Results 1 to 10 of about 6,032 (200)
HAS2-AS1 is a novel LH/hCG target gene regulating HAS2 expression and enhancing cumulus cells migration [PDF]
Journal of Ovarian Research, 2019 Background The cumulus expansion process is one of the LH mediated ovulatory processes. Hyaluronan synthase 2 (HAS2) regulates the synthesis of hyaluronic acid, the main component of the cumulus expansion process.
Yuval Yung +5 more
doaj +4 more sources
FGF9 Promotes Expression of HAS2 in Palatal Elevation via the Wnt/β-Catenin/TCF7L2 Pathway
Biomolecules, 2022 Background: Fgf9 mutation was found in cleft palate patients. Our previous study indicated that Fgf9 promotes timely elevation of palate by regulating hyaluronic acid (HA) accumulation at embryonic day 13.5 (E13.5).
Xiyu Ying, Ruomei Li, Jiajun Shi
exaly +4 more sources
Has2 Regulates the Development of Ovalbumin-Induced Airway Remodeling and Steroid Insensitivity in Mice [PDF]
Frontiers in Immunology, 2022 HAS2 is a member of the gene family encoding the hyaluronan synthase 2, which can generate high-molecular-weight hyaluronan (HMW-HA). Our previous study identified HAS2 as a candidate gene for increased susceptibility to adult asthma.
Takumi Kiwamoto +2 more
exaly +5 more sources
Frontiers in Cell and Developmental Biology, 2021 ObjectiveRecent studies were widely concerned about the role of lncRNAs in hypoxic pulmonary hypertension (HPH). HAS2 was found significantly highly expressed in HPH, but the antisense of HAS2 (HAS2-AS1) has not been explored in HPH, providing a new ...
Xinmin Liu
exaly +3 more sources
Zhongguo linchuang yanjiu, 2023 Objective To analyze the diagnostic value of color Doppler ultrasound, serum hyaluronic alkane synthase 2 (HAS2)， a disintegrin and metalloproteinase domain 9 (ADAM9) and the combination in papillary thyroid microcarcinoma (PTMC). Methods Seventy-four
YU Jin, XU Xianzhao, YU Haixia, YANG Tianhuang, WU Aiqiang
doaj +2 more sources
Targeting HAS2 to enhance anti-tumor immunity in pancreatic cancer via PD-L1 regulation [PDF]
Communications BiologyPancreatic cancer is an aggressive malignancy with poor prognosis and limited treatment options. Recent advances in immunotherapy have shown potential for improving outcomes; however, therapeutic resistance remains a challenge.
Chuifang Kong +19 more
doaj +2 more sources
Performance of the AUB-HAS2 cardiovascular risk index in coronary artery disease: a multicenter retrospective cohort study [PDF]
Annals of MedicineBackground While the American University of Beirut (AUB)-HAS2 cardiovascular risk index has emerged as a novel tool for preoperative risk stratification, its performance specifically in coronary artery disease (CAD) patients warrants further validation ...
Xiaolin Li +7 more
doaj +2 more sources
HAS2-Ezrin-ER axis plays a role in acquired antiestrogen resistance of ER-positive breast cancer
Frontiers in Pharmacology, 2022 The development of endocrine resistance is a major clinical problem in estrogen receptor-positive (ER+) breast cancer (BrCa) treatment, in which how cancer cells acquire resistance remains obscure.
Qian Guo, Yiqing He
exaly +3 more sources
Hyaluronic acid synthase 2 dysfunction exacerbates elastase-induced neutrophilic airway inflammation and emphysema in mice [PDF]
Frontiers in ImmunologyChronic obstructive pulmonary disease (COPD) is a progressive inflammatory lung disorder primarily caused by prolonged exposure to harmful substances, such as cigarette smoke. Hyaluronic acid synthase 2 (HAS2) synthesizes high-molecular-weight hyaluronic
Kengo Nishino +11 more
doaj +2 more sources
Matrix Biology, 2022 : Hyaluronan (HA) is a ubiquitous extracellular matrix component playing a crucial role in the regulation of cell behaviors, including cancer. Aggressive breast cancer cells tend to proliferate, migrate and metastatize.
Ilaria Caon +2 more
exaly +2 more sources