Results 11 to 20 of about 10,590 (199)

Nanotherapy in joints: increasing endogenous hyaluronan production by delivering hyaluronan synthase 2 [PDF]

Advanced Materials, 2019
Osteoarthritis (OA) is a common joint degenerative disease that causes pain, joint damage, and dysfunction. External hyaluronic acid (HA) supplement is a common method for the management of osteoarthritis which requires multi-injections.
Yu, Chengzhong, Liu, Li, Song, Hao, Long, Xing, Xu, Liqin, Lei, Chang, Fang, Wei, Xu, Chun, Ke, Jin, Feng, Yaping, Li, Huimin, Guo, Huilin   +11 more
core   +6 more sources

Cancer-Associated Fibroblasts Move and Interact More with Triple-Negative Breast Cancer Cells and Stimulate Their Proliferation in a Hyaluronan-Dependent Manner [PDF]

Cells
While normal fibroblasts suppress tumor growth, during cancer initiation and progression, this capacity can be lost and even switched to tumor-promoting, for reasons that are not understood.
Sz-Ying Hou, Sarah C. Macfarlane, Ariadna Gómez Torijano, Hyejeong Rosemary Kim, Marieke Rosier, Katalin Dobra, Penelope D. Ottewell, Annica K. B. Gad   +7 more
doaj   +2 more sources

Interleukin-1 Beta Mediated Regulation of Hyaluronan and Hyaluronan Synthase 2

, 2005
Elevated levels of hyaluronan are associated with numerous inflammatory diseases including ulcerative colitis, Crohn\u27s disease and wound healing. Various proinflammatory cytokines have shown to influence hyaluronan expression in cells originating ...
Ducale, Ashley Elizabeth
core   +2 more sources

Transcriptional regulation of the human hyaluronan synthase genes: focus on hyaluronan synthase 2 [PDF]

This thesis examines the transcriptional regulation of the human hyaluronan synthase (HAS) genes, with particular focus on hyaluronan synthase 2. The data details the reconstruction of the genomic structures of each HAS isoform for the first time, as ...
Monslow, Jamie
core   +1 more source

Molecular evolution of the hyaluronan synthase 2 gene in mammals: implications for adaptations to the subterranean niche and cancer resistance. [PDF]

Biol Lett, 2015
The naked mole-rat (NMR) Heterocephalus glaber is a unique and fascinating mammal exhibiting many unusual adaptations to a subterranean lifestyle.
Faulkes CG, Davies KT, Rossiter SJ, Bennett NC.   +3 more
europepmc   +2 more sources

Overexpression of hyaluronan synthase 2 alters hyaluronan distribution and function in proximal tubular epithelial cells [PDF]

Journal of the American Society of Nephrology, 2006
The functional consequences of increased renal cortical hyaluronan that is associated with both acute injury and progressive scarring are unclear. The aim of this study was to characterize hyaluronan synthase-2 (HAS2)-driven HA synthesis and determine ...
Csaba Fülöp, Fülöp, Csaba, Wisam Selbi, Carol A. de la Motte, Bowen, Timothy, Vincent C. Hascall, Aled O. Phillips, Rugg, Marilyn S., Timothy Bowen, Day, Anthony J.; id_orcid, Marilyn S. Rugg, De La Motte, Carol A., Phillips, Aled O., Hascall, Vincent C., Selbi, Wisam, Anthony J. Day   +15 more
core   +3 more sources

Insights into substrate binding and utilization by hyaluronan synthase [PDF]

eLife
Hyaluronan (HA), a heteropolysaccharide of alternating N-acetylglucosamine (GlcNAc) and glucuronic acid (GlcA), is an essential component of the vertebrate extracellular matrix.
Zachery Stephens, Julia Karasinska, Jochen Zimmer   +2 more
doaj   +2 more sources

Disruption of hyaluronan synthase-2 abrogates normal cardiac morphogenesis and hyaluronan-mediated transformation of epithelium to mesenchyme [PDF]

Journal of Clinical Investigation, 2000
We identified hyaluronan synthase-2 (Has2) as a likely source of hyaluronan (HA) during embryonic development, and we used gene targeting to study its function in vivo. Has2-/- embryos lack HA, exhibit severe cardiac and vascular abnormalities, and die
Tammy Brehm-Gibson, Klewer, Scott E., Calabro, Anthony, Jr., Scott E. Klewer, Spicer, Andrew P., Brehm-Gibson, Tammy, Augustine, Mary Lou, Kubalak, Steven, Jennifer Biesterfeldt, Jennifer, Andrew P. Spicer, Anthony Calabro, Todd D. Camenisch, Steven Kubalak, Mary Lou Augustine, Jennifer Biesterfeldt, Camenisch, Todd D., John A. McDonald   +16 more
core   +3 more sources

Expression of hyaluronan synthase 2 or hyaluronidase 1 differentially affect the growth rate of transplantable colon carcinoma cell tumors

International Journal of Cancer, 2002
Advanced colorectal cancers are often associated with elevated amounts of hyaluronan. To investigate the importance of hyaluronan in colon carcinoma tumor progression, we have expressed by stable transfection hyaluronan synthase 2 (Has2) and ...
Kristofer Rubin, Paraskevi Heldin
exaly   +3 more sources

Epidermal growth factor activates hyaluronan synthase 2 in epidermal keratinocytes and increases pericellular and intracellular hyaluronan [PDF]

Journal of Biological Chemistry, 2001
Hyaluronan is an abundant and rapidly turned over matrix molecule between the vital cell layers of the epidermis. In this study, epidermal growth factor (EGF) induced a coat of hyaluronan and a 3-5-fold increase in its rate of synthesis in a rat ...
Sironen, Reijo,, Tammi, Markku,, Fulop, Csaba,, Karvinen, Susanna,, Lammi, Mikko,, Pienimaki, Juha-Pekka,, Pasonen, Sanna,, Hascall, Vince,, Rilla, Kirsi,, Tammi, Raija,   +9 more
core   +3 more sources