Results 41 to 50 of about 6,032 (200)

A novel mutation of Hyaluronan synthase 2 gene in Chinese children with ventricular septal defect.

PLoS ONE, 2014
As a major product of extracellular matrix (ECM), Hyaluronic acid (HA) is involved in early cardiac development and mainly synthesized by Hyaluronan synthase 2 (HAS2) during embryogenesis. Targeted deletion of HAS2 gene in mice led to obvious cardiac and
Xiaomei Zhu, Xiaopeng Deng, Guangying Huang, Jing Wang, Jingwen Yang, Si Chen, Xu Ma, Binbin Wang   +7 more
doaj   +1 more source

GNA14 stimulation of KLF7 promotes malignant growth of endometrial cancer through upregulation of HAS2

BMC Cancer, 2021
Background Endometrial cancer (UCEC) is one of the most common gynecological malignancies. We previously found that overexpression of G protein α subunit 14 (GNA14) promoted UCEC growth.
Jing Wang, Fei Teng, Hongxia Chai, Caixia Zhang, Xiaolei Liang, Yongxiu Yang   +5 more
doaj   +1 more source

Pan-cancer analysis reveals the potential of hyaluronate synthase as therapeutic targets in human tumors

Heliyon, 2023
Hyaluronic acid (HA) is a crucial component of the extracellular matrix, and its level of accumulation is related to the progression of various malignant tumors. In this study, a pan-cancer analysis of the three enzymes called hyaluronan synthases (HAS1,
Xunxia Bao, Juan Ran, Chuifang Kong, Zunxi Wan, Juling Wang, Tengfei Yu, Shengming Ruan, Wenjing Ding, Leiming Xia, Daoxiang Zhang   +9 more
doaj   +1 more source

3’UTR shortening of HAS2 promotes hyaluronan hyper-synthesis and bioenergetic dysfunction in pulmonary hypertension

, 2022
Pulmonary hypertension (PH) comprises a diverse group of disorders that share a common pathway of pulmonary vascular remodeling leading to right ventricular failure.
Howard J. Huang, Bum-Yong Kang, Trammell, Aaron, Thandavarayan, Rajarajan A, Huang, Howard J, Eva S. Nozik, Michael Hart, C, Ayed Allawzi, Jennifer L. Ingram, Rajarajan A. Thandavarayan, Jyothula, Soma S S K, Soma S.S.K. Jyothula, Samantha Yeligar, Ryan Smith, M, Victor Tseng, Allawzi, Ayed, Crotty, Kathryn, Roy L. Sutliff, Nozik, Eva S, Eric J. Wagner, Sutliff, Roy L, Collum, Scott D, Wagner, Eric J, C. Michael Hart, Aaron Trammell, Scott D. Collum, Karmouty-Quintana, Harry, Ingram, Jennifer L, Harry Karmouty-Quintana, Tseng, Victor, Kang, Bum-Yong, Kathryn Crotty, Jyothula, Soma SSK, Yeligar, Samantha, M. Ryan Smith   +34 more
core   +1 more source

Inhibition of HAS2 and hyaluronic acid production by 1,25-Dihydroxyvitamin D3 in breast cancer [PDF]

Oncotarget, 2020
1,25-Dihydroxyvitamin D3 (1,25D3) induces growth arrest and apoptosis in breast cancer cells in vivo and in vitro, however the exact mechanisms are unclear. Although the vitamin D receptor (VDR), a ligand dependent transcription factor, is required for growth regulation by vitamin D, the specific target genes that trigger these effects are unknown ...
Narvaez, Carmen J., LaPorta, Erika, Robilotto, Samantha, Liang, Jennifer, Welsh, JoEllen   +4 more
openaire   +2 more sources

HAS2-AS1 expression is decreased in SY and increases with increasing HAS2 transcript level.

, 2016
(A) Expression difference of HAS2-AS1 between SY group (n = 12) and no-SY (n = 33) group by 3’seq, p = 0.00105. (B) By RT-PCR, expression of HAS2-AS1 was decreased in SY group (n = 10), with trend toward statistical significance, p = 0.09067.
Helen E. Knaggs (3339903), Dale Kern (3339909), Rui Li (4631), Inbar Raber (3339906), Kun Qu (215447), Jin Xu (31283), Linna Guan (3339897), Howard Y. Chang (215450), Anne Lynn S. Chang (3339900), Robert C. Spitale (2350243), Ryan A. Flynn (3339912), Eduardo A. Torre (232023)   +11 more
core   +1 more source

The role of the multifaceted long non-coding RNAs: A nuclear-cytosolic interplay to regulate hyaluronan metabolism

Matrix Biology Plus, 2021
In the extracellular matrix (ECM), the glycosaminoglycan (GAG) hyaluronan (HA) has different physiological roles favouring hydration, elasticity and cell survival.
Arianna Parnigoni, Ilaria Caon, Paola Moretto, Manuela Viola, Evgenia Karousou, Alberto Passi, Davide Vigetti   +6 more
doaj   +1 more source

Attenuated Replication-Competent Herpes Simplex Virus Expressing an ECM-Modifying Transgene Hyaluronan Synthase 2 of Naked Mole Rat in Oncolytic Gene Therapy

Microorganisms, 2023
Herpes simplex virus (HSV) has proven successful in treating human cancer. Since the approval of talimogene laherparepvec (T-VEC) in 2015, HSV has been thoroughly researched to discover novel mechanisms to combat cancer and treat other diseases.
Jussi Palomäki, Kiira Kalke, Julius Orpana, Liisa Lund, Fanny Frejborg, Henrik Paavilainen, Hannu Järveläinen, Veijo Hukkanen   +7 more
doaj   +1 more source

HAS2 conditional Tg (cHAS2) mice.

, 2013
FLAG-tagged murine HAS2 cDNA was positioned downstream of the transgene unit, including the CAG promoter, a loxP sequence, the neo-resistance gene (Neo), the SV40 poly(A) signal (pA), and a second loxP sequence.
Yuichiro Kashima (385917), Shun'ichiro Taniguchi (385921), Naoki Itano (58610), Koji Kimata (58611), Atsushi Izawa (385919), Jun Koyama (385920), Uichi Ikeda (385922), Masafumi Takahashi (138865), Jun Nakayama (29611), Yuji Shiba (385918)   +9 more
core   +1 more source

Oocyte–cumulus cell interaction: a key factor in early embryo development

Biological Reviews, EarlyView.
ABSTRACT The evaluation of oocyte competence is a fundamental step in achieving successful outcomes following assisted reproduction techniques (ART). At present, however, conventional oocyte maturation assessment is carried out by morphological observation, which is a subjective method that does not consider molecular features.
Marc Torres‐Garrido, Marc Yeste, Yentel Mateo‐Otero   +2 more
wiley   +1 more source