Results 31 to 40 of about 5,143 (259)

Hyaluronan and Hyaluronidase, which is better for embryo development? [PDF]

, 2016
Our aim was to examine size-specific effects of Hyaluronan (HA) on preimplantation embryo development. We investigated the effects of Hyalovet (HA, 500–750 kDa; the size produced by HA synthase-3, which is abundant in the oviduct), or HA treated with ...
Ali A. Fouladi-Nashta, Aruffo, Aviles, Bastow, Bergqvist, Block, Bourguignon, Choudhary, Csoka, Dicker, Fenwick, Fouladi-Nashta, Furnus, Furnus, Georgiou, Hahnel, Hess, Kabir A. Raheem, Lane, Laurent, Lesley, Lloyd, Marei, Marei, Mariani, Matwee, Mazdak Salavati, Mehta, Mohey-Elsaeed, Muhammad Khalid, Neira, Oesterreicher, Ohno-Nakahara, Pandey, Pushpakumara, Raheem, Robinson, Rozen, Russell, Ryan, Saliba, Schmidt, Seytanoglu, Stern, Stevenson, Tienthai, Tina Tremaine, Tombolan, Toole, Torner, Ulbrich, Waleed F.A. Marei, Wang, Wathes, Watson, Way, Weigel, Xu, Yevdokimova, Yoon   +59 more
core   +2 more sources

The Content and Size of Hyaluronan in Biological Fluids and Tissues

Frontiers in Immunology, 2015
Hyaluronan is a simple repeating disaccharide polymer, synthesized at the cell surface by integral membrane synthases. The repeating sequence is perfectly homogeneous, and is the same in all vertebrate tissues and fluids.
Mary K. Cowman, Hong-Gee eLee, Kathryn L. Schwertfeger, James B. McCarthy, Eva A. Turley   +4 more
doaj   +1 more source

Synthesis of heparosan oligosaccharides by Pasteurella multocida PmHS2 single-action transferases [PDF]

, 2012
Pasteurella multocida heparosan synthase PmHS2 is a dual action glycosyltransferase that catalyzes the polymerization of heparosan polymers in a non-processive manner.
Boeriu, C.G., Broek, L.A.M., van den, Chavaroche, A.A.E., Eggink, G.   +3 more
core   +2 more sources

Ultraviolet irradiation induces the accumulation of chondroitin sulfate, but not other glycosaminoglycans, in human skin. [PDF]

PLoS ONE, 2011
Ultraviolet (UV) light alters cutaneous structure and function. Prior work has shown loss of dermal hyaluronan after UV-irradiation of human skin, yet UV exposure increases total glycosaminoglycan (GAG) content in mouse models.
Benjamin Boegel Werth, Muhammad Bashir, Laura Chang, Victoria P Werth   +3 more
doaj   +1 more source

Hyaluronan Synthase 3 Regulates Hyaluronan Synthesis in Cultured Human Keratinocytes [PDF]

Journal of Investigative Dermatology, 2002
Three human hyaluronan synthase genes (HAS1, HAS2, and HAS3) have been cloned, but the functional differences between these HAS genes remains obscure. The purpose of this study was to examine which of the HAS genes are selectively regulated in epidermis.
Sayo, Tetsuya, Sugiyama, Yoshinori, Takahashi, Yoshito, Ozawa, Naoko, Sakai, Shingo, Inoue, Shintaro, Ishikawa, Osamu, Tamura, Masaaki   +7 more
openaire   +2 more sources

ΔNp63-mediated regulation of hyaluronic acid metabolism and signaling supports HNSCC tumorigenesis [PDF]

, 2017
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide, and several molecular pathways that underlie the molecular tumorigenesis of HNSCC have been identified. Among them, amplification or overexpression of ΔNp63 isoforms
Anemone, Lucia, Bongiorno-Borbone, Lucilla, Compagnone, Mirco, Fierro, Claudia, Gatti, Veronica, Markert, Elke Katrin, Mauriello, Alessandro, Melino, Gerry, Peschiaroli, Angelo, Presutti, Dario, Ruberti, Giovina, Vousden, Karen H, Zhou, Huiqing   +12 more
core   +2 more sources

Hyaluronan synthase in trabecular meshwork cells [PDF]

British Journal of Ophthalmology, 2003
Hyaluronan is present in the trabecular meshwork where it is involved in the pathophysiology of aqueous outflow environment. In this study, the expression and regulation of hyaluronan synthase (HAS), which is the enzyme synthesising hyaluronan, in trabecular meshwork cells were investigated.Cultured bovine trabecular meshwork cells (BTMCs) were used ...
T, Usui, F, Nakajima, R, Ideta, Y, Kaji, Y, Suzuki, M, Araie, S, Miyauchi, P, Heldin, H, Yamashita   +8 more
openaire   +2 more sources

Lung Hyaluronasome: Involvement of Low Molecular Weight Ha (Lmw-Ha) in Innate Immunity

Biomolecules, 2022
Hyaluronic acid (HA) is a major component of the extracellular matrix. It is synthesized by hyaluronan synthases (HAS) into high-molecular-weight chains (HMW-HA) that exhibit anti-inflammatory and immunomodulatory functions.
Antony Hoarau, Myriam Polette, Christelle Coraux   +2 more
doaj   +1 more source

Chain Gangs: New Aspects of Hyaluronan Metabolism

Biochemistry Research International, 2012
Hyaluronan is a matrix polymer prominent in tissues undergoing rapid growth, development, and repair, in embryology and during malignant progression. It reaches 107 Daltons in size but also exists in fragmented forms with size-specific actions.
Michael Erickson, Robert Stern
doaj   +1 more source

Elevated expression of hyaluronan synthase 2 associates with decreased survival in diffusely infiltrating astrocytomas

BMC Cancer, 2018
Background Diffusely infiltrating astrocytomas originate from astrocytic glial cells or their precursor cells and are the most common type of brain tumors in adults. In this retrospective study, we investigated the content of hyaluronan, its cell surface
Mari Valkonen, Hannu Haapasalo, Kirsi Rilla, Kristiina Tyynelä-Korhonen, Ylermi Soini, Sanna Pasonen-Seppänen   +5 more
doaj   +1 more source