Results 61 to 70 of about 242,971 (256)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

A Note on Generalized k-Order F&L Hybrinomials

Axioms
In this study, we introduce generalized k-order Fibonacci and Lucas (F&L) polynomials that allow the derivation of well-known polynomial and integer sequences such as the sequences of k-order Pell polynomials, k-order Jacobsthal polynomials and k-order ...
Süleyman Aydınyüz, Gül Karadeniz Gözeri   +1 more
doaj   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Hybrid numbers with balancing and Lucas balancing hybrid number coefficients

Communications Faculty of Sciences University of Ankara Series A1 Mathematics and Statistics
In this note, we made a connection between hybrid numbers and hybrid balancing, and hybrid Lucas balancing number. Initially, we obtained for these new number recurrence relation, some important relations among new numbers, and Binet's like formula.
Murat Turan, Sıddıka Özkaldı Karakuş   +1 more
openaire   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Hybrid numbers with the view of multiplicative calculus

Kuwait Journal of Science
This paper defines a new number system called multiplicative hybrid numbers. A multiplicative hybrid number is one that satisfies the non-commutative multiplication criteria using any combination of multiplicative complex (𝑖 2⋆ ⋆ = −⋆1⋆ ), multiplicative
Umut Selvi, Derya Sağlam, Emel Karaca
doaj   +1 more source

A hybrid random number generator(HRNG)

Revista de Matemática: Teoría y Aplicaciones, 2011
The purpose of this paper is to present a novel Hybrid Random Number Generator (HRNG). Here “hybrid” refers to the fact that to construct this generator it is necessary to use 1)physical components – texts – and a physical process, and 2) a mathematical procedure. This HRNG makes it possible to generate genuine random numbers which may be used both for
Skliar, Osvaldo, Monge, Ricardo E., Medina, Víctor, Gapper, Sherry, Oviedo, Guillermo   +4 more
openaire   +4 more sources

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source