Results 131 to 140 of about 77,142 (304)

Nanomedicine Meets Immunotherapy: Transforming Chimeric Antigen Receptor T Cell Treatment for Solid Tumors

Small Science, EarlyView.
This review highlights recent advances in nanomedicine that enhance chimeric antigen receptor (CAR) T cell therapy against solid tumors. It discusses key barriers to CAR T cell efficacy and outlines nanotechnology‐based strategies to improve tumor targeting, remodel the immunosuppressive microenvironment, and integrate nanomaterials into CAR T cell ...
Stephen O’Rourke, Nuo Xu, Hongjun Wang, Hexin Chen   +3 more
wiley   +1 more source

Potential clinical utility of small extracellular vesicles derived from head and neck tumours

VIEW, EarlyView.
Small extracellular vesicles (EVs) carry selective protein cargoes that reflect tumour cell status, making them valuable for biomarker discovery. This study compared EV proteomes from head and neck cancer (HNC) tumour tissue, saliva and plasma. Over 60% of proteins were shared across all sources, with enrichment in cancer‐related pathways such as ...
Abolfazl Jangholi, B. W. M. Thilini J. Basnayake, Omar Breik, Lizbeth Kenny, Sarju Vasani, Riccardo Dolcetti, Chamindie Punyadeera   +6 more
wiley   +1 more source

Comparison of the effects of submucosal hyaluronidase and dexamethasone on postoperative edema, pain, trismus, and infection following impacted third molar surgery

BMC Oral Health
Background Limiting postoperative edema, pain, trismus, and infection is crucial for smooth healing. This prospective, controlled clinical trial investigated and compared the effectiveness of dexamethasone and hyaluronidase in relieving these ...
Onur Koç, Nuray Er, Çiğdem Karaca, Kanİ Bilginaylar   +3 more
doaj   +1 more source

Efficacy of adding hyaluronidase to bupivacaine in ultrasound guided transversus abdominis plane block for postoperative analgesia after abdominal hysterectomy

Al-Azhar Assiut Medical Journal
Background and aim Transversus abdominis plane (TAP) blockade is a good method for the management of agonizing postoperative pain. As various nerves can be blocked in a sole prick, using hyaluronidase enzyme may progress the spread of the local ...
Mohamed M. Abo El Enain, Abd El-Rahman S.N. Abd El-Haleem, Osama H. Ahmed, Mohammed A.-S. Abdo Abu Hatab   +3 more
doaj   +1 more source

Hyaluronidase Iontophoresis [PDF]

Physical Therapy, 1969
openaire   +2 more sources

Mouse genome engineering uncovers 18 genes dispensable for male reproduction

Andrology, EarlyView.
Abstract Background Male infertility is an intricate multifactorial disease involving the interplay between genetic and environmental factors. Genetic anomalies account for more than 15% of all male infertility cases; however, diagnosing them exhibits enormous challenges due to variable symptomatic presentations and limited knowledge of gene functions.
Hsin‐Yi Chang, Yonggang Lu, Kaito Yamamoto, Jiang Sun, Keisuke Shimada, Yuki Hiradate, Yoshitaka Fujihara, Masahito Ikawa   +7 more
wiley   +1 more source

Transcription Factor TCF12‐Mediated Maternal Gene Expressions in Mouse Oocyte Are Prerequisites of Successful Fertilisation and Zygotic Genome Activation

Cell Proliferation, EarlyView.
Maternal TCF12 ensures the competence of fertilisation by controlling the expression of Astl and the proper location of cortical granules. Furthermore, maternal TCF12 maintains the phosphatase activity of PP2A by regulating the expression of Arpp19. Oocyte‐specific deletion of Tcf12 leads to fertilisation defects as well as ZGA failure at the 2‐cell ...
Lan‐Rui Cao, Chi Zhang, Zuo‐Qi Deng, Yue‐xin Qiu, Zhao Zhang, Heng‐Yu Fan, Jing Li, Hong‐Bo Wu   +7 more
wiley   +1 more source

Efficacy of oral colchicine and intralesional hyaluronidase with and without ultrasound therapy in the management of oral submucous fibrosis—A comparative study

Journal of Pharmacy and Bioallied Sciences
Aim: To determine the therapeutic effect and efficacy of oral colchicine tablet and intralesional injection of hyaluronidase with and without ultrasound therapy in the clinical course of oral submucous fibrosis.
Malabika Shil, Poulami Goswami, Trupti Vijay Gaikwad, Gargi Jadaun, T Sridhar, Basudhara Bandyopadhyay, Pratik Surana   +6 more
doaj   +1 more source

Unwelcome neighbours: Tracking the transmission of Streptococcus equi in the United Kingdom horse population

Equine Veterinary Journal, EarlyView.
Abstract Background Strangles (Streptococcus equi infection) remains endemic in the UK, with ~300 laboratory diagnoses annually. Sub‐clinically infected long‐term carriers are considered a key driver of endemicity. Analysing genomes of circulating strains could provide valuable transmission insights of this pathogen.
Abigail A. McGlennon, Kristien L. Verheyen, J. Richard Newton, Andries van Tonder, Hayley Wilson, Julian Parkhill, Nicolas de Brauwere, Sara Frosth, Andrew S. Waller   +8 more
wiley   +1 more source

Abnormal cleavage patterns in equine in vitro‐produced embryos lead to higher early pregnancy loss

Equine Veterinary Journal, EarlyView.
Summary Background Despite significant advances, in vitro production (IVP) of equine embryos continues to lack standardised embryo classification criteria and is associated with increased rates of early pregnancy loss compared with in vivo‐derived blastocysts.
Soledad Martin‐Pelaez, Alejandro de la Fuente, Kazuki Takahashi, Hugo Monteiro, Mauricio Mendes, Stuart Meyers, Pouya Dini   +6 more
wiley   +1 more source