Results 71 to 80 of about 2,216,664 (298)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Robot fault prediction based on improved GM(1,1) model and RBF

Frontiers in Mechanical Engineering
IntroductionAs the core equipment of intelligent manufacturing, the operational stability of industrial robots directly affects production efficiency and safety.
Liang Chen
doaj   +1 more source

Adaptive Feature Extractor of Global Representation and Local Semantics for Text Classification

IEEE Access, 2020
A hybrid model of Convolutional Neural Network (CNN) and self-attention has achieved remarkable results in text classification fields. In previous researches, text local semantics(captured by CNN) and global representation (extracted by self-attention ...
Chaofan Wang, Shenggen Ju, Yuezhong Liu, Run Chen, Xiaoming Huang   +4 more
doaj   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Cervical cancer classification using a novel hybrid approach

Frontiers in Oncology
ObjectiveCervical cancer is among the most frequently diagnosed malignancies in women. It is the fourth most prevalent malignancy in women worldwide. Pap smear tests, a popular and effective medical procedure, enable the early detection and screening of ...
Jheelam Mondal, Rajdeep Chatterjee, Mahendra Kumar Gourisaria, Manoj Sahni, Ernesto León-Castro   +4 more
doaj   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

Integrative Deep Learning Architecture for High-Accuracy Medical Image Segmentation: Combining U-Net, ResNet, and Transformers

Journal of Technology Informatics and Engineering
Medical image segmentation plays a vital role in diagnosis and treatment planning by extracting clinically relevant information from imaging data. Conventional methods often struggle with variations in anatomical structure and imaging quality, leading to
Devi Zakiyatus Sholekhah, Dian Noviar
doaj   +1 more source

An Improved Stock Price Prediction using Hybrid Market Indicators [PDF]

, 2012
In this paper the effect of hybrid market indicators is examined for an improved stock price prediction. The hybrid market indicators consist of technical, fundamental and expert opinion variables as input to artificial neural networks model.
Adebiyi, A. A., Adebiyi, Marion O., Ayo, C. K., Otokiti, S. O.   +3 more
core   +1 more source

Safe Neighborhood Computation for Hybrid System Verification

, 2015
For the design and implementation of engineering systems, performing model-based analysis can disclose potential safety issues at an early stage. The analysis of hybrid system models is in general difficult due to the intrinsic complexity of hybrid ...
Deng, Yi, Julius, Agung
core   +2 more sources

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

FEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde, Unai Alduntzin, Gorka Prieto, Ugo Mayor   +3 more
wiley   +1 more source