (Streptococcus equi subsp. equi, S.
Sandra Schulte +6 more
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