Results 91 to 100 of about 6,032 (200)
Cardiology Research and PracticePurpose. This study aimed to investigate the impacts of tanshinone IIA (Tan IIA) on ischemia/reperfusion (I/R)-induced cardiomyocyte injury in coronary heart disease (CHD), and to determine whether Tan IIA regulates myocardial cell injury induced by I/R ...
Yanzhe Wang +7 more
doaj +1 more source
Indian Journal of Pathology and MicrobiologyBackground/Aims: In our study, the effect of hyaluronan synthase 2 (HAS2) and CD44 immunoreactivity as a predictive biomarker in the prediction of progesterone-resistant endometrial hyperplasia (EH) cases without atypia was investigated.
Emine Boybay +4 more
doaj +1 more source
, 2021 Die vorliegende Arbeit befasst sich dem Glykosaminoglykan (GAG) Hyaluronan (HA) und dessen Einfluss auf die Entwicklung des malignen Melanoms (MM).
Nguyen, Khiet Tam Christoph
core
A novel ZEB1/HAS2 positive feedback loop promotes EMT in breast cancer
Oncotarget, 2017 Cancer metastasis is the main reason for poor patient survival. Tumor cells delaminate from the primary tumor by induction of epithelial-mesenchymal transition (EMT). EMT is mediated by key transcription factors, including ZEB1, activated by tumor cell interactions with stromal cells and the extracellular matrix (ECM). ZEB1-mediated EMT and motility is
Preca, Bogdan-Tiberius +11 more
openaire +6 more sources
Stab2 and Has2 combinatorial knockdown results in a synergistic inhibitory effect on ISV formation.
, 2014 (A–C) A subphenotypic 1.25 ng dose of Stab2 (B) and 8 ng dose of Has2 (C) morpholinos do not affect vascular development when injected alone. (D) In contrast, Stab2 and Has2 MO co-injection results in 51 percent of embryos that lack ISVs suggesting that ...
Megan S. Rost (528811) +1 more
core +1 more source
MicroRNA-376b is involved in the pathogenesis and remission of Graves' disease by regulating HAS2
, 2022 Abstract Background: Accumulating data suggest that microRNAs play important roles in the pathophysiology of Graves’ disease (GD). The aim of this study was to investigate the changes in the expression of miR-376b and its downstream target, hyaluronan synthase 2 (HAS2), in patients with GD, and the molecular mechanisms involved in the ...
Rongjiao Liu +8 more
openaire +1 more source
Increased HA/CD44/TGFβ signaling implicates in renal fibrosis of a Col4a5 mutant Alport mice
Molecular MedicineX-linked Alport syndrome (XLAS) caused by X-linked COL4A5 gene mutation is a hereditary disease that affects mainly the kidney. XLAS patients, especially males whose single copy of the COL4A5 gene is disrupted, suffer from a life-threatening renal ...
Yantao Bao +8 more
doaj +1 more source
A PRELIMINARY INVESTIGATION INTO THE EXTENDED LIFESPAN OF BAT SPECIES: THE RELATIONSHIP BETWEEN THE EXTRACELLULAR MATRIX PROTEIN HAS2 AND LONGEVITY [PDF]
, 2015 Investigation into physiological and molecular factors influencing the extended lifespan of long-lived species significantly contributes to clinical research aimed at improving the lives of humans.
Denham, Aimee N.
core
rhPRG4 and TGFβ have opposing effects on the protein abundance of CD44 and HAS2.
, 2019 (A) CD44 and phospho-Smad2 (pSmad2) immunoblots of lysates of MDA-MB-231 cells incubated in complete growth medium without (control) or with 100 pM TGFβ, alone or together with 10 μM KI or 100 μg/mL rhPRG4. Actin was used as loading control.
Gregory D. Jay (497394) +8 more
core +1 more source
Reproductive Biology and Endocrinology, 2018 Background In an article published in 2017, we discussed the results of the first part of our study into the morphokinetic development of embryos in relation to follicle diameter and homogeneity of follicular development. Our findings showed that embryos
Semra Kahraman +5 more
doaj +1 more source