Results 31 to 40 of about 2,588 (196)
Lung Hyaluronasome: Involvement of Low Molecular Weight Ha (Lmw-Ha) in Innate Immunity
Biomolecules, 2022 Hyaluronic acid (HA) is a major component of the extracellular matrix. It is synthesized by hyaluronan synthases (HAS) into high-molecular-weight chains (HMW-HA) that exhibit anti-inflammatory and immunomodulatory functions.
Antony Hoarau +2 more
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The role of hyaluronan in renal cell carcinoma
Frontiers in Immunology, 2023 Renal cell carcinoma (RCC) is associated with high mortality rates worldwide and survival among RCC patients has not improved significantly in the past few years.
Chenchen Jin, Yunfeng Zong
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Hyaluronan Synthase 3 Regulates Hyaluronan Synthesis in Cultured Human Keratinocytes [PDF]
Journal of Investigative Dermatology, 2002 Three human hyaluronan synthase genes (HAS1, HAS2, and HAS3) have been cloned, but the functional differences between these HAS genes remains obscure. The purpose of this study was to examine which of the HAS genes are selectively regulated in epidermis.
Tetsuya Sayo +7 more
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Chain Gangs: New Aspects of Hyaluronan Metabolism
Biochemistry Research International, 2012 Hyaluronan is a matrix polymer prominent in tissues undergoing rapid growth, development, and repair, in embryology and during malignant progression. It reaches 107 Daltons in size but also exists in fragmented forms with size-specific actions.
Michael Erickson, Robert Stern
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BMC Cancer, 2018 Background Diffusely infiltrating astrocytomas originate from astrocytic glial cells or their precursor cells and are the most common type of brain tumors in adults. In this retrospective study, we investigated the content of hyaluronan, its cell surface
Mari Valkonen +5 more
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Hyaluronan synthase in trabecular meshwork cells [PDF]
British Journal of Ophthalmology, 2003 Hyaluronan is present in the trabecular meshwork where it is involved in the pathophysiology of aqueous outflow environment. In this study, the expression and regulation of hyaluronan synthase (HAS), which is the enzyme synthesising hyaluronan, in trabecular meshwork cells were investigated.Cultured bovine trabecular meshwork cells (BTMCs) were used ...
Tomohiko Usui +8 more
openaire +2 more sources
BMC Cancer, 2009 Background Hyaluronan, a tumor promoting extracellular matrix polysaccharide, is elevated in malignant epithelial ovarian tumors, and associates with an unfavorable prognosis.
Heikkinen Anna-Mari +9 more
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Cancer Cell International, 2021 Background Non-small cell lung cancers (NSCLC) account for most cases of lung cancer. More effort is needed to research new drug and combination therapies for this disease. An anthraquinone derivative, emodin shows anticancer potency.
Mingzhu Li +5 more
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Correlative Light and Electron Microscopy Reveals the HAS3-Induced Dorsal Plasma Membrane Ruffles
International Journal of Cell Biology, 2015 Hyaluronan is a linear sugar polymer synthesized by three isoforms of hyaluronan synthases (HAS1, 2, and 3) that forms a hydrated scaffold around cells and is an essential component of the extracellular matrix.
Kirsi Rilla, Arto Koistinen
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The control and importance of hyaluronan synthase expression in palatogenesis [PDF]
Frontiers in Physiology, 2013 Development of the lip and palate involves a complex series of events that requires the close co-ordination of cell migration, growth, differentiation, and apoptosis. Palatal shelf elevation is considered to be driven by regional accumulation and hydration of glycosoaminoglycans, principally hyaluronan (HA), which provides an intrinsic shelf force ...
Galloway, Jennifer L +3 more
openaire +5 more sources