Results 71 to 80 of about 5,167 (169)

Interconnected feedback loops among ESRP1, HAS2, and CD44 regulate epithelial-mesenchymal plasticity in cancer

APL Bioengineering, 2018
Aberrant activation of epithelial-mesenchymal transition (EMT) in carcinoma cells contributes to increased migration and invasion, metastasis, drug resistance, and tumor-initiating capacity.
Mohit Kumar Jolly, Bogdan-Tiberius Preca, Satyendra C. Tripathi, Dongya Jia, Jason T. George, Samir M. Hanash, Thomas Brabletz, Marc P. Stemmler, Jochen Maurer, Herbert Levine   +9 more
doaj   +1 more source

Dual inhibition of FAS and HAS2/3 by 4-MU in Realgar-Coptis chinensis unveils a metabolic checkpoint for liver cancer therapy

Natural Products and Bioprospecting
Modern pharmacology has found that both Realgar and Coptis chinensis can induce apoptosis in tumor cells, and traditional Chinese medicine theory suggests the possibility of combining the two, however, the specific mechanisms involved have not been ...
Songtao Wu, Yingying Wang, Denghui Deng, Guohua Zheng, Hanxiang Mei, Cong Wang, Xiang Zheng, Chun Gui, Fei Liao, Meixian Xiang   +9 more
doaj   +1 more source

Piceatannol enhances hyaluronic acid synthesis through SIRT1-Mediated HAS2 upregulation in human dermal fibroblasts

Biochemistry and Biophysics Reports
Dermal fibroblasts play a crucial role in skin structure and function by producing hyaluronic acid. Piceatannol (PIC), a polyphenol abundant in passion fruit seeds, has been reported to activate sirtuin 1 (SIRT1).
Mizuki Yoshihara, Shinpei Kawakami, Yuko Matsui, Toshihiro Kawama   +3 more
doaj   +1 more source

Differential Regulation of Hyaluronan Synthesis by Three Isoforms of Hyaluronan Synthases in Mammalian Cells

Biomolecules
Hyaluronan (HA) is one of the crucial components of the extracellular matrix in vertebrates and is synthesized by three hyaluronan synthases (HASs), namely HAS1, HAS2, and HAS3.
Jie Wang, Zhikun Wu, Longtao Cao, Feng Long   +3 more
doaj   +1 more source

Bone quality relies on hyaluronan synthesis – Insights from mice with complete knockout of hyaluronan synthase expression

Matrix Biology Plus
Bone consists of a complex mineralised matrix that is maintained by a controlled equilibrium of synthesis and resorption by different cell types. Hyaluronan (HA) is an important glycosaminoglycan in many tissues including bone.Previously, the importance ...
A. Saalbach, M. Stein, S. Lee, U. Krügel, M. Haffner-Luntzer, K. Krohn, S. Franz, J.C. Simon, J. Tuckermann, U. Anderegg   +9 more
doaj   +1 more source

Prospective validation of the AUB-HAS2 cardiovascular risk index

European Heart Journal - Quality of Care and Clinical Outcomes, 2020
Habib A Dakik, Mahmoud Eldirani, Chris Kaspar, Omar Chehab, Ahmad Msheik, Maha Makki, Hani Tamim   +6 more
openaire   +2 more sources

The correlation between cumulus oophorous cells and their gene expression with human embryo potential serves as a prognostic non-invasive indicator for ICSI success

SVU - International Journal of Medical Sciences
Background: Cumulus cells (CCs) are not only solid structural cells that surround the oocyte, but also CCs play a major role in the differentiation and maturity of the oocyte. The gene expression profile of CCs reflects the actual activity of these cells.
Mahmoud Souliman Iwes , Ahmed Esmat Abdellah , et all.   +2 more
doaj  

HAS2 Gene [PDF]

, 2020
openaire   +1 more source

Alpha-cadinol in Hinoki cypress induces hyaluronic acid production in dermal cells possibly through ERK signaling

Journal of Functional Foods
In Japan, the essential oil from Hinoki cypress (Chamaecyparis obtusa, EOHC) is registered as a flavoring agent for food additives, and previous studies reported it has antibacterial and insect-repellent activities, as well as a relaxation-inducing ...
Takuya Hayakawa, Tatsuki Kagawa, Junko Ando, Shoko Takagi, Miyu Maegawa, Hirotaka Katsuzaki, Takuto Nishimura, Takamasa Ishii, Hiroshi Akiyama, Takehiko Tsuji, Kazuhiro Kagotani, Katsuzumi Okumura   +11 more
doaj   +1 more source

HAS2 wt Allele [PDF]

, 2020
openaire   +1 more source