Results 1 to 10 of about 10,590 (199)

Hyaluronan nanoscale clustering and Hyaluronan synthase 2 expression are linked to the invasion of child fibroblasts and infantile fibrosarcoma in vitro and in vivo [PDF]

Scientific Reports, 2022
Infantile fibrosarcoma is a rare childhood tumour that originates in the fibrous connective tissue of the long bones for which there is an urgent need to identify novel therapeutic targets.
Joseph J. Tonge, Scott V. Notley, Mark J. Dunning, Ana López-Guajardo, Jessica D. Medcalf, Paraskevi Heldin, George Panoutsos, Annica K. B. Gad   +7 more
doaj   +9 more sources

Genetic Deficiency of Hyaluronan Synthase 2 in the Developing Limb Mesenchyme Impairs Postnatal Synovial Joint Formation [PDF]

Biomedicines
Hyaluronan, a key component of the extracellular matrix, plays a crucial role in joint development and maintenance. In order to determine the role of hyaluronan function in joint development and homeostasis, conditional loss-of-function experiments of ...
Yingcui Li, Alexander Tress, Peter Maye, Kemar Edwards, Asiona Findletar, Nathaniel A. Dyment, Yu Yamaguchi, David W. Rowe, Gengyun Le-Chan, Sunny S. K. Chan, Kevin W.-H. Lo   +10 more
doaj   +3 more sources

Hyaluronan synthase 2-mediated hyaluronan production mediates Notch1 activation and liver fibrosis. [PDF]

Sci Transl Med, 2019
Hyaluronan (HA), a major extracellular matrix glycosaminoglycan, is a biomarker for cirrhosis. However, little is known about the regulatory and downstream mechanisms of HA overproduction in liver fibrosis.
Yang YM, Noureddin M, Liu C, Ohashi K, Kim SY, Ramnath D, Powell EE, Sweet MJ, Roh YS, Hsin IF, Deng N, Liu Z, Liang J, Mena E, Shouhed D, Schwabe RF, Jiang D, Lu SC, Noble PW, Seki E.   +19 more
europepmc   +9 more sources

Hyaluronan synthase 2 expressed by cancer-associated fibroblasts promotes oral cancer invasion [PDF]

Journal of Experimental & Clinical Cancer Research, 2016
Background Hyaluronan synthases (HAS) control the biosynthesis of hyaluronan (HA) and critically modulate the tumor microenviroment. Cancer-associated fibroblasts (CAFs) affect the progression of a tumor by remolding the matrix.
Ziwen Zhang, Detao Tao, Ping Zhang, Xue Liu, Yuchao Zhang, Jie Cheng, Hua Yuan, Laikui Liu, Hongbing Jiang   +8 more
doaj   +3 more sources

Heterologous production of hyaluronic acid in Nicotiana tabacum hairy roots expressing a human hyaluronan synthase 2 [PDF]

Scientific Reports, 2021
Hyaluronic acid (HA), a unique polysaccharide with excellent Physico-chemical properties, is broadly used in pharmaceutical, biomedical, and cosmetic fields. It is widely present in all vertebrates, certain bacterial strains, and even viruses while it is
Arezoo Nazeri, Ali Niazi, Alireza Afsharifar, Seyed Mohsen Taghavi, Ali Moghadam, Farzaneh Aram   +5 more
doaj   +2 more sources

Elevated expression of hyaluronan synthase 2 associates with decreased survival in diffusely infiltrating astrocytomas [PDF]

BMC Cancer, 2018
Background Diffusely infiltrating astrocytomas originate from astrocytic glial cells or their precursor cells and are the most common type of brain tumors in adults. In this retrospective study, we investigated the content of hyaluronan, its cell surface
Mari Valkonen, Hannu Haapasalo, Kirsi Rilla, Kristiina Tyynelä-Korhonen, Ylermi Soini, Sanna Pasonen-Seppänen   +5 more
doaj   +2 more sources

Attenuated Replication-Competent Herpes Simplex Virus Expressing an ECM-Modifying Transgene Hyaluronan Synthase 2 of Naked Mole Rat in Oncolytic Gene Therapy [PDF]

Microorganisms, 2023
Herpes simplex virus (HSV) has proven successful in treating human cancer. Since the approval of talimogene laherparepvec (T-VEC) in 2015, HSV has been thoroughly researched to discover novel mechanisms to combat cancer and treat other diseases.
Jussi Palomäki, Kiira Kalke, Julius Orpana, Liisa Lund, Fanny Frejborg, Henrik Paavilainen, Hannu Järveläinen, Veijo Hukkanen   +7 more
doaj   +2 more sources

Coding Sequence of a Hyaluronan Synthase Homologue Expressed during Expansion of the Mouse Cumulus–Oocyte Complex

Archives of Biochemistry and Biophysics, 1997
Maturation of mammalian cumulus cell-oocyte complex in the preovulatory follicle involves the deposition of a hyaluronan-rich extracellular matrix by the cumulus cells.
Csaba Fülöp, Antonietta Salustri, Vincent C Hascall   +2 more
exaly   +2 more sources

A novel mutation of Hyaluronan synthase 2 gene in Chinese children with ventricular septal defect. [PDF]

PLoS ONE, 2014
As a major product of extracellular matrix (ECM), Hyaluronic acid (HA) is involved in early cardiac development and mainly synthesized by Hyaluronan synthase 2 (HAS2) during embryogenesis. Targeted deletion of HAS2 gene in mice led to obvious cardiac and
Xiaomei Zhu, Xiaopeng Deng, Guangying Huang, Jing Wang, Jingwen Yang, Si Chen, Xu Ma, Binbin Wang   +7 more
doaj   +2 more sources

Knockdown of Hyaluronan synthase 2 suppresses liver fibrosis in mice via induction of transcriptomic changes similar to 4MU treatment [PDF]

Scientific Reports
Hepatic fibrosis remains a significant clinical challenge due to ineffective treatments. 4-methylumbelliferone (4MU), a hyaluronic acid (HA) synthesis inhibitor, has proven safe in phase one clinical trials.
Noreen Halimani, Mikhail Nesterchuk, Alexandra A. Tsitrina, Marat Sabirov, Irina N. Andreichenko, Nataliya O. Dashenkova, Elizaveta Petrova, Alexey M. Kulikov, Timofei S. Zatsepin, Roman A. Romanov, Arsen S. Mikaelyan, Yuri V. Kotelevtsev   +11 more
doaj   +2 more sources