Results 31 to 40 of about 42,196 (203)

Enhancing In Vivo Electroporation Efficiency through Hyaluronidase: Insights into Plasmid Distribution and Optimization Strategies

Pharmaceutics
Electroporation (EP) stands out as a promising non-viral plasmid delivery strategy, although achieving optimal transfection efficiency in vivo remains a challenge.
Debnath Maji, Verónica Miguela, Andrew D. Cameron, Delcora A. Campbell, Linda Sasset, Xin Yao, Andy T. Thompson, Carleigh Sussman, David Yang, Robert Miller, Marek M. Drozdz, Rachel A. Liberatore   +11 more
doaj   +1 more source

Inhibition of Tityus serrulatus venom hyaluronidase affects venom biodistribution.

PLoS Neglected Tropical Diseases, 2019
BackgroundThe hyaluronidase enzyme is generally known as a spreading factor in animal venoms. Although its activity has been demonstrated in several organisms, a deeper knowledge about hyaluronidase and the venom spreading process from the bite/sting ...
Bárbara Bruna Ribeiro de Oliveira-Mendes, Sued Eustáquio Mendes Miranda, Douglas Ferreira Sales-Medina, Bárbara de Freitas Magalhães, Yan Kalapothakis, Renan Pedra de Souza, Valbert Nascimento Cardoso, André Luís Branco de Barros, Clara Guerra-Duarte, Evanguedes Kalapothakis, Carolina Campolina Rebello Horta   +10 more
doaj   +1 more source

Design and preparation of chimeric hyaluronidase as a chaperone for the subcutaneous administration of biopharmaceuticals

, 2016
Subcutaneous (SC) delivery of biomacromolecular pharmaceuticals such as proteins often encounter barriers in the extracellular matrix, especially the hyaluronan (HA) network.
Xie, Bo, Hui, Mizhou, Wei, Wei, Liu, Shan, Su, Zhiguo   +4 more
core   +1 more source

Cloning and Characterization of Phospholipases A2 and Hyaluronidase Genes from the Venom of the Honeybee Apis mellifera carnica (Hymenoptera: Apidae)

Sociobiology, 2014
Bee venom contains the allergic enzymes phospholipases A2 (PLA2) and hyaluronidase. These enzymes have been extensively studied as therapeutic modalities because of their proven effects in pharmaceutical and clinical applications.
Junfang Lin
doaj   +1 more source

Effects of photobiomodulation on wound contraction in rats undergoing doxorubicin extravasation: a histomorphometric analysis

Revista da Escola de Enfermagem da USP, 2021
Objective: To analyze wound contraction and histomorphometric pattern of lesions in Wistar rats undergoing doxorubicin extravasation. Method: Sixty adult female rats were used, divided into four groups of fifteen animals: Group 1 (Control, without ...
Karina Alexandra Batista da Silva Freitas, Noeme Sousa Rocha, Eliana Maria Minicucci, Valéria Flávia Batista da Silva, Hélio Langoni, Regina Célia Popim   +5 more
doaj   +2 more sources

Hyaluronidase in Dermatology:Uses Beyond Hyaluronic Acid Fillers

, 2020
Hyaluronidase is mostly widely recognized for its off-label use in correction of complications of hyaluronic acid fillers. However, its utility in other aspects of dermatology is less widely acknowledged.
Al-Niaimi, Firas, Searle, Tamara, Ali, Faisal R   +2 more
core   +1 more source

Vision-threatening reactions of hyaluronidase after local anesthesia: A case series and review of literature

Indian Journal of Ophthalmology. Case Reports, 2023
Hyaluronidase is an often used drug in ophthalmology to enhance the effect of local anesthesia. Hypersensitivity reaction to hyaluronidase is a rare complication. Various cases showing varied presentations have been reported in the literature.
Arti Singh, Kamaljeet Singh, Jagriti Rana, Upasna Singh, Anirrud Sharma, Vineet Kumar   +5 more
doaj   +1 more source

Interfacial behaviour of bovine testis hyaluronidase

, 2006
International audienceThe interfacial properties of bovine testicular hyaluronidase were suggested by demonstrating the association of hyaluronidase activity with membranes prepared from bovine testis.
Besson, Françoise, Lancelin, Jean-Marc, Salim, Vera M., Alves, Tito L. M., Belem-Gonçalves, Silvia, Tsan, Pascale   +5 more
core   +1 more source

Clostridium difficile and its toxins [PDF]

, 1974
An investigation of Clostridium difficile has shown : 1. that the organism is resistant to cresols and phenolq and may be grown from material grossly contaminated with other organisms by culture in media containing these substances; strains ...
Hafiz, Saleem
core  

Inhibition of Streptococcus pneumoniae hyaluronidase by honeys of Malaysian origins [PDF]

, 2020
Streptococcus pneumoniae, a major human pathogen causing meningitis, pneumonia and bacteraemia produces hyaluronidase as its virulence factor. This enzyme increases the bacterial permeability to the host tissue by degrading hyaluronic acids that maintain
Mohd Nayian, Nurul Azahana, Ahmad Yusof @ Hanafi, Hanani   +1 more
core