Results 11 to 20 of about 5,167 (169)

Fibroblast Has2 limits acute heart failure following myocardial infarction in male mice [PDF]

Physiological Reports
Changes to the extracellular matrix support acute wound healing following myocardial infarction. Fibroblasts regulate the composition of the extracellular matrix, in part, by secreting hyaluronan. Details surrounding the regulation, source, and impact of
Danielle T. Little, Kenneth R. Brittian, Caitlin Howard, Emma Pendergraft, Casey Colley, Ning Chen, Yu Yamaguchi, Richa Singhal, Joseph B. Moore IV, Marcin Wysoczynski, Yibing Nong, Steven P. Jones   +11 more
doaj   +2 more sources

Impact of Prunus Cerasus on PGR and HAS2 in Cumulus Cells and Fertility Outcome [PDF]

Advanced Pharmaceutical Bulletin, 2016
Purpose: Cumulus cells have a critical role in normal oocyte development and fertilization. Prunus cerasus is an anthocyanin rich berry and performs strong antioxidant activity.
Fatemeh Namvar Vansofla, Leila Roshangar, Azadeh Montaseri, Jafar Soleimani Rad   +3 more
doaj   +4 more sources

Hyaluronic acid−CD44 signaling from decidual stromal cells orchestrates dNK1 differentiation and immune tolerance in early pregnancy [PDF]

Frontiers in Immunology
IntroductionSpontaneous abortion (SA) is closely associated with immune homeostasis of decidual natural killer (dNK) cells at the maternal-fetal interface, yet how decidual stromal cells (DSCs) educate NK cells remains incompletely understood.
Di Wang, Jiawei Zhu, Qingzhi Wang, Lingyun Shi, Yehua He, Zili Jin, Zili Jin, Wenjun Chen, Xiaocong Chen, Shenjun Chen, Hong Li, Ce Zhang, Rui Zhu, Rui Zhu   +13 more
doaj   +2 more sources

Helicobacter pylori activates histone lactylation to promote gastric cancer progression and immune evasion through the HAS2/c-MYC/PD-L1 axis [PDF]

Gut Microbes
Background Metabolic reprogramming and epigenetic alterations play important roles in driving tumor microenvironment (TME) remodeling and immune evasion in gastric cancer (GC). Histone lactylation links glycolytic metabolism to transcriptional regulation,
Han Chen, Yan Wang, Zizhuang Wang, Wei Su, Yuting Shao, Guoxin Zhang, Zi Wang, Yixin Ge, Xiaoying Zhou   +8 more
doaj   +2 more sources

Small extracellular vesicles derived from hair follicle neural crest stem cells enhance perineurial cell proliferation and migration via the TGF-β/SMAD/HAS2 pathway [PDF]

Neural Regeneration Research
Peripheral nerve defect repair is a complex process that involves multiple cell types; perineurial cells play a pivotal role. Hair follicle neural crest stem cells promote perineurial cell proliferation and migration via paracrine signaling; however ...
Yiming Huo, Bing Xiao, Haojie Yu, Yang Xu, Jiachen Zheng, Chao Huang, Ling Wang, Haiyan Lin, Jiajun Xu, Pengfei Yang, Fang Liu   +10 more
doaj   +2 more sources

Genetic Deficiency of Hyaluronan Synthase 2 in the Developing Limb Mesenchyme Impairs Postnatal Synovial Joint Formation [PDF]

Biomedicines
Hyaluronan, a key component of the extracellular matrix, plays a crucial role in joint development and maintenance. In order to determine the role of hyaluronan function in joint development and homeostasis, conditional loss-of-function experiments of ...
Yingcui Li, Alexander Tress, Peter Maye, Kemar Edwards, Asiona Findletar, Nathaniel A. Dyment, Yu Yamaguchi, David W. Rowe, Gengyun Le-Chan, Sunny S. K. Chan, Kevin W.-H. Lo   +10 more
doaj   +2 more sources

Increased SPHK1 and HAS2 Expressions Correlate to Poor Prognosis in Pancreatic Cancer [PDF]

BioMed Research International, 2021
Objective. SPHK1 and HAS2 have been reported to play important roles in tumorigenesis and development. However, their expression and prognostic value in pancreatic cancer (PC) remain unclear. This study is aimed at investigating the expression of SPHK1 and HAS2 on the prognosis of pancreatic cancer. Materials and Methods.
Mengsi Yu, Kainan Zhang, Song Wang, Li Xue, Zhaoyun Chen, Ning Feng, Conghua Ning, Lijuan Wang, Jing Li, Boke Zhang, Changcheng Yang, Zhaoxia Zhang   +11 more
openaire   +2 more sources

Color Doppler ultrasound combined with serum HAS2 and ADAM9 in diagnosis of papillary thyroid microcarcinoma

Zhongguo linchuang yanjiu, 2023
Objective To analyze the diagnostic value of color Doppler ultrasound, serum hyaluronic alkane synthase 2 (HAS2)， a disintegrin and metalloproteinase domain 9 (ADAM9) and the combination in papillary thyroid microcarcinoma (PTMC). Methods Seventy-four
YU Jin, XU Xianzhao, YU Haixia, YANG Tianhuang, WU Aiqiang
doaj   +1 more source

Natural Antisense Transcript for Hyaluronan Synthase 2 (HAS2-AS1) Induces Transcription of HAS2 via Protein O-GlcNAcylation [PDF]

Journal of Biological Chemistry, 2014
Changes in the microenvironment organization within vascular walls are critical events in the pathogenesis of vascular pathologies, including atherosclerosis and restenosis. Hyaluronan (HA) accumulation into artery walls supports vessel thickening and is involved in many cardiocirculatory diseases.
VIGETTI, DAVIDE, Deleonibus S, MORETTO, PAOLA, Bowen T, Fischer JW, Grandoch M, Oberhuber A, Love DC, Hanover JA, CINQUETTI, RAFFAELLA, KAROUSOU, EVGENIA, VIOLA, MANUELA, D'ANGELO, MARIA LUISA, Hascall VC, DE LUCA, GIANCARLO, PASSI, ALBERTO   +15 more
openaire   +3 more sources

Conserved miR-26b enhances ovarian granulosa cell apoptosis through HAS2-HA-CD44-Caspase-3 pathway by targeting HAS2 [PDF]

Scientific Reports, 2016
AbstractThe hyaluronan synthase 2 (HAS2)-hyaluronic acid (HA)-CD44-Caspase-3 pathway is involved in ovarian granulosa cell (GC) functions in mammals. HAS2 is a key enzyme required for HA synthesis and is the key factor in this pathway. However, the regulation of HAS2 and the HAS2-mediated pathway by microRNAs in GCs is poorly understood.
Jiying Liu, Fei Tu, Wang Yao, Xinyu Li, Zhuang Xie, Honglin Liu, Qifa Li, Zengxiang Pan   +7 more
openaire   +2 more sources