Results 91 to 100 of about 77,142 (304)

Increased Blood Flow and Tendon Swelling Precedes Vascular Expansion and Tissue Matrix Changes In Early Human Tendinopathy: A Potential Window for Superior Treatment Response

Advanced Science, EarlyView.
Human participants with early‐ or chronic‐stage tendinopathy and healthy controls are investigated using ultrasound Doppler, 3T and 7T MRI, and tendon biopsies. Tendon swelling and hyperperfusion are evident early, while vascular growth and extracellular matrix changes are most pronounced in chronic tendinopathy. Early intervention may provide superior
Max F. R. Merkel, Nikolaj M. Malmgaard‐Clausen, Marius Lendal, Hartwig R. Siebner, René B. Svensson, Stephanie G. Dakin, Marcus Krüger, Luisa Schmidt, Jakob Agergaard, Ching‐Yan Chloé Yeung, S. Peter Magnusson, Michael Kjaer   +11 more
wiley   +1 more source

Experimental Study of The Pharmacokinetics of Cefotaxime with Joint Administration of Drugs with Hyaluronidase Activity

Антибиотики и Химиотерапия, 2020
It Is shown that the preliminary administration of drugs that promote the flow of antibiotics into the lymphatic system increases the clinical effectiveness of treatment.
M. V. Zhuravleva, G. V. Kukushkin, L. P. Sviridkina, D. E. Yurov, T. R. Kameneva   +4 more
doaj   +1 more source

Transcriptomic analysis of Ascaris suum larvae during their hepatopulmonary migration [PDF]

, 2012
Common roundworms are important intestinal nematodes of man (Ascaris lumbricoides) and pig (Ascaris suum). During the first stages of the infection, the larvae of these parasites undergo a hepatopulmonary migration.
Gasser, Robin, Geldhof, Peter, Jex, Aaron, Vlaminck, Johnny, Wang, Tao   +4 more
core   +1 more source

Six months follow up of a single intravitreal injection of ocriplasmin for symptomatic vitreomacular adhesion [PDF]

, 2016
Purpose: To evaluate the efficacy and the safety of the enzymatic vitreolysis with a single intravitreal injection of ocriplasmin 125 μg across a group of patients with symptomatic vitreomacular adhesion (sVMA) during 6 months follow up.
GUZZO, Anna Santa, Mollicone, Antonella, Nikolakopoulos, Athanasios, Nikolakopoulos, Kostantinos, PACELLA, Elena, PACELLA, FERNANDA, SECONDI, ROBERTO   +6 more
core   +2 more sources

Hyaluronidase: from clinical applications to molecular and cellular mechanisms

European Journal of Medical Research, 2016
Over the past 60 years, hyaluronidase has been successfully utilized in ophthalmic surgery and is now being implemented in dermatosurgery as well as in other surgical disciplines. The enzyme is considered a “spreading factor” as it decomplexes hyaluronic
B. Buhren, H. Schrumpf, N. Hoff, E. Bölke, Said Hilton, P. Gerber   +5 more
semanticscholar   +1 more source

The KDM6B/SLC10A2 Axis Suppresses MDSCs Recruitment via ERK/AP‐1 Signaling in Colorectal Cancer

Advanced Science, EarlyView.
In wild‐type intestinal epithelial cells, KDM6B demethylates SLC10A2 to promote its expression, after which SLC10A2 suppresses ERK phosphorylation, inhibiting AP‐1 (Fos/Jun) transcription and chemokine production. In KDM6B‐deficient intestinal epithelial cells, SLC10A2 methylation increases, and its expression decreases.
Zhibo Hu, Jing Xun, Bin Liu, Xiaolin Jiang, Yingdi Han, Huichao Yang, Qi Gao, Ruifang Gao, Aimin Zhang, Xueliang Wu, Dapeng Zhang, Dihua Li, Tian Li, Shimin Yang, Ximo Wang, Xiangyang Yu, Qi Zhang   +16 more
wiley   +1 more source

ΔNp63-mediated regulation of hyaluronic acid metabolism and signaling supports HNSCC tumorigenesis [PDF]

, 2017
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide, and several molecular pathways that underlie the molecular tumorigenesis of HNSCC have been identified. Among them, amplification or overexpression of ΔNp63 isoforms
Anemone, Lucia, Bongiorno-Borbone, Lucilla, Compagnone, Mirco, Fierro, Claudia, Gatti, Veronica, Markert, Elke Katrin, Mauriello, Alessandro, Melino, Gerry, Peschiaroli, Angelo, Presutti, Dario, Ruberti, Giovina, Vousden, Karen H, Zhou, Huiqing   +12 more
core   +2 more sources

Irradiated Tumor Cell‐Derived Microparticles Activate Systemic Anti‐Tumor Immunity via the STING/NLRP3/GSDMD Axis in Neutrophils

Advanced Science, EarlyView.
Radiotherapy induces tumor cells to release microparticles (RT‐MPs) into the circulation. The mitochondrial DNA carried by these RT‐MPs activates the STING/NLRP3/GSDMD axis in splenic neutrophils, triggering IL‐1β secretion. This, in turn, enhances dendritic cell function and facilitates the formation of cytotoxic T lymphocytes, thereby promoting ...
Yan Hu, Jiacheng Wang, Mengjie Che, Zheng Yang, Jingshu Meng, Xiao Yang, Yue Deng, Zhiyuan Zhou, Yijun Wang, Wenwen Wei, Zhanjie Zhang, Bian Wu, You Qin, Kunyu Yang, Honglin Jin, Fang Huang, Yajie Sun, Lu Wen, Chao Wan   +18 more
wiley   +1 more source

Considerations for Proper Use of Hyaluronidase in the Management of Hyaluronic Acid Fillers

Plastic and Reconstructive Surgery, Global Open
Summary:. Effective management of complications from hyaluronic acid (HA) fillers is crucial in aesthetic medicine. This article examined the role of hyaluronidase in addressing adverse effects associated with HA fillers, such as nodules, vascular ...
Kyu-Ho Yi, MD, PhD, Jovian Wan, MBChB, Song Eun Yoon, MD   +2 more
doaj   +1 more source

Cutaneos larva migrans in travelers [PDF]

, 1994
The symptoms, medical history, and treatment of 98 patients with cutaneous larva migrans (creeping eruption) who attended a travel-related-disease clinic during a period of 4 years are reviewed.
Jelinek, Thomas, Löscher, Thomas, Maiwald, H., Nothdurft, H. D.   +3 more
core