Results 61 to 70 of about 244,152 (257)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

open access: yesMolecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober   +16 more
wiley   +1 more source

On complex hybrid numbers: Algebraic structures, matrix representations, and geometric interpretations

open access: yesKuwait Journal of Science
This work introduces complex hybrid numbers, an extension of hybrid numbers, which are defined as Z = z0 + z1i + z2ɛ + z3ℎ where zi are complex numbers and iℎ = −ℎi = i + ɛ.
Furkan Seçgin   +2 more
doaj   +1 more source

Differentiation of mouse embryonic stem cells and their hybrids during embryoid body formation

open access: yesGenetics and Molecular Biology, 2002
We studied the karyotypes of three hybrid clones of mouse embryonic stem cells and murine splenocytes (two having near diploid and one having near tetraploid chromosome numbers) and the characteristics of their differentiation during the formation of ...
Josane Mittmann   +5 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

Solid-Fuel Regression Rate for Standard-Flow Hybrid Rocket Motors

open access: yesJournal of Thermal Science and Technology, 2012
Marxman's diffusion-limited analysis of hybrid rocket combustion has been often used to investigate various combustion problems in hybrid rocket motors.
Takakazu MORITA   +3 more
doaj   +1 more source

Thermodynamic simulation of a wind turbine-fuel cell hybrid system with application in a distributed generation system [PDF]

open access: yesمجله مدل سازی در مهندسی, 2018
The aim of this article is to design wind turbine PEM (polymer electrolyte membrane) fuel cell hybrid system in standalone area for Tehran, Mashhad, Manjil, and Zabol.
جاماسب پیرکندی, Reza Harbi
doaj   +1 more source

A Study on Horadam Hybrid Numbers

open access: yesTURKISH JOURNAL OF MATHEMATICS, 2020
In this paper, we study Horadam hybrid numbers. For these numbers, we give the exponential generating function, Poisson generating function, generating matrix, Vajda's, Catalan's, Cassini's, and d'Ocagne's identities. In addition, we offer Honsberger formula, general bilinear formula, and some summation formulas for these numbers.
Tuncay Deniz ŞENTÜRK   +3 more
openaire   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

open access: yesMolecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Phenotypic Correlation and Path Coefficient and Relative Importance Studies in Okra Abelmoschus esculentus (L.) Moench.

open access: yesMaǧallaẗ al-baṣraẗ al-ʻulūm al-zirāʻiyyaẗ, 2023
The experiment was undertaken to study correlation and path coefficient and relatively importance to yield and its components traits in Okra. The experimental material consisted of six generations (P1, P2, F1, F2, BC1 and BC2) through two crosses, which ...
Reham A. Nbeaa   +2 more
doaj   +4 more sources

The Integrated Genomic Architecture and Evolution of Dental Divergence in East African Cichlid Fishes (Haplochromis chilotes x H. nyererei)

open access: yesG3: Genes, Genomes, Genetics, 2017
The independent evolution of the two toothed jaws of cichlid fishes is thought to have promoted their unparalleled ecological divergence and species richness.
C. Darrin Hulsey   +5 more
doaj   +1 more source

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