Hyaluronan nanoscale clustering and Hyaluronan synthase 2 expression are linked to the invasion of child fibroblasts and infantile fibrosarcoma in vitro and in vivo [PDF]
Scientific Reports, 2022 Infantile fibrosarcoma is a rare childhood tumour that originates in the fibrous connective tissue of the long bones for which there is an urgent need to identify novel therapeutic targets.
Joseph J. Tonge +7 more
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Heterologous production of hyaluronic acid in Nicotiana tabacum hairy roots expressing a human hyaluronan synthase 2 [PDF]
Scientific Reports, 2021 Hyaluronic acid (HA), a unique polysaccharide with excellent Physico-chemical properties, is broadly used in pharmaceutical, biomedical, and cosmetic fields. It is widely present in all vertebrates, certain bacterial strains, and even viruses while it is
Arezoo Nazeri +5 more
doaj +2 more sources
Requirement of Hyaluronan Synthase-2 in Craniofacial and Palate Development. [PDF]
J Dent Res, 2019 Cleft palate is a common major birth defect resulting from disruption of palatal shelf growth, elevation, or fusion during fetal palatogenesis. Whereas the molecular mechanism controlling palatal shelf elevation is not well understood, a prevailing hypothesis is that region-specific accumulation of hyaluronan, a predominant ...
Lan Y, Qin C, Jiang R.
europepmc +4 more sources
Genetic Deficiency of Hyaluronan Synthase 2 in the Developing Limb Mesenchyme Impairs Postnatal Synovial Joint Formation [PDF]
BiomedicinesHyaluronan, a key component of the extracellular matrix, plays a crucial role in joint development and maintenance. In order to determine the role of hyaluronan function in joint development and homeostasis, conditional loss-of-function experiments of ...
Yingcui Li +10 more
doaj +2 more sources
Hyaluronan synthase 2-mediated hyaluronan production mediates Notch1 activation and liver fibrosis. [PDF]
Sci Transl Med, 2019 Hepatic stellate cells activated by hyaluronan synthase 2–mediated hyaluronan and Notch1 promote liver fibrosis, identifying a potential target.
Yang YM +19 more
europepmc +8 more sources
Hyaluronan synthase 2 expressed by cancer-associated fibroblasts promotes oral cancer invasion [PDF]
Journal of Experimental & Clinical Cancer Research, 2016 Background Hyaluronan synthases (HAS) control the biosynthesis of hyaluronan (HA) and critically modulate the tumor microenviroment. Cancer-associated fibroblasts (CAFs) affect the progression of a tumor by remolding the matrix.
Ziwen Zhang +8 more
doaj +2 more sources
Elevated expression of hyaluronan synthase 2 associates with decreased survival in diffusely infiltrating astrocytomas [PDF]
BMC Cancer, 2018 Background Diffusely infiltrating astrocytomas originate from astrocytic glial cells or their precursor cells and are the most common type of brain tumors in adults. In this retrospective study, we investigated the content of hyaluronan, its cell surface
Mari Valkonen +5 more
doaj +2 more sources
Hyaluronan synthase 2 (HAS2) overexpression diminishes the procatabolic activity of chondrocytes by a mechanism independent of extracellular hyaluronan. [PDF]
J Biol Chem, 2019 Osteoarthritis (OA) is a progressive degenerative disease of the joints caused in part by a change in the phenotype of resident chondrocytes within affected joints. This altered phenotype, often termed proinflammatory or procatabolic, features enhanced production of endoproteinases and matrix metallo-proteinases (MMPs) as well as secretion of ...
Ishizuka S +7 more
europepmc +4 more sources
Hyaluronan synthase 2 regulates fibroblast senescence in pulmonary fibrosis. [PDF]
Matrix Biol, 2016 Dysregulated repair of lung injury often results in lung fibrosis characterized by unremitting deposition of matrix components including glycosaminoglycan hyaluronan (HA). HA is mainly produced by hyaluronan synthases (HAS) in mesenchymal cells.
Li Y +9 more
europepmc +3 more sources
Attenuated Replication-Competent Herpes Simplex Virus Expressing an ECM-Modifying Transgene Hyaluronan Synthase 2 of Naked Mole Rat in Oncolytic Gene Therapy [PDF]
Microorganisms, 2023 Herpes simplex virus (HSV) has proven successful in treating human cancer. Since the approval of talimogene laherparepvec (T-VEC) in 2015, HSV has been thoroughly researched to discover novel mechanisms to combat cancer and treat other diseases.
Jussi Palomäki +7 more
doaj +2 more sources