Results 81 to 90 of about 530,036 (269)

A hybrid approach for pattern recognition and interpretation in age-related false memory

Frontiers in Psychology
IntroductionAging is associated with a decline in essential cognitive functions such as language processing, memory, and attention, which significantly impacts the quality of life in later years.
Noorbakhsh Amiri Golilarz, Elias Hossain, Shahram Rahimi, Hossein Karimi   +3 more
doaj   +1 more source

Purification and preparation of Marchantia polymorpha Auxin Response Factor 2 for phase separation studies

FEBS Open Bio, EarlyView.
We describe detailed protocols for the purification and preparation of Marchantia polymorpha Auxin Response Factor 2 (MpARF2). This protein is fused to an MBP solubility tag and an mNG fluorescent tag and is purified from Escherichia coli. The presented procedures make it possible to study MpARF2 assemblies, which could arise from phase separation ...
Bas Janssen, Robin Romein, Willy A. M. van den Berg, Simon Lindhoud, Jan Willem Borst, Carlo P. M. van Mierlo   +5 more
wiley   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

A Hybrid VMD-SSA-LSTM Framework for Short-Term Wind Speed Prediction Based on Wind Farm Measurement Data

Energies
Aiming at the nonlinear and non-stationary characteristics of wind speed series, this study proposes a hybrid forecasting framework that integrates Variational Mode Decomposition (VMD), Sparrow Search Algorithm (SSA), and Long Short-Term Memory (LSTM ...
Ruisheng Feng, Bin Fu, Hanxi Xiao, Xu Wang, Maoyu Zhang, Shuqin Zheng, Yanru Wang, Tingjun Xu, Lei Zhou   +8 more
doaj   +1 more source

Understanding the Effect of Statins and Patient Adherence in Atherosclerosis via a Quantitative Systems Pharmacology Model Using a Novel, Hybrid, and Multi-Scale Approach

Frontiers in Pharmacology, 2017
Background and Objective: Statins are one of the most prescribed drugs to treat atherosclerosis. They inhibit the hepatic HMG-CoA reductase, causing a reduction of circulating cholesterol and LDL levels.
Cesar Pichardo-Almarza, Cesar Pichardo-Almarza, Vanessa Diaz-Zuccarini, Vanessa Diaz-Zuccarini   +3 more
doaj   +1 more source

Using cell‐free RNA to identify B‐ and T‐cell clonality for diagnosis and monitoring of B‐ and T‐cell neoplasms

FEBS Open Bio, EarlyView.
Using peripheral blood for determining B‐cell or T‐cell clonality is more reliable when we use cell‐free RNA (cfRNA) because cells release blood significantly more RNA than DNA. Next‐generation sequencing (NGS) of cfRNA allows us to evaluate fragment cfRNA and evaluate clonality reliably without the need for prior determination of the specific dominant
Adam Albitar, Sally Agersborg, Ahmed Charifa, Pooja Phull, Noa Biran, David Vesole, Harsh Parmar, Andrew Pecora, Andrew Ip, Andre Goy, David Siegel, Maher Albitar   +11 more
wiley   +1 more source

Exploratory Study on Hybrid Systems Performance: A First Approach to Hybrid ML Models in Breast Cancer Classification

AI
The classification of breast cancer using machine learning techniques has become a critical tool in modern medical diagnostics. This study analyzes the performance of hybrid models that combine traditional machine learning algorithms (TMLAs) with a ...
Francisco J. Rojas-Pérez, José R. Conde-Sánchez, Alejandra Morlett-Paredes, Fernando Moreno-Barbosa, Julio C. Ramos-Fernández, José Luna-Muñoz, Genaro Vargas-Hernández, Blanca E. Jaramillo-Loranca, Juan M. Xicotencatl-Pérez, Eucario G. Pérez-Pérez   +9 more
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Self‐Regulated Learning Meets AI: Reinterpreting Self‐Regulation, Co‐Regulation, and Socially Shared Regulation in Human–AI Interaction

New Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Advancing artificial intelligence (AI) has transformed learning and work, yet higher education and professional development programs have not systematically equipped learners for AI‐prevalent environments. This lack of preparation creates uncertainty regarding control, responsibility, trust, and accountability.
Moon‐Heum Cho, Jerusalem Merkebu
wiley   +1 more source

Sex Representation in US Stroke Clinical Trials: A Decade of Trends and Challenges

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Stroke remains a major cause of disability and mortality in the US, with significant sex‐based disparities, and females remain underrepresented in stroke clinical trials. We aimed to examine sex representation in US‐based stroke clinical trials, identify trial characteristics associated with higher female enrollment (≥ 50%), and ...
Chaitali Dagli, Mudasir Andrabi, Tova Cohen, Pranali G. Patel, Tapasya Katta, Chen Lin   +5 more
wiley   +1 more source