Results 11 to 20 of about 10,107 (167)

Antisense inhibition of hyaluronan synthase-2 in human osteosarcoma cells inhibits hyaluronan retention and tumorigenicity [PDF]

Experimental Cell Research, 2005
Osteosarcoma is a common malignant bone tumor associated with childhood and adolescence. The results of numerous studies have suggested that hyaluronan plays an important role in regulating the aggressive behavior of various types of cancer cells. However, no studies have addressed hyaluronan with respect to osteosarcomas.
Yoshihiro Nishida, Warren Knudson, Ishiguro Naoki   +2 more
exaly   +3 more sources

Human Keratinocytes Respond to Extracellular UTP by Induction of Hyaluronan Synthase 2 Expression and Increased Hyaluronan Synthesis. [PDF]

J Biol Chem, 2017
The release of nucleotides into extracellular space is triggered by insults like wounding and ultraviolet radiation, resulting in stimulatory or inhibitory signals via plasma membrane nucleotide receptors. As similar insults are known to activate hyaluronan synthesis we explored the possibility that extracellular UTP or its breakdown products UDP and ...
Jokela T, Kärnä R, Rauhala L, Bart G, Pasonen-Seppänen S, Oikari S, Tammi MI, Tammi RH.   +7 more
europepmc   +4 more sources

TGF-β1 upregulates the expression of hyaluronan synthase 2 and hyaluronan synthesis in culture models of equine articular chondrocytes. [PDF]

J Vet Sci, 2018
We investigated the effect of transforming growth factor beta 1 (TGF-β1) on equine hyaluronan synthase 2 (HAS2) gene expression and hyaluronan (HA) synthesis in culture models of articular chondrocytes. Equine chondrocytes were treated with TGF-β1 at different concentrations and times in monolayer cultures.
Ongchai S, Somnoo O, Kongdang P, Peansukmanee S, Tangyuenyong S.   +4 more
europepmc   +3 more sources

The activity of hyaluronan synthase 2 is regulated by dimerization and ubiquitination. [PDF]

J Biol Chem, 2010
Hyaluronan is a component of the extracellular matrix, which affects tissue homeostasis. In this study, we investigated the regulatory mechanisms of one of the hyaluronan-synthesizing enzymes, HAS2. Ectopic expression of Flag- and 6myc-HAS2 in COS-1 cells followed by immunoprecipitation and immunoblotting revealed homodimers; after co-transfection with
Karousou E, Kamiryo M, Skandalis SS, Ruusala A, Asteriou T, Passi A, Yamashita H, Hellman U, Heldin CH, Heldin P.   +9 more
europepmc   +5 more sources

Knockdown of Hyaluronan synthase 2 suppresses liver fibrosis in mice via induction of transcriptomic changes similar to 4MU treatment [PDF]

Scientific Reports
Hepatic fibrosis remains a significant clinical challenge due to ineffective treatments. 4-methylumbelliferone (4MU), a hyaluronic acid (HA) synthesis inhibitor, has proven safe in phase one clinical trials.
Noreen Halimani, Mikhail Nesterchuk, Alexandra A. Tsitrina, Marat Sabirov, Irina N. Andreichenko, Nataliya O. Dashenkova, Elizaveta Petrova, Alexey M. Kulikov, Timofei S. Zatsepin, Roman A. Romanov, Arsen S. Mikaelyan, Yuri V. Kotelevtsev   +11 more
doaj   +2 more sources

A novel mutation of Hyaluronan synthase 2 gene in Chinese children with ventricular septal defect. [PDF]

PLoS ONE, 2014
As a major product of extracellular matrix (ECM), Hyaluronic acid (HA) is involved in early cardiac development and mainly synthesized by Hyaluronan synthase 2 (HAS2) during embryogenesis. Targeted deletion of HAS2 gene in mice led to obvious cardiac and
Xiaomei Zhu, Xiaopeng Deng, Guangying Huang, Jing Wang, Jingwen Yang, Si Chen, Xu Ma, Binbin Wang   +7 more
doaj   +2 more sources

Cancer-Associated Fibroblasts Move and Interact More with Triple-Negative Breast Cancer Cells and Stimulate Their Proliferation in a Hyaluronan-Dependent Manner [PDF]

Cells
While normal fibroblasts suppress tumor growth, during cancer initiation and progression, this capacity can be lost and even switched to tumor-promoting, for reasons that are not understood.
Sz-Ying Hou, Sarah C. Macfarlane, Ariadna Gómez Torijano, Hyejeong Rosemary Kim, Marieke Rosier, Katalin Dobra, Penelope D. Ottewell, Annica K. B. Gad   +7 more
doaj   +2 more sources

Insights into substrate binding and utilization by hyaluronan synthase [PDF]

eLife
Hyaluronan (HA), a heteropolysaccharide of alternating N-acetylglucosamine (GlcNAc) and glucuronic acid (GlcA), is an essential component of the vertebrate extracellular matrix.
Zachery Stephens, Julia Karasinska, Jochen Zimmer   +2 more
doaj   +2 more sources

Synaptic Hyaluronan Synthesis and CD44-Mediated Signaling Coordinate Neural Circuit Development

Cells, 2021
The hyaluronan-based extracellular matrix is expressed throughout nervous system development and is well-known for the formation of perineuronal nets around inhibitory interneurons.
Emily S. Wilson, Karen Litwa
doaj   +1 more source

SARS-CoV-2 RNA elements share human sequence identity and upregulate hyaluronan via NamiRNA-enhancer network

EBioMedicine, 2022
Summary: Background: Since late 2019, SARS-CoV-2 infection has resulted in COVID-19 accompanied by diverse clinical manifestations. However, the underlying mechanism of how SARS-CoV-2 interacts with host and develops multiple symptoms is largely ...
Wei Li, Shuai Yang, Peng Xu, Dapeng Zhang, Ying Tong, Lu Chen, Ben Jia, Ang Li, Cheng Lian, Daoping Ru, Baolong Zhang, Mengxing Liu, Cancan Chen, Weihui Fu, Songhua Yuan, Chenjian Gu, Lu Wang, Wenxuan Li, Ying Liang, Zhicong Yang, Xiaoguang Ren, Shaoxuan Wang, Xiaoyan Zhang, Yuanlin Song, Youhua Xie, Hongzhou Lu, Jianqing Xu, Hailin Wang, Wenqiang Yu   +28 more
doaj   +1 more source