Results 61 to 70 of about 5,167 (169)

A Soft Matrix Microenvironment Promotes Laterally Spreading Tumors via Oxidative Phosphorylation‐Dependent Cell Adhesion

Advanced Science, Volume 13, Issue 30, 28 May 2026.
Laterally spreading tumors (LSTs) are precancerous colorectal lesions characterized by a flat morphology. This study reveals a mechanochemical pathway through which a soft matrix microenvironment diminishes spatial constraints in intestinal adenomas. This process promotes deficiencies in tight junction proteins, mediated by the mechanoreceptor ADORA2B ...
Jiamin Zhong, Jingyi Lu, Haopeng Li, Jun Zhong, Xiaobei Luo, Yiyi Hu, Xianfei Wang, Pengfei Wang, Yanning Zhang, Zhenjiang Wang, Qiuhua Lai, Zhenyu Chen, Wenting Mi, Wang Tin San‐to, Weize Li, Shuping Tan, Qihong Cheng, Ruijia Li, Yida Nie, Side Liu, Bing Huang, Zelong Han   +21 more
wiley   +1 more source

Comparison of preoperative NT-proBNP and simple cardiac risk scores for predicting postoperative morbidity after non-cardiac surgery with intermediate or high surgical risk

Perioperative Medicine
Background Chronic heart failure (HF) is frequent in elderly patients undergoing non-cardiac surgery. Preoperative risk stratification is vital and can be achieved using simple clinical risk scores or preoperative N-terminal prohormone of brain ...
Götz Schmidt, Nora Frieling, Emmanuel Schneck, Marit Habicher, Christian Koch, Birgit Aßmus, Michael Sander   +6 more
doaj   +1 more source

Hyaluronan synthase-2 upregulation protects smpd3-deficient fibroblasts against cell death induced by nutrient deprivation, but not against apoptosis evoked by oxidized LDL

Redox Biology, 2015
The neutral type 2 sphingomyelinase (nSMase2) hydrolyzes sphingomyelin and generates ceramide, a major bioactive sphingolipid mediator, involved in growth arrest and apoptosis.
Sandra Garoby-Salom, Myriam Rouahi, Elodie Mucher, Nathalie Auge, Robert Salvayre, Anne Negre-Salvayre   +5 more
doaj   +1 more source

The Small Molecule H89 Facilitates Mesenchymal Stem Cell‐derived Extracellular Vesicle Release and Optimizes Therapeutic Efficacy in Liver Regeneration

Journal of Extracellular Vesicles, Volume 15, Issue 5, May 2026.
ABSTRACT The role of human umbilical cord mesenchymal stem cell‐derived extracellular vesicles (hUCMSC‐EVs) in liver regeneration is promising, yet their clinical translation is hampered by insufficient production. Current strategies targeting their secretion are inefficient and lack a clear mechanistic understanding.
Yu Fu, Yi Ma, Jiajun Zhang, Liwei Liang, Ting Li, Zeyi Guo, Zhongzhe Li, Lei Feng, Yi Wang, Guolin He, Shao Li, Yang Li, Xiaoping Xu, Hui Liao, Yi Gao   +14 more
wiley   +1 more source

Tanshinone IIA Protects Ischemia/Reperfusion-Induced Cardiomyocyte Injury by Inhibiting the HAS2/FGF9 Axis

Cardiology Research and Practice
Purpose. This study aimed to investigate the impacts of tanshinone IIA (Tan IIA) on ischemia/reperfusion (I/R)-induced cardiomyocyte injury in coronary heart disease (CHD), and to determine whether Tan IIA regulates myocardial cell injury induced by I/R ...
Yanzhe Wang, Weixin Sun, Le Shen, Peng Yu, Qiusheng Shen, Yaozhong Zhou, Lu Yao, Xiaohu Chen   +7 more
doaj   +1 more source

Cartilage-Specific Has2 Deletion Uncovers an Important Role for Hyaluronan in Cartilage and Joint Integrity

Biomedicines
Background: Hyaluronan (HA) is a critical extracellular matrix component that we have demonstrated to be important for embryonic endochondral bone formation and postnatal synovial joint formation, supporting normal articular cartilage (AC) architecture ...
Yingcui Li, Raymond Xue, Sean Congdon, Maria Abbazia, Tianhui Zhou, Tiffiny Wong, Kyle Vaccaro, Kemar Edwards, Alexander Tress, Riley Stevens, Yu Yamaguchi, Kevin W.-H. Lo   +11 more
doaj   +1 more source

A novel ZEB1/HAS2 positive feedback loop promotes EMT in breast cancer

Oncotarget, 2017
Cancer metastasis is the main reason for poor patient survival. Tumor cells delaminate from the primary tumor by induction of epithelial-mesenchymal transition (EMT). EMT is mediated by key transcription factors, including ZEB1, activated by tumor cell interactions with stromal cells and the extracellular matrix (ECM). ZEB1-mediated EMT and motility is
Preca, Bogdan-Tiberius, Bajdak, Karolina, Mock, Kerstin, Lehmann, Waltraut, Sundararajan, Vignesh, Bronsert, Peter, Matzge-Ogi, Alexandra, Orian-Rousseau, Véronique, Brabletz, Simone, Brabletz, Thomas, Maurer, Jochen, Stemmler, Marc   +11 more
openaire   +6 more sources

Effect of vasopressin on the expression of genes for key enzymes of interstitial hyaluronan turnover and concentration ability in WAG rat kidneys

Вавиловский журнал генетики и селекции, 2016
In mammals, arginine-vasopressin (AVP) is a major hormone involved in the regulation of renal water reabsorption, acting via an increase in the osmotic permeability of the collecting duct epithelium.
L. N. Ivanova, A. V. Babina, G. S. Baturina, L. E. Katkova   +3 more
doaj   +1 more source

Investigation of Hyaluronan Synthase 2 and CD44 immune reactivity as a biomarker to predict Progesterone-Resistant Endometrial Hyperplasia without atypia: A retrospective case-control study

Indian Journal of Pathology and Microbiology
Background/Aims: In our study, the effect of hyaluronan synthase 2 (HAS2) and CD44 immunoreactivity as a predictive biomarker in the prediction of progesterone-resistant endometrial hyperplasia (EH) cases without atypia was investigated.
Emine Boybay, Remzi Atilgan, Şehmus Pala, Tuncay Kuloğlu, Gökhan Artaş   +4 more
doaj   +1 more source

Increased HA/CD44/TGFβ signaling implicates in renal fibrosis of a Col4a5 mutant Alport mice

Molecular Medicine
X-linked Alport syndrome (XLAS) caused by X-linked COL4A5 gene mutation is a hereditary disease that affects mainly the kidney. XLAS patients, especially males whose single copy of the COL4A5 gene is disrupted, suffer from a life-threatening renal ...
Yantao Bao, Weiqing Wu, Jiyun Lin, Yuankai Yang, Sheng Lin, Jindi Su, Yueyuan Qin, Baojiang Wang, Shan Duan   +8 more
doaj   +1 more source