Results 31 to 40 of about 10,107 (167)

Hyaluronan synthases (HAS1-3) and hyaluronidases (HYAL1-2) in the accumulation of hyaluronan in endometrioid endometrial carcinoma [PDF]

BMC Cancer, 2010
Abstract Background Hyaluronan accumulation correlates with the degree of malignancy in many solid tumor types, including malignant endometrial carcinomas. To elucidate the mechanism of hyaluronan accumulation, we examined the expression levels of the hyaluronan synthases (HAS1, HAS2 and HAS3) and hyaluronidases ...
Kosma Veli-Matti, Hämäläinen Kirsi, Sironen Reijo, Tammi Raija H, Rilla Kirsi, Tammi Markku I, Nykopp Timo K, Heinonen Seppo, Anttila Maarit   +8 more
openaire   +3 more sources

Fibroblast and keratinocyte gene expression following exposure to extracts of neem plant (Azadirachta indica)

Data in Brief, 2018
This data article provides gene expression profiles, determined by using real-time PCR, of fibroblasts and keratinocytes treated with 0.01% and 0.001% extracts of neem plant (Azadirachta indica), local name “Kohomba” in Sri Lanka, harvested in Sri Lanka.
Takao Someya, Katsura Sano, Kotaro Hara, Yoshimasa Sagane, Toshihiro Watanabe, R.G.S. Wijesekara   +5 more
doaj   +1 more source

The Malignant Phenotype of Breast Cancer Cells Is Reduced by COX-2 Silencing

Neoplasia: An International Journal for Oncology Research, 2008
The cyclooxygenase (COX) pathway is currently targeted for therapeutic intervention in different cancers. We have previously shown that silencing of COX-2 in the poorly differentiated metastatic breast cell line MDA-MB-231 by RNA interference markedly ...
Ioannis Stasinopoulos, Noriko Mori, Zaver M. Bhujwalla   +2 more
doaj   +1 more source

Has2 Regulates the Development of Ovalbumin-Induced Airway Remodeling and Steroid Insensitivity in Mice

Frontiers in Immunology, 2022
HAS2 is a member of the gene family encoding the hyaluronan synthase 2, which can generate high-molecular-weight hyaluronan (HMW-HA). Our previous study identified HAS2 as a candidate gene for increased susceptibility to adult asthma.
Mingma Thsering Sherpa, Takumi Kiwamoto, Masashi Matsuyama, Yoshiya Tsunoda, Kai Yazaki, Kazufumi Yoshida, Masayuki Nakajima, Yosuke Matsuno, Yuko Morishima, Yukio Ishii, Nobuyuki Hizawa   +10 more
doaj   +1 more source

Disruption of hyaluronan synthase-2 abrogates normal cardiac morphogenesis and hyaluronan-mediated transformation of epithelium to mesenchyme [PDF]

Journal of Clinical Investigation, 2000
We identified hyaluronan synthase-2 (Has2) as a likely source of hyaluronan (HA) during embryonic development, and we used gene targeting to study its function in vivo. Has2(-/-) embryos lack HA, exhibit severe cardiac and vascular abnormalities, and die during midgestation (E9.5-10).
T D, Camenisch, A P, Spicer, T, Brehm-Gibson, J, Biesterfeldt, M L, Augustine, A, Calabro, S, Kubalak, S E, Klewer, J A, McDonald   +8 more
openaire   +2 more sources

Effect of red ginseng NaturalGEL on skin aging

Journal of Ginseng Research, 2020
Background: In aged skin, degradation of collagen fibers, which occupy the majority of the extracellular matrix in the dermis, and changes of aquaporin 3 (AQP3) and skin constituents, such as hyaluronic acid and ceramide, cause wrinkles and decrease skin
Ye Hyang Kim, Hye Rim Park, So Yoon Cha, So Hun Lee, Jung Wung Jo, Jung Nam Go, Kang Hyuk Lee, Su Yeon Lee, Song Seok Shin   +8 more
doaj   +1 more source

Epidermal Growth Factor Activates Hyaluronan Synthase 2 in Epidermal Keratinocytes and Increases Pericellular and Intracellular Hyaluronan [PDF]

Journal of Biological Chemistry, 2001
Hyaluronan is an abundant and rapidly turned over matrix molecule between the vital cell layers of the epidermis. In this study, epidermal growth factor (EGF) induced a coat of hyaluronan and a 3-5-fold increase in its rate of synthesis in a rat epidermal keratinocyte cell line that has retained its ability for differentiation.
J P, Pienimaki, K, Rilla, C, Fulop, R K, Sironen, S, Karvinen, S, Pasonen, M J, Lammi, R, Tammi, V C, Hascall, M I, Tammi   +9 more
openaire   +2 more sources

Fibroblast and keratinocyte gene expression following exposure to the extracts of holy basil plant (Ocimum tenuiflorum), malabar nut plant (Justicia adhatoda), and emblic myrobalan plant (Phyllanthus emblica)

Data in Brief, 2018
This data article provides gene expression profiles, determined by using real-time PCR, of fibroblasts and keratinocytes treated with 0.01% and 0.001% extracts of holy basil plant (Ocimum tenuiflorum), sri lankan local name “maduruthala”, 0.1% and 0.01 ...
Takao Someya, Katsura Sano, Kotaro Hara, Yoshimasa Sagane, Toshihiro Watanabe, R.G.S. Wijesekara   +5 more
doaj   +1 more source

Identification and Analysis of the Promoter Region of the Human Hyaluronan Synthase 2 Gene [PDF]

Journal of Biological Chemistry, 2004
Hyaluronan (HA) is a linear glycosaminoglycan of the vertebrate extracellular matrix that is synthesized at the plasma membrane by the HA synthase (HAS) enzymes HAS1, -2 and -3. The regulation of HA synthesis has been implicated in a variety of extracellular matrix-mediated and pathological processes, including renal fibrosis.
Jamie, Monslow, John D, Williams, Carol A, Guy, Iain K, Price, Kathrine J, Craig, Hywel J, Williams, Nigel M, Williams, John, Martin, Sharon L, Coleman, Nicholas, Topley, Andrew P, Spicer, Paul R, Buckland, Malcolm, Davies, Timothy, Bowen   +13 more
openaire   +2 more sources

The Calcium-Sensing Receptor Is Involved in Follicle-Stimulating Hormone-Induced Cumulus Expansion in in vitro Cultured Porcine Cumulus-Oocyte Complexes

Frontiers in Cell and Developmental Biology, 2021
The Calcium-Sensing Receptor (CASR) is a G protein-coupled receptor of the C family that reportedly promotes maturation of porcine oocytes. However, its role in cumulus expansion of cumulus-oocyte complexes (COCs) is not well known.
Huage Liu, Huage Liu, Dan Zhou, Cong Liu, Qingrui Zhuan, Yan Luo, Xianhong Mo, Xiangwei Fu, Yunpeng Hou   +8 more
doaj   +1 more source