Results 71 to 80 of about 1,050,112 (246)

NKCC1: A key regulator of glioblastoma progression

open access: yesMolecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen   +5 more
wiley   +1 more source

Phenotypic Correlation and Path Coefficient and Relative Importance Studies in Okra Abelmoschus esculentus (L.) Moench.

open access: yesMaǧallaẗ al-baṣraẗ al-ʻulūm al-zirāʻiyyaẗ, 2023
The experiment was undertaken to study correlation and path coefficient and relatively importance to yield and its components traits in Okra. The experimental material consisted of six generations (P1, P2, F1, F2, BC1 and BC2) through two crosses, which ...
Reham A. Nbeaa   +2 more
doaj   +4 more sources

The Integrated Genomic Architecture and Evolution of Dental Divergence in East African Cichlid Fishes (Haplochromis chilotes x H. nyererei)

open access: yesG3: Genes, Genomes, Genetics, 2017
The independent evolution of the two toothed jaws of cichlid fishes is thought to have promoted their unparalleled ecological divergence and species richness.
C. Darrin Hulsey   +5 more
doaj   +1 more source

Two-stage hybrid algorithm for recognition of industrial slab numbers with data quality improvement

open access: yesComplex & Intelligent Systems, 2022
As the unique recognition of each slab, the accurate recognition of slab number is especially critical for the hot rolling production process. However, the collected data are often of low quality due to poor production environment conditions, making ...
Qingqing Liu   +2 more
doaj   +1 more source

Effect of strong wakes on waves in two-dimensional plasma crystals

open access: yes, 2013
We study effects of the particle-wake interactions on the dispersion and polarization of dust lattice wave modes in two-dimensional plasma crystals. Most notably, the wake-induced coupling between the modes causes the branches to "attract" each other ...
Ivlev, Alexei   +3 more
core   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

open access: yesMolecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary   +1 more
wiley   +1 more source

Ion acceleration in non-relativistic astrophysical shocks

open access: yes, 2011
We explore the physics of shock evolution and particle acceleration in non-relativistic collisionless shocks using multidimensional hybrid simulations.
Gargaté, L., Spitkovsky, A.
core   +1 more source

Down‐regulation of Shh in the hair follicles of mice during chemotherapy‐induced hair loss is mediated by the JAK/STAT1 signaling pathway

open access: yesFEBS Open Bio, EarlyView.
We found that during chemotherapy‐induced alopecia (CIA), Sonic hedgehog (Shh) expression significantly decreased in hair follicle Shh+ cells, whereas the Janus‐activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) signaling pathway was markedly activated.
Ruifang Fan   +6 more
wiley   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

open access: yesFEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon   +6 more
wiley   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

open access: yesFEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold   +11 more
wiley   +1 more source

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