Results 41 to 50 of about 524,580 (264)

Challenges and Solutions of Applying Large-Scale Agile at Organization-al Level [PDF]

open access: yesInformatică economică, 2019
Large-scale agile development receives widespread interest today in research and practice. Two different dimensions could be considered in the context of applying agile at large-scale: individual level, like project or team, and organization level.
Florin DUMITRIU   +2 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

open access: yesMolecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano   +6 more
wiley   +1 more source

Seepage Analysis in Short Embankments Using Developing a Metaheuristic Method Based on Governing Equations

open access: yesApplied Sciences, 2020
Seepage is one of the most challenging issues in some procedures such as design, construction, and operation of embankment or earth fill dams. The purpose of this research is to develop a new solution based on governing equations to solve the seepage ...
Dongchun Tang   +6 more
doaj   +1 more source

Hybrid method of tolerance design [PDF]

open access: yesICECS'99. Proceedings of ICECS '99. 6th IEEE International Conference on Electronics, Circuits and Systems (Cat. No.99EX357), 2003
A new method of tolerance design, which we call the hybrid method that accelerates the attainment of optimal design center, is proposed. The method combines geometry search with statistical process. At the start of the process, the region of acceptability is estimated using boundary search method, A new tolerance region that covers much of the ...
Foo, Say Wei, Lin, Yu
openaire   +2 more sources

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Assessment of the Long-Term High-Spatial-Resolution Global LAnd Surface Satellite (GLASS) Surface Longwave Radiation Product Using Ground Measurements

open access: yesIEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing, 2020
In this article, we comprehensively assessed the newly released long-term high-spatial-resolution Global LAnd Surface Satellite (GLASS) surface longwave (LW) radiation product using site measurements of LW fluxes. In total, three years of ground-measured
Qi Zeng, Jie Cheng, Lixin Dong
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

Hybrid Method for Full-Wave Simulations of Forests at L-Band

open access: yesIEEE Access, 2022
The full-wave simulations of 3D Maxwell equations of forests at L-band are carried out with a two-step hybrid method. The tallest trees considered include one 8-meter tall trunk, 18 primary branches and 108 secondary branches.
Weihui Gu   +3 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

open access: yesMolecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober   +16 more
wiley   +1 more source

IMPACT OF PANELISTS ON WIBOR RATES – HYBRID APPROACH

open access: yesPolityki Europejskie, Finanse i Marketing, 2020
The reform of financial benchmarks is one of the key elements of stability and trust in the financial market. In the money market, it is difficult to implement reforms because of the disappearance of the interbank deposit market, which was a reference ...
Piotr Mielus
doaj   +1 more source

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