Journal of Biological Chemistry, 2011 Aberrant expression of the human hyaluronan synthase 2 (HAS2) gene has been implicated in the pathology of malignancy, pulmonary arterial hypertension, osteoarthritis, asthma, thyroid dysfunction, and large organ fibrosis.
Daryn R Michael +2 more
exaly +2 more sources
Hyaluronic acid−CD44 signaling from decidual stromal cells orchestrates dNK1 differentiation and immune tolerance in early pregnancy [PDF]
Frontiers in ImmunologyIntroductionSpontaneous abortion (SA) is closely associated with immune homeostasis of decidual natural killer (dNK) cells at the maternal-fetal interface, yet how decidual stromal cells (DSCs) educate NK cells remains incompletely understood.
Di Wang +13 more
doaj +2 more sources
Small extracellular vesicles derived from hair follicle neural crest stem cells enhance perineurial cell proliferation and migration via the TGF-β/SMAD/HAS2 pathway [PDF]
Neural Regeneration ResearchPeripheral nerve defect repair is a complex process that involves multiple cell types; perineurial cells play a pivotal role. Hair follicle neural crest stem cells promote perineurial cell proliferation and migration via paracrine signaling; however ...
Yiming Huo +10 more
doaj +2 more sources
Nephronectin regulates atrioventricular canal differentiation via Bmp4-Has2 signaling in zebrafish [PDF]
Development, 2011 The extracellular matrix is crucial for organogenesis. It is a complex and dynamic component that regulates cell behavior by modulating the activity, bioavailability and presentation of growth factors to cell surface receptors.
Novoyatleva, Tatyana +17 more
core +4 more sources
Journal of Cancer Research and Clinical Oncology, 2022 Purpose Hyaluronan modulates tumour progression, including cell adhesion, cohesion, proliferation and invasion, and the cancer stem cell phenotype. In ovarian cancer, high levels of stromal hyaluronan are associated with poor prognosis.
Jette Riecks +6 more
doaj +2 more sources
Autophagic degradation of HAS2 in endothelial cells: A novel mechanism to regulate angiogenesis
Matrix Biology, 2020 Matrix Biology, 90, 1-19Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.Hyaluronan
Chen, Carolyn G. +6 more
core +3 more sources
Efficient TGFβ-induced epithelial–mesenchymal transition depends on hyaluronan synthase HAS2 [PDF]
Oncogene, 2013 Epithelial-mesenchymal transition (EMT) is a developmental program, which can be adopted by cancer cells to increase their migration and ability to form metastases. Transforming growth factor β (TGFβ) is a well-studied inducer of EMT. We demonstrate that
B Bernert +11 more
core +4 more sources
Cross-disease biomarker identification reveals shared diagnostic biomarkers for IVDD and NAFLD via bulk and single-cell RNA sequencing [PDF]
Frontiers in Molecular NeuroscienceIntroductionIntervertebral disc degeneration (IVDD) and non-alcoholic fatty liver disease (NAFLD) represent major global health burdens. Although recent evidence points to a potential association between these two conditions, the underlying molecular ...
Jiasen Wei +9 more
doaj +2 more sources
Spatially restricted hyaluronan production by Has2 drives epithelial tubulogenesis in vitro
American Journal of Physiology-Cell Physiology, 2014 Generation of branched tubes from an epithelial bud is a fundamental process in development. We hypothesized that induction of hyaluronan synthase (Has) and production of hyaluronan (HA) drives tubulogenesis in response to morphogenetic cytokines ...
Feraille, Eric +4 more
core +4 more sources
The Journal of Clinical InvestigationSteatotic liver enhances liver metastasis of colorectal cancer (CRC), but this process is not fully understood. Steatotic liver induced by a high-fat diet increases cancer-associated fibroblast (CAF) infiltration and collagen and hyaluronic acid (HA ...
Yoon Mee Yang +22 more
doaj +2 more sources