Results 41 to 50 of about 384,366 (247)

Comparison of hybrid clones derived from human breast epithelial cells and three different cancer cell lines regarding in vitro cancer stem/ initiating cell properties

BMC Cancer, 2020
Background Several physiological (fertilization, placentation, wound healing) and pathophysiological processes (infection with enveloped viruses, cancer) depend on cell fusion. In cancer it was postulated that the fusion of cancer cells with normal cells
Sera Selina Fahlbusch, Silvia Keil, Jörg T. Epplen, Kurt S. Zänker, Thomas Dittmar   +4 more
doaj   +1 more source

Impact of a senior research thesis on students' perceptions of scientific inquiry in distinct student populations

FEBS Open Bio, EarlyView.
This study addressed how a senior research thesis is perceived by undergraduate students. It assessed students' perception of research skills, epistemological beliefs, and career goals in Biochemistry (science) and BDC (science‐business) students. Completing a thesis improved confidence in research skills, resilience, scientific identity, closed gender‐
Celeste Suart, Haley L. Zubyk, Michelle Ogrodnik, Caitlin E. Mullarkey, Felicia Vulcu   +4 more
wiley   +1 more source

Hybrid Stem Cell States: Insights Into the Relationship Between Mammary Development and Breast Cancer Using Single-Cell Transcriptomics

Frontiers in Cell and Developmental Biology, 2020
Similarities between stem cells and cancer cells have implicated mammary stem cells in breast carcinogenesis. Recent evidence suggests that normal breast stem cells exist in multiple phenotypic states: epithelial, mesenchymal, and hybrid epithelial ...
Tasha Thong, Yutong Wang, Michael D. Brooks, Christopher T. Lee, Clayton Scott, Clayton Scott, Laura Balzano, Max S. Wicha, Max S. Wicha, Justin A. Colacino, Justin A. Colacino, Justin A. Colacino   +11 more
doaj   +1 more source

SmallTalk: a novel small‐sized fusion tag for peptide expression and purification

FEBS Open Bio, EarlyView.
The SmallTalk fusion tag allows for the efficient expression and purification of soluble recombinant proteins or peptides in Escherichia coli. Testing with SmallTalk‐GFP confirmed that the proteins were soluble and folded correctly, while SmallTalk‐Bin1b maintained its antimicrobial activity against various bacterial isolates. This streamlined workflow
Atika Tariq, Nestor G. Casillas‐Vega, Alma Gomez‐Loredo, Xristo Zarate   +3 more
wiley   +1 more source

Bipotential B-neutrophil progenitors are present in human and mouse bone marrow and emerge in the periphery upon stress hematopoiesis

mBio
Hematopoiesis is a tightly regulated process that gets skewed toward myelopoiesis. This restrains lymphopoiesis, but the role of lymphocytes in this process is not well defined. To unravel the intricacies of neutrophil responses in COVID-19, we performed
Shima Shahbaz, Eliana Perez Rosero, Hussain Syed, Mark Hnatiuk, Najmeh Bozorgmehr, Amirhossein Rahmati, Sameera Zia, Jason Plemel, Mohammed Osman, Shokrollah Elahi   +9 more
doaj   +1 more source

Navigating new norms: a systematic review of factors for the development of effective digital tools in higher education

FEBS Open Bio, EarlyView.
What factors make for an effective digital learning tool in Higher Education? This systematic review identifies elements of a digital tool that published examples reveal to be features of an engaging and impactful digital tool. A systematic literature search yielded 25 research papers for analysis.
Akmal Arzeman, Jessica Haines, Connie Pritchard, Stephen Rutherford, Nigel Francis   +4 more
wiley   +1 more source

Synergistic metal halide perovskite@metal-organic framework hybrids for photocatalytic CO2 reduction

iScience
Summary: The photocatalytic reduction of carbon dioxide (CO2) into multi-electron carbon products remains challenging due to the inherent stability of CO2 and slow multi-electron transfer kinetics. Here in, we synthesized a hybrid material, cesium copper
Saandra Sharma, Noah Jacob, G. Krishnamurthy Grandhi, Mahendra B. Choudhary, Swathi Ippili, Venkatesha R. Hathwar, Paola Vivo, Rabindranath Lo, M. Motapothula, Kolleboyina Jayaramulu   +9 more
doaj   +1 more source

Hybrid cells derived from breast epithelial cell/breast cancer cell fusion events show a differential RAF-AKT crosstalk

Cell Communication and Signaling, 2012
Background The biological phenomenon of cell fusion has been linked to several characteristics of tumour progression, including an enhanced metastatogenic capacity and an enhanced drug resistance of hybrid cells. We demonstrated recently that M13SV1-EGFP-
Özel Cem, Seidel Jeanette, Meyer-Staeckling Sönke, Brandt Burkhard H, Niggemann Bernd, Zänker Kurt S, Dittmar Thomas   +6 more
doaj   +1 more source

Kaposi's sarcoma-associated herpesvirus vFLIP promotes MEndT to generate hybrid M/E state for tumorigenesis.

PLoS Pathogens, 2021
Kaposi's sarcoma (KS) is an angioproliferative and invasive tumor caused by Kaposi's sarcoma-associated herpesvirus (KSHV). The cellular origin of KS tumor cells remains contentious.
Weikang Chen, Yao Ding, Dawei Liu, Zhengzhou Lu, Yan Wang, Yan Yuan   +5 more
doaj   +1 more source

Analysis of Treacher Collins syndrome 4‐associated mutations in Schizosaccharomyces pombe

FEBS Open Bio, EarlyView.
Fission yeast models carrying Treacher Collins syndrome type 4‐associated mutations reveal that impaired processivity of RNA polymerase I leads to defective rRNA transcription. This study highlights the essential role of a conserved arginine residue in Pol I elongation and provides mechanistic insight into the pathogenesis of ribosomopathies.
Kei Kawakami, Hiroaki Kato
wiley   +1 more source