Results 41 to 50 of about 10,590 (199)

HAS2-Ezrin-ER axis plays a role in acquired antiestrogen resistance of ER-positive breast cancer

Frontiers in Pharmacology, 2022
The development of endocrine resistance is a major clinical problem in estrogen receptor-positive (ER+) breast cancer (BrCa) treatment, in which how cancer cells acquire resistance remains obscure.
Xiaodan Sun, Xiaodan Sun, Fen Tang, Qian Guo, Yiwen Liu, Yiqing He, Yan Du, Feng Gao, Feng Gao, Guoliang Zhang, Guoliang Zhang, Cuixia Yang, Cuixia Yang   +12 more
doaj   +1 more source

In vitro synthesis of heparosan using recombinant Pasteurella multocida heparosan synthase PmHS2 [PDF]

, 2009
In vertebrates and bacteria, heparosan the precursor of heparin is synthesized by glycosyltransferases via the stepwise addition of UDP-N-acetylglucosamine and UDP-glucuronic acid.
Kooy, F.K., Eggink, G., Springer, J., Chavaroche, A.A.E., Anaïs A. E. Chavaroche, Boeriu, C.G., Floor Kooy, Gerrit Eggink, Jan Springer, Carmen Boeriu   +9 more
core   +1 more source

Requirement of Multiple Signaling Pathways for the Augmented Production of Hyaluronan by V-SRC [PDF]

, 2005
2005-06Malignant transformation of cells is frequently associated with an augmented production of hyaluronan and the subsequent formation of a hyaluronan-matrix.
Huang, Pengyu, Naito, Yuko, Suzuki, Noriko, Hasegawa, Hitoki, Iwamoto, Takashi, Sohara, Yasuyoshi, Hamaguchi, Michinari   +6 more
core   +1 more source

HAS2 (hyaluronan synthase 2) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011
Review on HAS2 (hyaluronan synthase 2), with data on DNA, on the protein encoded, and where the gene is implicated.
openaire   +2 more sources

Hyaluronan synthases (HAS1-3) and hyaluronidases (HYAL1-2) in the accumulation of hyaluronan in endometrioid endometrial carcinoma [PDF]

BMC Cancer, 2010
Abstract Background Hyaluronan accumulation correlates with the degree of malignancy in many solid tumor types, including malignant endometrial carcinomas. To elucidate the mechanism of hyaluronan accumulation, we examined the expression levels of the hyaluronan synthases (HAS1, HAS2 and HAS3) and hyaluronidases ...
Kosma Veli-Matti, Hämäläinen Kirsi, Sironen Reijo, Tammi Raija H, Rilla Kirsi, Tammi Markku I, Nykopp Timo K, Heinonen Seppo, Anttila Maarit   +8 more
openaire   +3 more sources

Fibroblast and keratinocyte gene expression following exposure to extracts of neem plant (Azadirachta indica)

Data in Brief, 2018
This data article provides gene expression profiles, determined by using real-time PCR, of fibroblasts and keratinocytes treated with 0.01% and 0.001% extracts of neem plant (Azadirachta indica), local name “Kohomba” in Sri Lanka, harvested in Sri Lanka.
Takao Someya, Katsura Sano, Kotaro Hara, Yoshimasa Sagane, Toshihiro Watanabe, R.G.S. Wijesekara   +5 more
doaj   +1 more source

Has2 Regulates the Development of Ovalbumin-Induced Airway Remodeling and Steroid Insensitivity in Mice

Frontiers in Immunology, 2022
HAS2 is a member of the gene family encoding the hyaluronan synthase 2, which can generate high-molecular-weight hyaluronan (HMW-HA). Our previous study identified HAS2 as a candidate gene for increased susceptibility to adult asthma.
Mingma Thsering Sherpa, Takumi Kiwamoto, Masashi Matsuyama, Yoshiya Tsunoda, Kai Yazaki, Kazufumi Yoshida, Masayuki Nakajima, Yosuke Matsuno, Yuko Morishima, Yukio Ishii, Nobuyuki Hizawa   +10 more
doaj   +1 more source

The Malignant Phenotype of Breast Cancer Cells Is Reduced by COX-2 Silencing

Neoplasia: An International Journal for Oncology Research, 2008
The cyclooxygenase (COX) pathway is currently targeted for therapeutic intervention in different cancers. We have previously shown that silencing of COX-2 in the poorly differentiated metastatic breast cell line MDA-MB-231 by RNA interference markedly ...
Ioannis Stasinopoulos, Noriko Mori, Zaver M. Bhujwalla   +2 more
doaj   +1 more source

Effect of red ginseng NaturalGEL on skin aging

Journal of Ginseng Research, 2020
Background: In aged skin, degradation of collagen fibers, which occupy the majority of the extracellular matrix in the dermis, and changes of aquaporin 3 (AQP3) and skin constituents, such as hyaluronic acid and ceramide, cause wrinkles and decrease skin
Ye Hyang Kim, Hye Rim Park, So Yoon Cha, So Hun Lee, Jung Wung Jo, Jung Nam Go, Kang Hyuk Lee, Su Yeon Lee, Song Seok Shin   +8 more
doaj   +1 more source

Antisense-mediated suppression of hyaluronan synthase 2 inhibits the tumorigenesis and progression of breast cancer [PDF]

, 2005
The progression of several cancers is correlated with the increased synthesis of the glycosaminoglycan, hyaluronan. Hyaluronan is synthesized at the plasma membrane by various isoforms of hyaluronan synthases (HAS).
Brownlee, Garry R., Thompson, Erik W., Blick, Tony, Brown, Tracey J., Brownlee, Gary R., Brown, Tracey J, Walker, Emma C., Nilsson, Susan K., Heldin, Paraskevi,, Heldin, Paraskevi, Udabage, Lishanthi, Waltham, Mark   +11 more
core   +1 more source