Results 31 to 40 of about 10,976 (205)

Hyaluronan Synthase: New Directions for Hyaluronan Research.

Trends in Glycoscience and Glycotechnology, 1998
今日、ヒアルロン酸は脊椎動物の様々な組織やある種の連鎖球菌の莢膜に広く存在することが知られており、また変形性関節症の関節腔内に注入される補充物として医学応用されるなど、その重要性は年々増加している。ヒアルロン酸は特に、胚時期の細胞増殖や運動性の活発化している組織で、細胞外マトリックスの主要な構成成分として存在し、ヒアルロン酸結合分子や細胞表面受容体との相互作用により、細胞の接着、移動、分化をダイナミックに調節する。さらにこの遍在する高分子は形態形成や再生、創傷治癒、癌の浸潤・転移といった多彩な生命現象に関与することが示されている。他方、ヒアルロン酸の生合成機構解明に向けた研究、特にヒアルロン酸合成酵素を単離し同定する試みが、連鎖球菌や動物細胞を材料に過去十年以上にわたって精力的に行われてきた ...
Naoki Itano, Koji Kimata
openaire   +3 more sources

Vulnerability to shear stress caused by altered peri-endothelial matrix is a key feature of Moyamoya disease

Scientific Reports, 2021
Moyamoya disease (MMD) is characterized by progressive bilateral stenotic changes in the terminal portion of the internal carotid arteries. Although RNF213 was identified as a susceptibility gene for MMD, the exact pathogenesis remains unknown ...
Muneaki Matsuo, Satomi Nadanaka, Minami Soga, Taku Sugiyama, Shota Serigano, Kenjiro Shimano, Fumio Ichinose, Takuji Nakamura, Toshiyuki Maeda, Kiyohiro Houkin, Takumi Era, Hiroshi Kitagawa   +11 more
doaj   +1 more source

Self-regenerating giant hyaluronan polymer brushes

Nature Communications, 2019
Polymer brushes are often used to functionalise surfaces. Here, the authors report on the creation of high-density, regenerating hyaluronan brushes using hyaluronan synthase enzymes which can be patterned by photo-deactivation and demonstrate ...
Wenbin Wei, Jessica L. Faubel, Hemaa Selvakumar, Daniel T. Kovari, Joanna Tsao, Felipe Rivas, Amar T. Mohabir, Michelle Krecker, Elaheh Rahbar, Adam R. Hall, Michael A. Filler, Jennifer L. Washburn, Paul H. Weigel, Jennifer E. Curtis   +13 more
doaj   +1 more source

SARS-CoV-2 RNA elements share human sequence identity and upregulate hyaluronan via NamiRNA-enhancer network

EBioMedicine, 2022
Summary: Background: Since late 2019, SARS-CoV-2 infection has resulted in COVID-19 accompanied by diverse clinical manifestations. However, the underlying mechanism of how SARS-CoV-2 interacts with host and develops multiple symptoms is largely ...
Wei Li, Shuai Yang, Peng Xu, Dapeng Zhang, Ying Tong, Lu Chen, Ben Jia, Ang Li, Cheng Lian, Daoping Ru, Baolong Zhang, Mengxing Liu, Cancan Chen, Weihui Fu, Songhua Yuan, Chenjian Gu, Lu Wang, Wenxuan Li, Ying Liang, Zhicong Yang, Xiaoguang Ren, Shaoxuan Wang, Xiaoyan Zhang, Yuanlin Song, Youhua Xie, Hongzhou Lu, Jianqing Xu, Hailin Wang, Wenqiang Yu   +28 more
doaj   +1 more source

Effect of diclofenac etalhyaluronate (SI-613) on the production of high molecular weight sodium hyaluronate in human synoviocytes

BMC Musculoskeletal Disorders, 2019
Background We have reported that a single intra-articular injection of diclofenac etalhyaluronate (SI-613) exerted a potent and long-lasting analgesic effect in experimental arthritis models.
Tomochika Kisukeda, Junichi Onaya, Keiji Yoshioka   +2 more
doaj   +1 more source

HAS2-Ezrin-ER axis plays a role in acquired antiestrogen resistance of ER-positive breast cancer

Frontiers in Pharmacology, 2022
The development of endocrine resistance is a major clinical problem in estrogen receptor-positive (ER+) breast cancer (BrCa) treatment, in which how cancer cells acquire resistance remains obscure.
Xiaodan Sun, Xiaodan Sun, Fen Tang, Qian Guo, Yiwen Liu, Yiqing He, Yan Du, Feng Gao, Feng Gao, Guoliang Zhang, Guoliang Zhang, Cuixia Yang, Cuixia Yang   +12 more
doaj   +1 more source

Role of hyaluronan and hyaluronan-binding proteins in human asthma.

, 2022
BackgroundThe characteristics of human asthma are chronic inflammation and airway remodeling. Hyaluronan, a major extracellular matrix component, accumulates during inflammatory lung diseases, including asthma.
Xie, Ting, Jiang, Dianhua, Liang, Jiurong, Ingram, Jennifer, Jung, Yoosun, Noble, Paul W, Church, Tony, Kraft, Monica, Degan, Simone, Leonard, Maura   +9 more
core   +1 more source

Hyaluronan synthase in trabecular meshwork cells [PDF]

British Journal of Ophthalmology, 2003
Hyaluronan is present in the trabecular meshwork where it is involved in the pathophysiology of aqueous outflow environment. In this study, the expression and regulation of hyaluronan synthase (HAS), which is the enzyme synthesising hyaluronan, in trabecular meshwork cells were investigated.Cultured bovine trabecular meshwork cells (BTMCs) were used ...
T, Usui, F, Nakajima, R, Ideta, Y, Kaji, Y, Suzuki, M, Araie, S, Miyauchi, P, Heldin, H, Yamashita   +8 more
openaire   +2 more sources

The role of the multifaceted long non-coding RNAs: A nuclear-cytosolic interplay to regulate hyaluronan metabolism

Matrix Biology Plus, 2021
In the extracellular matrix (ECM), the glycosaminoglycan (GAG) hyaluronan (HA) has different physiological roles favouring hydration, elasticity and cell survival.
Arianna Parnigoni, Ilaria Caon, Paola Moretto, Manuela Viola, Evgenia Karousou, Alberto Passi, Davide Vigetti   +6 more
doaj   +1 more source

Metabolic control of hyaluronan synthases

Matrix Biology, 2014
Hyaluronan (HA) is a glycosaminoglycan composed by repeating units of D-glucuronic acid (GlcUA) and N-acetylglucosamine (GlcNAc) that is ubiquitously present in the extracellular matrix (ECM) where it has a critical role in the physiology and pathology of several mammalian tissues.
VIGETTI, DAVIDE, VIOLA, MANUELA, KAROUSOU, EVGENIA, DE LUCA, GIANCARLO, PASSI, ALBERTO   +4 more
openaire   +3 more sources