Results 21 to 30 of about 10,107 (167)
Nanotherapy in Joints: Increasing Endogenous Hyaluronan Production by Delivering Hyaluronan Synthase 2 [PDF]
Advanced Materials, 2019 AbstractOsteoarthritis (OA) is a common joint degenerative disease that causes pain, joint damage, and dysfunction. External hyaluronic acid (HA) supplement is a common method for the management of osteoarthritis which requires multi‐injections. It is demonstrated that biodegradable mesoporous silica nanoparticles successfully deliver an enzyme ...
Huimin Li +11 more
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Salicylate suppresses the oncogenic hyaluronan network in metastatic breast cancer cells
Matrix Biology Plus, 2020 The oncogenic role of hyaluronan in several aspects of tumor biology has been well established. Recent studies by us and others suggest that inhibition of hyaluronan synthesis could represent an emerging therapeutic approach with significant clinical ...
Theodoros T. Karalis +6 more
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Reproductive Biology and Endocrinology, 2022 Background Hyaluronan is the main component of the cumulus-oocyte complex (COC) matrix, and it maintains the basic structure of the COC during ovulation.
Hsun-Ming Chang +3 more
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Cell Adhesion & Migration, 2023 The sensitivity to cold plasma is specific to tumor cells while leaving normal tissue cells unaffected. This is the desired challenge in cancer therapy. Therefore, the focus of this work was a comparative study concerning the plasma sensitivity of dermal
Anna-Christin Golz +5 more
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Natural Antisense mRNAs to Hyaluronan Synthase 2 Inhibit Hyaluronan Biosynthesis and Cell Proliferation [PDF]
Journal of Biological Chemistry, 2005 We report the identification of a natural antisense mRNA of hyaluronan synthase 2 that we have chosen to designate as HASNT (for HA synthase 2 antisense) in human and mouse. HASNT is transcribed from the opposite strand of the HAS2 gene locus and is represented by several independent expressed sequence tags in human.
Hsu, Chao, Andrew P, Spicer
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Scientific Reports, 2021 Moyamoya disease (MMD) is characterized by progressive bilateral stenotic changes in the terminal portion of the internal carotid arteries. Although RNF213 was identified as a susceptibility gene for MMD, the exact pathogenesis remains unknown ...
Muneaki Matsuo +11 more
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Matrix Biology Plus, 2021 In the extracellular matrix (ECM), the glycosaminoglycan (GAG) hyaluronan (HA) has different physiological roles favouring hydration, elasticity and cell survival.
Arianna Parnigoni +6 more
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Overexpression of Hyaluronan Synthase 2 Alters Hyaluronan Distribution and Function in Proximal Tubular Epithelial Cells [PDF]
Journal of the American Society of Nephrology, 2006 The functional consequences of increased renal cortical hyaluronan that is associated with both acute injury and progressive scarring are unclear. The aim of this study was to characterize hyaluronan synthase-2 (HAS2)-driven HA synthesis and determine its effect on renal proximal tubular epithelial cell (PTC) function, because this is known to be the ...
Selbi, Wisam +7 more
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HAS2-Ezrin-ER axis plays a role in acquired antiestrogen resistance of ER-positive breast cancer
Frontiers in Pharmacology, 2022 The development of endocrine resistance is a major clinical problem in estrogen receptor-positive (ER+) breast cancer (BrCa) treatment, in which how cancer cells acquire resistance remains obscure.
Xiaodan Sun +12 more
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HAS2 (hyaluronan synthase 2) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011 Review on HAS2 (hyaluronan synthase 2), with data on DNA, on the protein encoded, and where the gene is implicated.
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