Results 41 to 50 of about 10,107 (167)

Evaluating The Effect of Melatonin on HAS2, and PGR expression, as well as Cumulus Expansion, and Fertility Potential in Mice

Cell Journal, 2018
Objective Infertility is a worldwide health problem which affects approximately 15% of sexually active couples. One of the factors influencing the fertility is melatonin.
Maryam Ezzati , Leila Roshangar, Jafar Soleimani, Nahid karimian   +3 more
doaj   +1 more source

Suppression of hyaluronan synthase 2 expression reflects the atrophogenic potential of glucocorticoids [PDF]

Experimental Dermatology, 2010
Please cite this paper as: Suppression of hyaluronan synthase 2 expression reflects the atrophogenic potential of glucocorticoids. Experimental Dermatology 2010; 19: 757–759.Abstract:  We recently demonstrated that dexamethasone, a strongly atrophogenic glucocorticoid (GC), downregulated hyaluronan (HA) production in human keratinocytes and ...
Marco, Averbeck, Carl, Gebhardt, Ulf, Anderegg, Jan C, Simon   +3 more
openaire   +2 more sources

Biological responses of three-dimensional cultured fibroblasts by sustained compressive loading include apoptosis and survival activity. [PDF]

PLoS ONE, 2014
Pressure ulcers are characterized by chronicity, which results in delayed wound healing due to pressure. Early intervention for preventing delayed healing due to pressure requires a prediction method.
Toshiki Kanazawa, Gojiro Nakagami, Takeo Minematsu, Takumi Yamane, Lijuan Huang, Yuko Mugita, Hiroshi Noguchi, Taketoshi Mori, Hiromi Sanada   +8 more
doaj   +1 more source

Keratinocyte Growth Factor Stimulates Migration and Hyaluronan Synthesis in the Epidermis by Activation of Keratinocyte Hyaluronan Synthases 2 and 3 [PDF]

Journal of Biological Chemistry, 2003
Keratinocyte growth factor (KGF) activates keratinocyte migration and stimulates wound healing. Hyaluronan, an extracellular matrix glycosaminoglycan that accumulates in wounded epidermis, is known to promote cell migration, suggesting that increased synthesis of hyaluronan might be associated with the KGF response in keratinocytes.
Susanna, Karvinen, Sanna, Pasonen-Seppänen, Juha M T, Hyttinen, Juha-Pekka, Pienimäki, Kari, Törrönen, Tiina A, Jokela, Markku I, Tammi, Raija, Tammi   +7 more
openaire   +2 more sources

Effect of vasopressin on the expression of genes for key enzymes of interstitial hyaluronan turnover and concentration ability in WAG rat kidneys

Вавиловский журнал генетики и селекции, 2016
In mammals, arginine-vasopressin (AVP) is a major hormone involved in the regulation of renal water reabsorption, acting via an increase in the osmotic permeability of the collecting duct epithelium.
L. N. Ivanova, A. V. Babina, G. S. Baturina, L. E. Katkova   +3 more
doaj   +1 more source

Methyl-β-cyclodextrin Suppresses Hyaluronan Synthesis by Down-regulation of Hyaluronan Synthase 2 through Inhibition of Akt [PDF]

Journal of Biological Chemistry, 2010
Hyaluronan synthases (HAS1-3) are integral plasma membrane proteins that synthesize hyaluronan, a cell surface and extracellular matrix polysaccharide necessary for many biological processes. It has been shown that HAS is partly localized in cholesterol-rich lipid rafts of MCF-7 cells, and cholesterol depletion with methyl-beta-cyclodextrin (MbetaCD ...
Anne, Kultti, Riikka, Kärnä, Kirsi, Rilla, Pertti, Nurminen, Elina, Koli, Katri M, Makkonen, Jutong, Si, Markku I, Tammi, Raija H, Tammi   +8 more
openaire   +2 more sources

Role of UDP-N-Acetylglucosamine (GlcNAc) and O-GlcNAcylation of Hyaluronan Synthase 2 in the Control of Chondroitin Sulfate and Hyaluronan Synthesis [PDF]

Journal of Biological Chemistry, 2012
Hyaluronan (HA) is a glycosaminoglycan present in most tissue microenvironments that can modulate many cell behaviors, including proliferation, migration, and adhesive proprieties. In contrast with other glycosaminoglycans, which are synthesized in the Golgi, HA is synthesized at the plasma membrane by one or more of the three HA synthases (HAS1-3 ...
VIGETTI, DAVIDE, DELEONIBUS, SARA, MORETTO, PAOLA, KAROUSOU, EVGENIA, VIOLA, MANUELA, BARTOLINI, BARBARA, Hascall VC, Tammi M, DE LUCA, GIANCARLO, PASSI, ALBERTO   +9 more
openaire   +3 more sources

Loss of Endothelial Glycocalyx Hyaluronan Impairs Endothelial Stability and Adaptive Vascular Remodeling after Arterial Ischemia

Cells, 2020
We recently reported that loss of hyaluronan (HA) from the endothelial glycocalyx leads to loss of vessel stability in specific microcirculatory vascular beds.
Gangqi Wang, Margreet R. de Vries, Wendy M. P. J. Sol, Annemarie M. van Oeveren-Rietdijk, Hetty C. de Boer, Anton Jan van Zonneveld, Paul H. A. Quax, Ton J. Rabelink, Bernard M. van den Berg   +8 more
doaj   +1 more source

Inverse expression of hyaluronidase 2 and hyaluronan synthases 1–3 is associated with reduced hyaluronan content in malignant cutaneous melanoma [PDF]

BMC Cancer, 2013
Hyaluronan is an extracellular matrix glycosaminoglycan involved in invasion, proliferation and metastasis of various types of carcinomas. In many cancers, aberrant hyaluronan expression implicates disease progression and metastatic potential. Melanoma is an aggressive skin cancer.
Siiskonen Hanna-Leena, Sironen Reijo Kalevi, Pasonen-Seppänen Sanna, Tyynelä-Korhonen Erja, Sironen Reijo   +4 more
openaire   +3 more sources

Kidney Hematopoietic Stem and Progenitor Cells Contribute to Myeloid Development and Pathology in Lupus Nephritis

Arthritis &Rheumatology, EarlyView.
Objective The hematopoietic system maintains homeostasis by balancing myeloid and lymphoid cell production in the bone marrow (BM). In response to increased hematopoietic demand, extramedullary hematopoiesis (EMH) may occur in nonlymphoid organs. We investigated the role of EMH and kidney‐resident hematopoietic stem and progenitor cells (HSPCs) in ...
Hansol Yi, Seyoung Jung, Jeong Ho Joo, Young‐Eun Kim, Heounjeong Go, Yong‐Gil Kim, Chang‐Keun Lee, Bin Yoo, Jeong Seok Lee, Seokchan Hong   +9 more
wiley   +1 more source