Results 21 to 30 of about 10,976 (205)

HYBID (alias KIAA1199/CEMIP) and hyaluronan synthase coordinately regulate hyaluronan metabolism in histamine-stimulated skin fibroblasts [PDF]

Journal of Biological Chemistry, 2020
Hiroyuki Yoshida, Yoko Endo, Keigo Kawabata   +2 more
exaly   +2 more sources

Mammalian Hyaluronan Synthases [PDF]

IUBMB Life, 2002
AbstractThree mammalian hyaluronan (HA) synthase genes, HAS1, HAS2, and HAS3, have been cloned and expressed, allowing the mechanisms for regulation of HA biosynthesis and function to be studied. The hyaluronan synthase (HAS) isoforms differ in kinetic characteristics and product size.
Naoki, Itano, Koji, Kimata
openaire   +2 more sources

Glucocorticoids Directly Affect Hyaluronan Production of Orbital Fibroblasts; A Potential Pleiotropic Effect in Graves’ Orbitopathy

Molecules, 2022
Orbital connective tissue expansion is a hallmark of Graves’ orbitopathy (GO). In moderate-to-severe active GO, glucocorticoids (GC) are the first line of treatment.
Erika Galgoczi, Monika Katko, Fruzsina Reka Papp, Robert Csiki, Sara Csiha, Annamaria Erdei, Miklos Bodor, Bernadett Ujhelyi, Zita Steiber, Ferenc Gyory, Endre V. Nagy   +10 more
doaj   +1 more source

Mycobacteria exploit host hyaluronan for efficient extracellular replication. [PDF]

PLoS Pathogens, 2009
In spite of the importance of hyaluronan in host protection against infectious organisms in the alveolar spaces, its role in mycobacterial infection is unknown.
Yukio Hirayama, Mamiko Yoshimura, Yuriko Ozeki, Isamu Sugawara, Tadashi Udagawa, Satoru Mizuno, Naoki Itano, Koji Kimata, Aki Tamaru, Hisashi Ogura, Kazuo Kobayashi, Sohkichi Matsumoto   +11 more
doaj   +1 more source

Connective tissue growth factor mediates bone morphogenetic protein 2-induced increase in hyaluronan production in luteinized human granulosa cells

Reproductive Biology and Endocrinology, 2022
Background Hyaluronan is the main component of the cumulus-oocyte complex (COC) matrix, and it maintains the basic structure of the COC during ovulation.
Hsun-Ming Chang, Long Bai, Yi-Min Zhu, Peter C. K. Leung   +3 more
doaj   +1 more source

Chlorination and oxidation of heparin and hyaluronan by hypochlorous acid and hypochlorite anions: effect of sulfate groups on reaction pathways and kinetics. [PDF]

, 2013
Hypochlorous acid (HOCl), produced in inflammatory conditions by the enzyme myeloperoxidase, and its anion hypochlorite (OCl(-)) exist in vivo at almost equal concentrations.
Parsons, BJ, Akeel, A, Sibanda, S, Paterson, AW, Martin, SW   +4 more
core   +1 more source

Salicylate suppresses the oncogenic hyaluronan network in metastatic breast cancer cells

Matrix Biology Plus, 2020
The oncogenic role of hyaluronan in several aspects of tumor biology has been well established. Recent studies by us and others suggest that inhibition of hyaluronan synthesis could represent an emerging therapeutic approach with significant clinical ...
Theodoros T. Karalis, Athanasios Chatzopoulos, Aikaterini Kondyli, Alexios J. Aletras, Nikos K. Karamanos, Paraskevi Heldin, Spyros S. Skandalis   +6 more
doaj   +1 more source

In vitro synthesis of heparosan using recombinant Pasteurella multocida heparosan synthase PmHS2 [PDF]

, 2009
In vertebrates and bacteria, heparosan the precursor of heparin is synthesized by glycosyltransferases via the stepwise addition of UDP-N-acetylglucosamine and UDP-glucuronic acid.
Kooy, F.K., Eggink, G., Springer, J., Chavaroche, A.A.E., Anaïs A. E. Chavaroche, Boeriu, C.G., Floor Kooy, Gerrit Eggink, Jan Springer, Carmen Boeriu   +9 more
core   +1 more source

Selective adhesion inhibition and hyaluronan envelope reduction of dermal tumor cells by cold plasma-activated medium

Cell Adhesion & Migration, 2023
The sensitivity to cold plasma is specific to tumor cells while leaving normal tissue cells unaffected. This is the desired challenge in cancer therapy. Therefore, the focus of this work was a comparative study concerning the plasma sensitivity of dermal
Anna-Christin Golz, Claudia Bergemann, Finja Hildebrandt, Steffen Emmert, Barbara Nebe, Henrike Rebl   +5 more
doaj   +1 more source

Requirement of Multiple Signaling Pathways for the Augmented Production of Hyaluronan by V-SRC [PDF]

, 2005
2005-06Malignant transformation of cells is frequently associated with an augmented production of hyaluronan and the subsequent formation of a hyaluronan-matrix.
Huang, Pengyu, Naito, Yuko, Suzuki, Noriko, Hasegawa, Hitoki, Iwamoto, Takashi, Sohara, Yasuyoshi, Hamaguchi, Michinari   +6 more
core   +1 more source