Results 51 to 60 of about 530,036 (269)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Robot fault prediction based on improved GM(1,1) model and RBF

Frontiers in Mechanical Engineering
IntroductionAs the core equipment of intelligent manufacturing, the operational stability of industrial robots directly affects production efficiency and safety.
Liang Chen
doaj   +1 more source

Adaptive Feature Extractor of Global Representation and Local Semantics for Text Classification

IEEE Access, 2020
A hybrid model of Convolutional Neural Network (CNN) and self-attention has achieved remarkable results in text classification fields. In previous researches, text local semantics(captured by CNN) and global representation (extracted by self-attention ...
Chaofan Wang, Shenggen Ju, Yuezhong Liu, Run Chen, Xiaoming Huang   +4 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Cervical cancer classification using a novel hybrid approach

Frontiers in Oncology
ObjectiveCervical cancer is among the most frequently diagnosed malignancies in women. It is the fourth most prevalent malignancy in women worldwide. Pap smear tests, a popular and effective medical procedure, enable the early detection and screening of ...
Jheelam Mondal, Rajdeep Chatterjee, Mahendra Kumar Gourisaria, Manoj Sahni, Ernesto León-Castro   +4 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Integrative Deep Learning Architecture for High-Accuracy Medical Image Segmentation: Combining U-Net, ResNet, and Transformers

Journal of Technology Informatics and Engineering
Medical image segmentation plays a vital role in diagnosis and treatment planning by extracting clinically relevant information from imaging data. Conventional methods often struggle with variations in anatomical structure and imaging quality, leading to
Devi Zakiyatus Sholekhah, Dian Noviar
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Hierarchical Local-Global Feature Fusion Network for Robust Ship Target Recognition in Complex Maritime Environment

Sensors
Accurate ship target recognition remains challenging in complex maritime environments due to background clutter, multiscale target appearance, and limited discriminative features extracted by single-type networks.
Xuanhe Liu, Shuning Zhang, Si Chen, Jianchao Li, Yingying Luo   +4 more
doaj   +1 more source