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Hyaluronan synthases and hyaluronidases in nasal polyps [PDF]

European Archives of Oto-Rhino-Laryngology, 2015
Nasal polyps (NPs) are benign lesions of nasal and paranasal sinuses mucosa affecting 1-4 % of all adults. Nasal polyposis affects the quality of patient's life as it causes nasal obstruction, postnasal drainage, purulent nasal discharge, hyposmia or anosmia, chronic sinusitis, facial pain and snoring.
Demitrios H. Vynios, S. Filou, T. Panogeorgou, E. Tserbini, Panos Goumas, N. S. Mastronikolis, Stephanos Naxakis, T A Papadas   +7 more
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Hyaluronan and hyaluronan synthases expression and localization in embryonic mouse molars

Journal of Molecular Histology, 2016
Hyaluronan (HA) and hyaluronan synthases (HASs) have been shown to play critical roles in embryogenesis and organ development. However, there have not been any studies examining HA and HAS expression and localization during tooth development. The present study was designed to investigate the expression of HA and three isoforms of HASs (HAS1, 2, 3) in ...
Guofeng Yang, Shouliang Zhao, Shouliang Zhao, Wenping Cai, Beizhan Jiang, Shangfeng Liu   +5 more
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Hyaluronan Synthases Posttranslational Regulation in Cancer

Advances in Cancer Research, 2014
Hyaluronan (HA) is a critical component of cancer microenvironment that is known to increase tumor progression and aggressiveness. The synthesis of HA starts from the cytosolic precursors UDP-N-acetylglucosamine and UDP-glucuronic acid. These two sugar nucleotides have several functions in addition to glycoconjugate synthesis and glucuronidation ...
VIGETTI, DAVIDE, PASSI, ALBERTO
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Exploiting the diversity of streptococcal hyaluronan synthases for the production of molecular weight–tailored hyaluronan

Applied Microbiology and Biotechnology, 2019
The molecular weight (Mw) of hyaluronic acid (HA) determines its suitability for medical and cosmetic applications. Here, we characterize in vitro and in vivo HA synthesis of streptococcal HA synthases (HASs) with a special focus on HA Mw. To date, four streptococcal HA producers are described (Streptococcus equi subsp. equi, S.
Sandra Schulte, Sreeja Shanmuga Doss, Lars M. Blank, Lars M. Blank, Mythili Ananth, Guhan Jayaraman, Pandeeswari Jeeva   +6 more
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Role of hyaluronan and hyaluronan synthase in endometrial cancer

Oncology Reports, 2005
The aim of this study was to determine if the immunohistochemical expression of hyaluronan synthase (HAS) and serum levels of hyaluronan correlate with the clinicopathological manifestations of endometrial carcinoma. Sera were obtained from 59 endometrial cancer patients and 22 post-menopausal healthy women.
Tameko Kishida, Kanako Fusano, Lisheng Zhuo, Hiromitsu Yabushita, Masayoshi Noguchi, Koji Kimata, Naoki Itano, Kouhei Kanyama   +7 more
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The Hyaluronan Synthase Catalyzes the Synthesis and Membrane Translocation of Hyaluronan

Journal of Molecular Biology, 2012
Hyaluronan (HA), an extracellular linear polysaccharide of alternating N-acetyl-glucosamine and glucuronic acid residues, is ubiquitously expressed in vertebrates, where it affects a broad spectrum of physiological processes, including cell adhesion, migration and differentiation. The HA polymer is synthesized on the cytosolic side of the cell membrane
Joshua T. McNamara, Caitlin Hubbard, Caleigh M. Azumaya, Jochen Zimmer, Mehul S. Patel   +4 more
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Hyaluronan and Hyaluronan Synthases: Potential Therapeutic Targets in Cancer

Current Drug Target -Cardiovascular & Hematological Disorders, 2005
Current models of oncogenesis describe cancer as a progression of genetic mutations in a tumor cell mass. However, tumors are more than a clonal expansion of malignant cells. Tumors are heterogeneous, with a complex 3D structure, analogous to organs comprised of different tissues.
Linda M. Pilarski, Sophia Adamia, Christopher A. Maxwell   +2 more
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Analysis of Hyaluronan Synthase Activity

2014
Hyaluronan (HA) is a component of the extracellular matrix that is involved in many physiological and pathological processes. As HA modulates several functions (i.e., cell proliferation and migration, inflammation), its presence in the tissues can have positive or negative effects.
Davide Vigetti, Evgenia Karousou, Manuela Viola, Alberto Passi   +3 more
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Aberrant splicing, hyaluronan synthases and intracellular hyaluronan as drivers of oncogenesis and potential drug targets.

Current Cancer Drug Targets, 2013
Current evidence suggests a significant role of aberrant splicing in the development and maintenance of malignancy. This multistep, tightly regulated epigenetic process leads to the production of abnormal proteins with abnormal functions contributing to ...
Sophia Adamia, P. Pilarski, A. Belch, L. Pilarski   +3 more
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Molecular Cloning of Human Hyaluronan Synthase

Biochemical and Biophysical Research Communications, 1996
We report here the cDNA sequence of human hyaluronan synthase. The cDNA clone was isolated from a human fetal brain cDNA library by screening with a DNA probe generated from the coding sequence of murine hyaluronan synthase. It contains a 2107 bp cDNA insert which is composed of a 1629 bp open reading frame and a short segment of the 3'-untranslated ...
Koji Kimata, Naoki Itano
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