Hyaluronan synthase 1 (HAS1): A mysterious enzyme with unexpected functions [PDF]
Frontiers in Immunology, 2015 Hyaluronan synthase 1 (HAS1) is one of three isoenzymes responsible for cellular hyaluronan synthesis. Interest in HAS1 has been limited because its role in hyaluronan production seems to be insignificant compared to the two other isoenzymes, HAS2 and ...
Hanna eSiiskonen +3 more
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Structure, substrate recognition and initiation of hyaluronan synthase. [PDF]
Nature, 2022 Hyaluronan is an acidic heteropolysaccharide comprising alternating N-acetylglucosamine and glucuronic acid sugars that is ubiquitously expressed in the vertebrate extracellular matrix1. The high-molecular-mass polymer modulates essential physiological processes in health and disease, including cell differentiation, tissue homeostasis and angiogenesis2.
Maloney FP +9 more
europepmc +7 more sources
Hydrocellular foam dressing promotes wound healing along with increases in hyaluronan synthase 3 and PPARα gene expression in epidermis. [PDF]
PLoS ONE, 2013 BackgroundHydrocellular foam dressing, modern wound dressing, induces moist wound environment and promotes wound healing: however, the regulatory mechanisms responsible for these effects are poorly understood. This study was aimed to reveal the effect of
Takumi Yamane +8 more
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Hyaluronan Synthase 3 Regulates Hyaluronan Synthesis in Cultured Human Keratinocytes [PDF]
Journal of Investigative Dermatology, 2002 Three human hyaluronan synthase genes (HAS1, HAS2, and HAS3) have been cloned, but the functional differences between these HAS genes remains obscure. The purpose of this study was to examine which of the HAS genes are selectively regulated in epidermis.
Sayo, Tetsuya +7 more
openaire +3 more sources
Nanotherapy in Joints: Increasing Endogenous Hyaluronan Production by Delivering Hyaluronan Synthase 2 [PDF]
Advanced Materials, 2019 AbstractOsteoarthritis (OA) is a common joint degenerative disease that causes pain, joint damage, and dysfunction. External hyaluronic acid (HA) supplement is a common method for the management of osteoarthritis which requires multi‐injections. It is demonstrated that biodegradable mesoporous silica nanoparticles successfully deliver an enzyme ...
Huimin Li +11 more
openaire +6 more sources
Melatonin promotes neuroblastoma cell differentiation by activating hyaluronan synthase 3‐induced mitophagy [PDF]
Cancer Medicine, 2019 Neuroblastoma is the second most common pediatric malignancy and has a high rate of spontaneous remission. Uncovering the mechanisms underlying neuroblastoma cell differentiation is critical for therapeutic purposes.
Wen‐Jui Lee +8 more
doaj +2 more sources
The Control and Importance of Hyaluronan Synthase Expression in Palatogenesis [PDF]
Frontiers in Physiology, 2013 Development of the lip and palate involves a complex series of events that requires the close co-ordination of cell migration, growth, differentiation and apoptosis.
Jennifer eGalloway +3 more
doaj +4 more sources
A Connecting Link between Hyaluronan Synthase 3-Mediated Hyaluronan Production and Epidermal Function [PDF]
International Journal of Molecular Sciences, 2022 Hiroyuki Yoshida +2 more
exaly +2 more sources
Transcriptional regulation of the human hyaluronan synthase genes: focus on hyaluronan synthase 2 [PDF]
This thesis examines the transcriptional regulation of the human hyaluronan synthase (HAS) genes, with particular focus on hyaluronan synthase 2. The data details the reconstruction of the genomic structures of each HAS isoform for the first time, as well as analysis of the activity of each HAS proximal promoter.
Monslow, Jamie
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Synaptic Hyaluronan Synthesis and CD44-Mediated Signaling Coordinate Neural Circuit Development
Cells, 2021 The hyaluronan-based extracellular matrix is expressed throughout nervous system development and is well-known for the formation of perineuronal nets around inhibitory interneurons.
Emily S. Wilson, Karen Litwa
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