Results 241 to 250 of about 265,910 (261)

Hyaluronan synthase expression in ovarian cancer

Oncology Reports, 2004
To determine if the immunohistochemical expression of hyaluronan synthase (HAS) correlates with the clinicopathological manifestations or clinical outcomes of ovarian carcinoma, sections of tumor tissue from 33 ovarian cancer patients were immunostained by the avidin-biotin-peroxidase complex method using anti-HAS1, anti-HAS2, anti-HAS3 and anti-CD44 ...
Tameko Kishida, Kanako Fusano, Masayoshi Noguchi, Koji Kimata, Naoki Itano, Yasuyuki Noguchi, Hiromitsu Yabushita, Mari Noguchi   +7 more
openaire   +3 more sources

Hyaluronan Synthases in Normal and Regenerating Joint Cartilage

Cells Tissues Organs, 2003
Repair of full thickness joint cartilage defects is within reach of routine clinical practice. The quality of regenerating hyaline cartilage, however, is difficult to assess. Synthesis of an extracellular matrix with high hyaluronan content is crucial for its metabolic and functional properties.
Mrosek, Eike Herbert, Erggelet, Christoph, McDonald, John A., Kurz, Haymo   +3 more
openaire   +4 more sources

A Nonradioactive Method to Measure Hyaluronan Synthase Activity

2021
Hyaluronan (HA) is a component of the extracellular matrix that is involved in many physiological and pathological processes. As HA modulates several functions (i.e., cell proliferation and migration, inflammation), its presence in the tissues can have positive or negative effects.
Evgenia Karousou, Davide Vigetti, Alberto Passi, Manuela Viola   +3 more
openaire   +2 more sources

Regulation of hyaluronan synthases in mouse uterine cervix

Biochemical and Biophysical Research Communications, 2005
We examined the expression pattern of hyaluronan synthase (HAS) mRNAs in the uterine cervix of pregnant mice. The expression levels of HAS-1 and -2 mRNAs peaked at delivery, whereas that of HAS-3 mRNA peaked on the 15th day of pregnancy. The regulation of HAS mRNA expression was examined in pregnant mouse uterine cervical fibroblasts. The expression of
Tomohiro Sakuta, Toshiji Kanayama, Taro Uchiyama   +2 more
openaire   +3 more sources

Hyaluronan Synthase Assay

2009
Hyaluronan (HA) is a polysaccharide composed of repeating GlcNAcβ(1 → 4)- GlcUAβ(1 → 3) disaccharide units. This polysaccharide has a molecular mass ranging from 103 to 107 Da, depending on the tissue source and physiological conditions. Three members of the HA synthase family, HAS1, HAS2 and HAS3, have been thus far identified in a wide variety of ...
openaire   +2 more sources

Abnormal expression of hyaluronan synthases in patients with Waldenstrom's macroglobulimenia.

Seminars in Oncology, 2003
Little is known about the biology or spread of Waldenstrom's macroglobulinemia (WM), a lymphoplasmo-proliferative disorder. Hyaluronan synthases (HASs), plasma membrane proteins, synthesize the extracellular matrix molecule hyaluronan (HA), which plays a
Sophia Adamia, M. Crainie, J. Kriangkum, M. Mant, A. Belch, L. Pilarski   +5 more
semanticscholar   +1 more source

Hyaluronan synthase expression in pleural malignant mesotheliomas

Virchows Archiv, 2005
Hyaluronan (HA) is thought to play several important roles in tumor growth, tumorigenicity, and tumor dissemination and metastasis. Recently, three isoforms of hyaluronan synthase (HAS) have been cloned. Our objective was to determine which of the HAS isoforms were expressed in pleural malignant mesotheliomas, the most representative lesion of HA ...
Koji Kimata, Naoki Itano, Tomoyuki Kamijo, Takahiro Hasebe, Atsushi Ochiai, Tomoyuki Yokose, Naoki Kanomata, Hiroyuki Yonou   +7 more
openaire   +3 more sources

Chondroitin sulfate increases hyaluronan production by human synoviocytes through differential regulation of hyaluronan synthases: Role of p38 and Akt.

Arthritis & Rheumatism, 2009
OBJECTIVE To uncover the mechanism by which chondroitin sulfate (CS) enhances hyaluronan (HA) production by human osteoarthritic (OA) fibroblast-like synoviocytes (FLS).
M. David-Raoudi, B. Deschrevel, S. Leclercq, P. Galéra, K. Boumediene, J. Pujol   +5 more
semanticscholar   +1 more source

Hyaluronan Synthases, Hyaluronan and Its CD44 Receptors in the Posterior Segment of Rabbit Eye

Ophthalmologica, 2005
To understand the possible roles of the hyaluronan synthetase (HAS)/hyaluronan (HA)/CD44 signaling system in the posterior eye segment, we investigated the expression of rabbit HAS isoforms and CD44 mRNA by RT-PCR and the level of HA by using HA assay and immunohistochemistry. HA was detectable in vitreous, retina and choroid.
Masatoshi Murata, Saburo Horiuchi
openaire   +3 more sources

Hyaluronan Synthase-1, -2, and -3

2002
Hyaluronan (HA) is a high-molecular-weight linear polysaccharide composed of β-1,4-linked repeating disaccharides of glucuronic acid β-1,3-linked to N- acetylglucosamine. It is found in the extracellular matrices of most vertebrate tissues and in the capsules of certain bacterial pathogens.
openaire   +2 more sources