Results 51 to 60 of about 67,369 (315)

Three‐Dimensional Ovary Model to Improve and Study Murine Follicle Growth

Advanced Healthcare Materials, EarlyView.
To develop new methods for fertility preservation in women, novel culture systems for small follicles need to be established. In this work, a poly(ethylene glycol) based scaffold, with appropriate mechanical and bioactive features to support mouse follicle and ovary cell growth is developed, and the formed cell‐follicle interactions are visualized ...
Mira Jacobs, Valon Gllareva, Lukas Moser, Silvia Pravato, Eric Mora Pimentel, Brigitte Leeners, Martin Ehrbar   +6 more
wiley   +1 more source

Hyaluronan and self-assembling peptides as building blocks to reconstruct the extracellular environment in skin tissue [PDF]

, 2013
Funding for this study was provided by the Portuguese Foundation for Science and Technology (FCT, grant PTDC/EBB-BIO/114523/2009). D. S.
Agren, Aruffo, Behanna, Burdick, Capito, Carvajal, Chow, Clark, Collier, Costa, Cui, Daley, Discher, Gajewiak, Galler, Giancotti, Hersel, Hubbell, Jiang, Jung, Khetan, Kleinman, Lauffenburger, Lin, Lowik, Mahoney, Massia, Mendes, Park, Patterson, Perlin, Picart, Pierschbacher, Ruoslahti, Sakai, Shah, Shen, Shroff, Silva, Smedsrod, Stern, Storrie, Takahashi, Wang, Webber, Webber, Yamada, Yeung, Zha, Zhang, Zhao   +50 more
core   +1 more source

Diels‐Alder Click Chemistry as a Dynamic‐Covalent Crosslinking Method in Spheroid‐Encapsulating Hydrogels for Cartilage Engineering

Advanced Healthcare Materials, EarlyView.
This research shows the development of hydrogels with Diels‐Alder click chemistry for engineering cartilage‐like tissue. The hydrogels support cartilage spheroids which could be cultured for at least 28 days. Furthermore, the spheroids showed a tendency to fuse together into a more consistent construct, and produced important components needed for ...
Sanne M. van de Looij, Antonia G. Vasilopoulou, Lennard Spauwen, Antoinette van den Dikkenberg, Jasmijn V. Korpershoek, Mylene de Ruijter, Jos Malda, Bas G. P. van Ravensteijn, Tina Vermonden   +8 more
wiley   +1 more source

TNF receptor–related factor 3 inactivation promotes the development of intrahepatic cholangiocarcinoma through NF‐κB‐inducing kinase–mediated hepatocyte transdifferentiation

Hepatology, EarlyView., 2022
Abstract Background and Aims Intrahepatic cholangiocarcinoma (ICC) is a deadly but poorly understood disease, and its treatment options are very limited. The aim of this study was to identify the molecular drivers of ICC and search for therapeutic targets.
Yuto Shiode, Takahiro Kodama, Satoshi Shigeno, Kazuhiro Murai, Satoshi Tanaka, Justin Y. Newberg, Jumpei Kondo, Shogo Kobayashi, Ryoko Yamada, Hayato Hikita, Ryotaro Sakamori, Hiroshi Suemizu, Tomohide Tatsumi, Hidetoshi Eguchi, Nancy A. Jenkins, Neal G. Copeland, Tetsuo Takehara   +16 more
wiley   +1 more source

Molecular cloning of a hyaluronidase fromBothrops pauloensisvenom gland

Journal of Venomous Animals and Toxins including Tropical Diseases, 2014
Background Hyaluronate is one of the major components of extracellular matrix from vertebrates whose breakdown is catalyzed by the enzyme hyaluronidase.
Letícia Eulalio Castanheira, Renata Santos Rodrigues, Johara Boldrini-França, Fernando PP Fonseca, Flávio Henrique-Silva, Maria I Homsi-Brandeburgo, Veridiana M Rodrigues   +6 more
doaj   +1 more source

Regenerative effects of immobilized hyaluronidase and subtilisin enzymes on experimental models of chemical and mechanical corneal trauma

Российский офтальмологический журнал, 2023
Purpose: to study the regenerative potential of immobilized hyaluronidase and subtilisin enzymes preparations in experimental models of chemical and mechanical corneal trauma.Material and methods.
V. E. Zabanova, K. I. Ershov, N. P. Leonov, A. Zh. Fursova, P. G. Madonov   +4 more
doaj   +1 more source

Ferritin‐Doped Nanoparticles Triggered Tumor‐Specific Darkening for Enhanced Photothermal Tumor Ablation and Immune Activation

Advanced Healthcare Materials, EarlyView.
Ferritin‐doped hybrid nanoparticles triggered accurate tumor‐specific hemorrhage for enhanced in situ photothermal therapy and evoked anti‐tumor immunity. Notably, HFn/GA‐Fe specifically induced tumor hemorrhage 12 h after intravenous injection, resulting in visible color darkening. Through photoacoustic imaging, tumor vessels could be clearly observed
Haidong Zha, Xiao Liang, Long Xi, Jiamao Chen, Wenzhao Zhong, Zhen Yuan, Meng Xu, Ying Zheng   +7 more
wiley   +1 more source

Nanotherapies for Atherosclerosis: Targeting, Catalysis, and Energy Transduction

Advanced Healthcare Materials, EarlyView.
Atherosclerosis management is hindered by poor drug targeting and plaque heterogeneity. Nanotechnology overcomes these barriers via three core strategies: (1) target‐engineered nanocarriers that achieve lesion‐specific precision via ligand modification, biomimetic camouflage, stimuli‐responsive release, and self‐propelling nanomotors; (2) catalytic ...
Yuqi Yang, Jingguo Qu, Tonghuan Xiao, Xinyang Han, Michael Tin‐Cheung Ying   +4 more
wiley   +1 more source

Method of hyaluronidase immobilization to produce an oral dosage form

Сибирский научный медицинский журнал
Hyaluronidase is an enzyme that helps maintain an optimal balance of hyaluronic acid in connective tissue and ensures full tissue regeneration. Currently, hyaluronidase drugs are used in various fields of medicine.
А. М. Shvetsova, К. I. Ershov, М. А. Korolev, Р. G. Madonov, L. V. Trubina   +4 more
doaj   +1 more source

Cloning and expression of the enzymatic region of Streptococcal hyaluronidase [PDF]

Iranian Journal of Basic Medical Sciences, 2014
Objective(s): Streptococcus pyogenes produces extracellular hyaluronidase enzyme. This enzyme is directly associated with the spread of the organism during infection.
Nafiseh Al-Sadat Mirjamali, Safieh Soufian, Neda Molaee, Shabnam Sadoogh Abbasian, Hamid Abtahi   +4 more
doaj