Results 1 to 10 of about 5,167 (169)

Has2 Regulates the Development of Ovalbumin-Induced Airway Remodeling and Steroid Insensitivity in Mice [PDF]

Frontiers in Immunology, 2022
HAS2 is a member of the gene family encoding the hyaluronan synthase 2, which can generate high-molecular-weight hyaluronan (HMW-HA). Our previous study identified HAS2 as a candidate gene for increased susceptibility to adult asthma.
Yukio Ishii, Masayuki Nakajima, Takumi Kiwamoto   +2 more
exaly   +5 more sources

LncRNA HAS2-AS1 Promotes Glioblastoma Proliferation by Sponging miR-137 [PDF]

Frontiers in Oncology, 2021
GBM (Glioblastoma multiform) is the most malignant tumor type of the central nervous system and has poor diagnostic and clinical outcomes. LncRNAs (Long non-coding RNAs) have been reported to participate in multiple biological and pathological processes,
Yalin Lu, Yalin Lu, Yalin Lu, Gaochao Guo, Rujun Hong, Rujun Hong, Rujun Hong, Xingjie Chen, Xingjie Chen, Xingjie Chen, Yan Sun, Yan Sun, Yan Sun, Fang Liu, Zhimeng Zhang, Xun Jin, Xun Jin, Xun Jin, Xun Jin, Jun Dong, Kai Yu, Kai Yu, Kai Yu, Xuejun Yang, Xuejun Yang, Xuejun Yang, Yang Nan, Yang Nan, Yang Nan, Yang Nan, Qiang Huang, Qiang Huang, Qiang Huang, Qiang Huang   +33 more
doaj   +3 more sources

HAS2-AS1 is a novel LH/hCG target gene regulating HAS2 expression and enhancing cumulus cells migration [PDF]

Journal of Ovarian Research, 2019
Background The cumulus expansion process is one of the LH mediated ovulatory processes. Hyaluronan synthase 2 (HAS2) regulates the synthesis of hyaluronic acid, the main component of the cumulus expansion process.
Yuval Yung, Libby Ophir, Gil M. Yerushalmi, Micha Baum, Ariel Hourvitz, Ettie Maman   +5 more
doaj   +3 more sources

The Transcription Factor C/EBPβ Promotes HFL-1 Cell Migration, Proliferation, and Inflammation by Activating lncRNA HAS2-AS1 in Hypoxia

Frontiers in Cell and Developmental Biology, 2021
ObjectiveRecent studies were widely concerned about the role of lncRNAs in hypoxic pulmonary hypertension (HPH). HAS2 was found significantly highly expressed in HPH, but the antisense of HAS2 (HAS2-AS1) has not been explored in HPH, providing a new ...
Xinmin Liu, Lin Lianjun, Liu Xinmin
exaly   +3 more sources

Targeting HAS2 to enhance anti-tumor immunity in pancreatic cancer via PD-L1 regulation [PDF]

Communications Biology
Pancreatic cancer is an aggressive malignancy with poor prognosis and limited treatment options. Recent advances in immunotherapy have shown potential for improving outcomes; however, therapeutic resistance remains a challenge.
Chuifang Kong, Yanchun Fang, Lili Shen, Zhihua Shui, Mengjie Lv, Xinyu Zhang, Hanmeng Xu, Xunxia Bao, Pengwei Cao, Wenjing Ding, Tengfei Yu, Shengming Ruan, Juan Ran, Jiangming Chen, Juling Wang, Dongsheng Hou, Fubao Liu, Yanping Wang, Qiong Li, Daoxiang Zhang   +19 more
doaj   +2 more sources

Performance of the AUB-HAS2 cardiovascular risk index in coronary artery disease: a multicenter retrospective cohort study [PDF]

Annals of Medicine
Background While the American University of Beirut (AUB)-HAS2 cardiovascular risk index has emerged as a novel tool for preoperative risk stratification, its performance specifically in coronary artery disease (CAD) patients warrants further validation ...
Xiaolin Li, Congying Wang, Haodong Jiang, Jia Zhu, Runzhe Wu, Yongquan Niu, Feiyu Chen, Yunpeng Jin   +7 more
doaj   +2 more sources

HAS2-Ezrin-ER axis plays a role in acquired antiestrogen resistance of ER-positive breast cancer

Frontiers in Pharmacology, 2022
The development of endocrine resistance is a major clinical problem in estrogen receptor-positive (ER+) breast cancer (BrCa) treatment, in which how cancer cells acquire resistance remains obscure.
Qian Guo, Cuixia Yang, Fen Tang
exaly   +3 more sources

Hyaluronic acid synthase 2 dysfunction exacerbates elastase-induced neutrophilic airway inflammation and emphysema in mice [PDF]

Frontiers in Immunology
Chronic obstructive pulmonary disease (COPD) is a progressive inflammatory lung disorder primarily caused by prolonged exposure to harmful substances, such as cigarette smoke. Hyaluronic acid synthase 2 (HAS2) synthesizes high-molecular-weight hyaluronic
Kengo Nishino, Takumi Kiwamoto, Masashi Matsuyama, Zhenting Wei, Sosuke Matsumura, Kenya Kuramoto, Yuki Yabuuchi, Kai Yazaki, Kazufumi Yoshida, Yosuke Matsuno, Yuko Morishima, Nobuyuki Hizawa   +11 more
doaj   +2 more sources

FGF9 Promotes Expression of HAS2 in Palatal Elevation via the Wnt/β-Catenin/TCF7L2 Pathway

Biomolecules, 2022
Background: Fgf9 mutation was found in cleft palate patients. Our previous study indicated that Fgf9 promotes timely elevation of palate by regulating hyaluronic acid (HA) accumulation at embryonic day 13.5 (E13.5).
Zhenqi Chen, Ruomei Li, Xiyu Ying
exaly   +3 more sources

AUB‐HAS2 Cardiovascular Risk Index: Performance in Surgical Subpopulations and Comparison to the Revised Cardiac Risk Index

Journal of the American Heart Association, 2020
Background The American University of Beirut (AUB)‐HAS2 Cardiovascular Risk Index is a newly derived index for preoperative cardiovascular evaluation. It is based on 6 data elements: history of heart disease; symptoms of angina or dyspnea; age ≥75 years;
Habib Dakik, Ahmad Msheik, Hani Tamim
exaly   +3 more sources