Melatonin promotes neuroblastoma cell differentiation by activating hyaluronan synthase 3‐induced mitophagy [PDF]
Cancer Medicine, 2019 Neuroblastoma is the second most common pediatric malignancy and has a high rate of spontaneous remission. Uncovering the mechanisms underlying neuroblastoma cell differentiation is critical for therapeutic purposes.
Wen‐Jui Lee +8 more
doaj +2 more sources
The Control and Importance of Hyaluronan Synthase Expression in Palatogenesis [PDF]
Frontiers in Physiology, 2013 Development of the lip and palate involves a complex series of events that requires the close co-ordination of cell migration, growth, differentiation and apoptosis.
Jennifer eGalloway +3 more
doaj +4 more sources
A Connecting Link between Hyaluronan Synthase 3-Mediated Hyaluronan Production and Epidermal Function [PDF]
International Journal of Molecular Sciences, 2022 Yoshito Takahashi +2 more
exaly +2 more sources
4-Methylumebelliferone Enhances Radiosensitizing Effects of Radioresistant Oral Squamous Cell Carcinoma Cells via Hyaluronan Synthase 3 Suppression [PDF]
Cells, 2022 Yocihiro Hosokawa +2 more
exaly +2 more sources
Structure, substrate recognition and initiation of hyaluronan synthase. [PDF]
Nature, 2022 Hyaluronan is an acidic heteropolysaccharide comprising alternating N-acetylglucosamine and glucuronic acid sugars that is ubiquitously expressed in the vertebrate extracellular matrix1. The high-molecular-mass polymer modulates essential physiological processes in health and disease, including cell differentiation, tissue homeostasis and angiogenesis2.
Maloney FP +9 more
europepmc +6 more sources
Synaptic Hyaluronan Synthesis and CD44-Mediated Signaling Coordinate Neural Circuit Development
Cells, 2021 The hyaluronan-based extracellular matrix is expressed throughout nervous system development and is well-known for the formation of perineuronal nets around inhibitory interneurons.
Emily S. Wilson, Karen Litwa
doaj +1 more source
HYBID (alias KIAA1199/CEMIP) and hyaluronan synthase coordinately regulate hyaluronan metabolism in histamine-stimulated skin fibroblasts [PDF]
Journal of Biological Chemistry, 2020 Yasunori Okada +2 more
exaly +2 more sources
Mammalian Hyaluronan Synthases [PDF]
IUBMB Life, 2002 AbstractThree mammalian hyaluronan (HA) synthase genes, HAS1, HAS2, and HAS3, have been cloned and expressed, allowing the mechanisms for regulation of HA biosynthesis and function to be studied. The hyaluronan synthase (HAS) isoforms differ in kinetic characteristics and product size.
Naoki, Itano, Koji, Kimata
openaire +2 more sources
Hydrocellular foam dressing promotes wound healing along with increases in hyaluronan synthase 3 and PPARα gene expression in epidermis. [PDF]
PLoS ONE, 2013 BackgroundHydrocellular foam dressing, modern wound dressing, induces moist wound environment and promotes wound healing: however, the regulatory mechanisms responsible for these effects are poorly understood. This study was aimed to reveal the effect of
Takumi Yamane +8 more
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Molecules, 2022 Orbital connective tissue expansion is a hallmark of Graves’ orbitopathy (GO). In moderate-to-severe active GO, glucocorticoids (GC) are the first line of treatment.
Erika Galgoczi +10 more
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