Results 101 to 110 of about 6,032 (200)

Melanoma cell-derived factors stimulate hyaluronan synthesis in dermal fibroblasts by upregulating HAS2 through PDGFR-PI3K-AKT and p38 signaling

, 2012
In many cancers hyaluronan content is increased, either by tumor cells or the surrounding stromal cells and this increased hyaluronan content correlates with unfavorable clinical prognosis.
Rauhala, L., Tammi, R., Pasonen-Seppänen, S., Takabe, P., Tammi, M., Edward, M., Rilla, K.   +6 more
core   +1 more source

Has2 is required upstream of Rac1 to govern dorsal migration of lateral cells during zebrafish gastrulation.

, 2004
The large extracellular polysaccharide Hyaluronan (HA) and its synthesizing enzymes (Has) have been implicated in regulating the migratory potential of metastatic cancer cells. Here, we analyze the roles of zebrafish Has2 in normal development. Antisense
Quaedvlieg, N.E.M., Spaink, H., Kramer, C., Bakkers, J., Quaedvlieg, N., Pothof, J., Spaink, H.P., Quaedvlieg, N.E., Hammerschmidt, M.   +8 more
core   +1 more source

Mechanisms of Has2 Regulation and Hyaluronan Signaling During Embryonic Development

, 2010
The cardiovasculature is the first functional system in the developing embryo and as such, it plays a crucial role in the proper nourishment and formation of all other body regions and organs. A detailed understanding the mechanisms that regulate cardiac
Craig, Evisabel Arauz
core  

Kaplan-Meier survival curves of patients according to the expression patterns of HA, HAS2, and

, 2013
HYAL1. Strong expressions of HA (P=0.008) and HAS2 (p=0.022) and weak expression of HYAL1 (p=0.001) were significantly associated with poor survival.
Koji Yamaguchi (93289), Norihiro Sato (243902), Xiao-Bo Cheng (482687), Shiro Kohi (482688)   +3 more
core   +1 more source

Dual inhibition of FAS and HAS2/3 by 4-MU in Realgar-Coptis chinensis unveils a metabolic checkpoint for liver cancer therapy

Natural Products and Bioprospecting
Modern pharmacology has found that both Realgar and Coptis chinensis can induce apoptosis in tumor cells, and traditional Chinese medicine theory suggests the possibility of combining the two, however, the specific mechanisms involved have not been ...
Songtao Wu, Yingying Wang, Denghui Deng, Guohua Zheng, Hanxiang Mei, Cong Wang, Xiang Zheng, Chun Gui, Fei Liao, Meixian Xiang   +9 more
doaj   +1 more source

Differential Regulation of Hyaluronan Synthesis by Three Isoforms of Hyaluronan Synthases in Mammalian Cells

Biomolecules
Hyaluronan (HA) is one of the crucial components of the extracellular matrix in vertebrates and is synthesized by three hyaluronan synthases (HASs), namely HAS1, HAS2, and HAS3.
Jie Wang, Zhikun Wu, Longtao Cao, Feng Long   +3 more
doaj   +1 more source

Correlation of HAS2-associated gene duplications with biological aggressiveness of mast cell tumors in Chinese Shar-Pei dogs [PDF]

, 2013
2013 Fall.Includes bibliographical references.Cutaneous mucinosis in Shar-Pei dogs is the result of excessive dermal hyaluronan, a protein associated with angiogenesis and tumor cell motility in multiple human and canine neoplasms. Cutaneous mucinosis in
Garner, Alana Pavuk, author, Thamm, Douglas, committee member, Basaraba, Randall, committee member, Avery, Anne, advisor   +3 more
core  

Bone quality relies on hyaluronan synthesis – Insights from mice with complete knockout of hyaluronan synthase expression

Matrix Biology Plus
Bone consists of a complex mineralised matrix that is maintained by a controlled equilibrium of synthesis and resorption by different cell types. Hyaluronan (HA) is an important glycosaminoglycan in many tissues including bone.Previously, the importance ...
A. Saalbach, M. Stein, S. Lee, U. Krügel, M. Haffner-Luntzer, K. Krohn, S. Franz, J.C. Simon, J. Tuckermann, U. Anderegg   +9 more
doaj   +1 more source

Prospective validation of the AUB-HAS2 cardiovascular risk index

European Heart Journal - Quality of Care and Clinical Outcomes, 2020
Habib A Dakik, Mahmoud Eldirani, Chris Kaspar, Omar Chehab, Ahmad Msheik, Maha Makki, Hani Tamim   +6 more
openaire   +2 more sources

Abstract P6-08-06: A positive feedback loop couples CD44s and HAS2 for sustained Akt activation and tumor cell survival

, 2017
Breast cancer is the second leading cause of cancer death in women worldwide. Despite recent advances in breast cancer treatment, tumor metastasis and recurrence remain the most significant clinical obstacles, largely due to the resistance of residual ...
C Cheng, S Liu
core   +1 more source