Hyaluronan nanoscale clustering and Hyaluronan synthase 2 expression are linked to the invasion of child fibroblasts and infantile fibrosarcoma in vitro and in vivo [PDF]
Scientific Reports, 2022 Infantile fibrosarcoma is a rare childhood tumour that originates in the fibrous connective tissue of the long bones for which there is an urgent need to identify novel therapeutic targets.
Joseph J. Tonge +7 more
doaj +3 more sources
Genetic Deficiency of Hyaluronan Synthase 2 in the Developing Limb Mesenchyme Impairs Postnatal Synovial Joint Formation [PDF]
BiomedicinesHyaluronan, a key component of the extracellular matrix, plays a crucial role in joint development and maintenance. In order to determine the role of hyaluronan function in joint development and homeostasis, conditional loss-of-function experiments of ...
Yingcui Li +10 more
doaj +3 more sources
4-Methylumebelliferone Enhances Radiosensitizing Effects of Radioresistant Oral Squamous Cell Carcinoma Cells via Hyaluronan Synthase 3 Suppression [PDF]
Cells, 2022 Radioresistant (RR) cells are poor prognostic factors for tumor recurrence and metastasis after radiotherapy. The hyaluronan (HA) synthesis inhibitor, 4-methylumbelliferone (4-MU), shows anti-tumor and anti-metastatic effects through suppressing HA ...
Kazuki Hasegawa +2 more
exaly +4 more sources
Expression and molecular characterization of an intriguing hyaluronan synthase (HAS) from the symbiont “Candidatus Mycoplasma liparidae” in snailfish [PDF]
PeerJBackground Hyaluronan synthases (HASs) are ubiquitous in living organisms, and the hyaluronic acid (HA) synthesized by them are important to their body and well used in medicine, cosmetics and other fields.
Lulu Guo +3 more
doaj +3 more sources
Attenuated Replication-Competent Herpes Simplex Virus Expressing an ECM-Modifying Transgene Hyaluronan Synthase 2 of Naked Mole Rat in Oncolytic Gene Therapy [PDF]
Microorganisms, 2023 Herpes simplex virus (HSV) has proven successful in treating human cancer. Since the approval of talimogene laherparepvec (T-VEC) in 2015, HSV has been thoroughly researched to discover novel mechanisms to combat cancer and treat other diseases.
Jussi Palomäki +7 more
doaj +2 more sources
Insights into substrate binding and utilization by hyaluronan synthase [PDF]
eLifeHyaluronan (HA), a heteropolysaccharide of alternating N-acetylglucosamine (GlcNAc) and glucuronic acid (GlcA), is an essential component of the vertebrate extracellular matrix.
Zachery Stephens +2 more
doaj +2 more sources
Bone quality relies on hyaluronan synthesis – Insights from mice with complete knockout of hyaluronan synthase expression [PDF]
Matrix Biology PlusBone consists of a complex mineralised matrix that is maintained by a controlled equilibrium of synthesis and resorption by different cell types. Hyaluronan (HA) is an important glycosaminoglycan in many tissues including bone.Previously, the importance ...
A. Saalbach +9 more
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Elevated expression of hyaluronan synthase 2 associates with decreased survival in diffusely infiltrating astrocytomas [PDF]
BMC Cancer, 2018 Background Diffusely infiltrating astrocytomas originate from astrocytic glial cells or their precursor cells and are the most common type of brain tumors in adults. In this retrospective study, we investigated the content of hyaluronan, its cell surface
Mari Valkonen +5 more
doaj +2 more sources
Type-3 Hyaluronan Synthase Attenuates Tumor Cells Invasion in Human Mammary Parenchymal Tissues [PDF]
Molecules, 2021 The microenvironment for tumor growth and developing metastasis should be essential. This study demonstrated that the hyaluronic acid synthase 3 (HAS3) protein and its enzymatic product hyaluronic acid (HA) encompassed in the subcutaneous extracellular ...
Wen-Jui Lee +11 more
doaj +2 more sources
Hyaluronic acid production and characterization by novel Bacillus subtilis harboring truncated Hyaluronan Synthase [PDF]
AMB Express, 2022 Key points The strains containing truncated forms of SeHAS enzysme are able to produce HA. The HA from all recombinant strains was the same and low Mw. Deletion of C-terminal region of SeHAS was not effective on Mw.
Fatemeh Sadat Amjad Zanjani +7 more
doaj +2 more sources