Results 51 to 60 of about 10,107 (167)

Sp1 and Sp3 Mediate Constitutive Transcription of the Human Hyaluronan Synthase 2 Gene [PDF]

Journal of Biological Chemistry, 2006
The linear glycosaminoglycan hyaluronan (HA) is synthesized at the plasma membrane by the HA synthase (HAS) enzymes HAS1, -2, and -3 and performs multiple functions as part of the vertebrate extracellular matrix. Up-regulation of HA synthesis in the renal corticointerstitium, and the resultant extracellular matrix expansion, is a common feature of ...
Jamie, Monslow, John D, Williams, Donald J, Fraser, Daryn R, Michael, Pelagia, Foka, Ann P, Kift-Morgan, Dong Dong, Luo, Ceri A, Fielding, Kathrine J, Craig, Nicholas, Topley, Simon A, Jones, Dipak P, Ramji, Timothy, Bowen   +12 more
openaire   +2 more sources

Oocyte–cumulus cell interaction: a key factor in early embryo development

Biological Reviews, EarlyView.
ABSTRACT The evaluation of oocyte competence is a fundamental step in achieving successful outcomes following assisted reproduction techniques (ART). At present, however, conventional oocyte maturation assessment is carried out by morphological observation, which is a subjective method that does not consider molecular features.
Marc Torres‐Garrido, Marc Yeste, Yentel Mateo‐Otero   +2 more
wiley   +1 more source

Effects of Ferrostatin‐1 on Vocal Folds in Aging Rats

The Laryngoscope, EarlyView.
Age‐related vocal fold degeneration is associated with oxidative stress, and ferroptosis may contribute to structural changes in aging vocal folds. In this aged rat model, intracordal injection of the antioxidant ferrostatin‐1 attenuated ferroptosis‐related changes and was associated with modulation of collagen accumulation, hyaluronic acid ...
Yong‐Il Cheon, Soo‐Young Bang, Ji Min Kim, Ha‐Nee Kwon, Minhyung Lee, Eui‐Suk Sung, Jin‐Choon Lee, Byung‐Joo Lee, Sung‐Chan Shin   +8 more
wiley   +1 more source

Investigation of Hyaluronan Synthase 2 and CD44 immune reactivity as a biomarker to predict Progesterone-Resistant Endometrial Hyperplasia without atypia: A retrospective case-control study

Indian Journal of Pathology and Microbiology
Background/Aims: In our study, the effect of hyaluronan synthase 2 (HAS2) and CD44 immunoreactivity as a predictive biomarker in the prediction of progesterone-resistant endometrial hyperplasia (EH) cases without atypia was investigated.
Emine Boybay, Remzi Atilgan, Şehmus Pala, Tuncay Kuloğlu, Gökhan Artaş   +4 more
doaj   +1 more source

Hyaluronan synthase-2 upregulation protects smpd3-deficient fibroblasts against cell death induced by nutrient deprivation, but not against apoptosis evoked by oxidized LDL

Redox Biology, 2015
The neutral type 2 sphingomyelinase (nSMase2) hydrolyzes sphingomyelin and generates ceramide, a major bioactive sphingolipid mediator, involved in growth arrest and apoptosis.
Sandra Garoby-Salom, Myriam Rouahi, Elodie Mucher, Nathalie Auge, Robert Salvayre, Anne Negre-Salvayre   +5 more
doaj   +1 more source

Dysregulation of Pulmonary Responses in Severe COVID-19

Viruses, 2021
Patients with coronavirus disease 2019 (COVID-19) predominantly have a respiratory tract infection with various symptoms and high mortality is associated with respiratory failure second to severe disease. The risk factors leading to severe disease remain
Dandan Wu, Xuexian O. Yang
doaj   +1 more source

Osteopontin Induction of Hyaluronan Synthase 2 Expression Promotes Breast Cancer Malignancy [PDF]

Journal of Biological Chemistry, 2006
Osteopontin (OPN) is a tumor-associated, secreted phosphoprotein that has been implicated in breast cancer progression and metastasis. Research concerning how OPN functions in tumor progression has led to the identification of a limited number of genes that contribute functionally to OPN-induced cellular behaviors. Recent microarray analysis, comparing
Amy C, Cook, Ann F, Chambers, Eva A, Turley, Alan B, Tuck   +3 more
openaire   +2 more sources

Heparan sulfate and glycomimetics: Advances in synthesis and biological applications for post‐stroke neurorepair

Neuroprotection, EarlyView.
ECM, extracellular matrix; BDNF, brain‐derived neuroptrophic factor; FGF, fibroblast growth factor; VEGF, vascular endothelial growth factor. Abstract Heparan sulfate, a structurally diverse glycosaminoglycan that is abundant in the central nervous system (CNS), orchestrates essential processes fundamental to neural plasticity, neurorepair, and ...
Mozammel H. Bhuiyan, Madeleine J. Smith, Simon F. R. Hinkley, Andrew N. Clarkson   +3 more
wiley   +1 more source

Growth inhibition associated with disruption of the actin cytoskeleton by Latrunculin A in rhabdomyosarcoma cells.

PLoS ONE, 2020
Functional genomic screening of KRAS-driven mouse sarcomas was previously employed to identify proliferation-relevant genes. Genes identified included Ubiquitin-conjugating enzyme E2 (Ube2c), Centromere Protein E (Cenpe), Hyaluronan Synthase 2 (Has2 ...
Julia Würtemberger, Daria Tchessalova, Carla Regina, Christoph Bauer, Michaela Schneider, Amy J Wagers, Simone Hettmer   +6 more
doaj   +2 more sources

Shear stress increases endothelial hyaluronan synthase 2 and hyaluronan synthesis especially in regard to an atheroprotective flow profile. [PDF]

Experimental physiology, 2011
Recent studies revealed that in vivo the inner blood vessel surface is lined with an endothelial surface layer at least 0.5 μm thick, which serves as an aegis, protecting the vessel wall from arteriosclerosis. Hyaluronan seems to be a constitutive component in regard to the atheroprotective properties of this surface structure.
Julian, Maroski, Bernd J, Vorderwülbecke, Katarzyna, Fiedorowicz, Luis, Da Silva-Azevedo, Günter, Siegel, Alex, Marki, Axel Radlach, Pries, Andreas, Zakrzewicz   +7 more
openaire   +3 more sources