Results 71 to 80 of about 530,036 (269)

Digital Twin-Based Virtual Sensor Data Prediction and Visualization Techniques for Smart Swine Barns

Sensors
To address the limitations of sensor deployment and high maintenance costs in smart swine barns, this study proposes a digital twin (DT)-based virtual sensor prediction and visualization method. Spatial constraints and harsh barn environments often cause
Hyeon-O Choe, Meong-Hun Lee
doaj   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Advancing Nutritional Status Classification With Hybrid Artificial Intelligence: A Novel Methodological Approach

Brain and Behavior
Purpose Malnutrition remains a critical public health issue in low‐income countries, significantly hindering economic development and contributing to over 50% of infant deaths.
Md. Moddassir Alam, Asif Irshad Khan, Aasim Zafar, Mohammad Sohail, Mohammad Tauheed Ahmad, Rezaul Azim   +5 more
doaj   +1 more source

UAS-Guided Analysis of Electric and Magnetic Field Distribution in High-Voltage Transmission Lines (Tx) and Multi-Stage Hybrid Machine Learning Models for Battery Drain Estimation

IEEE Access
Unmanned aerial systems/vehicles (UAS/UAVs) are increasingly utilized for inspecting high-voltage (HV) Tx lines. Operating on batteries, these UAVs are equipped with various electrical sensors, microprocessors, and motors.
Tanzim Jim Hassan, Jamison Jangula, Akshay Ram Ramchandra, Niroop Sugunaraj, Barathwaja Subash Chandar, Prashanth Rajagopalan, Farishta Rahman, Prakash Ranganathan, Ryan Adams   +8 more
doaj   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

A hybrid analytical model for thermodynamic calculations of supercritical carbon dioxide centrifugal compressors

Journal of Thermal Science and Technology
Thermodynamic calculations are important procedures for preliminary design or performances assessment of supercritical carbon dioxide (SCO2) centrifugal compressors. However, the thermodynamic calculations are usually based on the discrete database (NIST
Xiaojian LI, Chenshuo XU, Yijia ZHAO, Ming ZHAO, Zhengxian LIU   +4 more
doaj   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

A Novel Hybrid Deep Learning-Based Framework for Intelligent Anomaly Detection in Smart Meters

IEEE Access
Smart meters deployment in residential buildings generates a large volume of time-series data that offers valuable insights about electricity consumption.
Simarjit Kaur, Priyansh Chowhan, Aashima Sharma   +2 more
doaj   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source