Results 41 to 50 of about 1,381,095 (238)

Hybrid male sterility in the house mouse [PDF]

, 2016
Hybrid sterility is one of the postzygotic reproductive barriers that can prevent gene flow between diverging populations. Identification of sterility genes and their function is consequently demanded for understanding of processes that can ultimately ...
Mrkvicová, Martina
core  

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Unraveling Advances in Rice Male Sterility Systems: From Genetic Basis to Hybrid Breeding Innovation

Plants
Heterosis is a landmark innovation in modern agriculture, which has been widely exploited to boost crop productivity. As a staple food for over half of the global population, rice depends heavily on heterosis for yield improvement.
Wei Liu, Jinlong Ni, Changkai Ma, Jianbo Yang, Shimei Wang, Deze Xu   +5 more
doaj   +1 more source

Hybrid Sterility Locus on Chromosome X Controls Meiotic Recombination Rate in Mouse. [PDF]

PLoS Genetics, 2016
Meiotic recombination safeguards proper segregation of homologous chromosomes into gametes, affects genetic variation within species, and contributes to meiotic chromosome recognition, pairing and synapsis.
Maria Balcova, Barbora Faltusova, Vaclav Gergelits, Tanmoy Bhattacharyya, Ondrej Mihola, Zdenek Trachtulec, Corinna Knopf, Vladana Fotopulosova, Irena Chvatalova, Sona Gregorova, Jiri Forejt   +10 more
doaj   +1 more source

Purification and preparation of Marchantia polymorpha Auxin Response Factor 2 for phase separation studies

FEBS Open Bio, EarlyView.
We describe detailed protocols for the purification and preparation of Marchantia polymorpha Auxin Response Factor 2 (MpARF2). This protein is fused to an MBP solubility tag and an mNG fluorescent tag and is purified from Escherichia coli. The presented procedures make it possible to study MpARF2 assemblies, which could arise from phase separation ...
Bas Janssen, Robin Romein, Willy A. M. van den Berg, Simon Lindhoud, Jan Willem Borst, Carlo P. M. van Mierlo   +5 more
wiley   +1 more source

Genomic architecture and molecular mechanisms of hybrid sterility in mice. [PDF]

, 2021
Hybrid sterility is one of the reproductive isolation mechanisms restricting gene flow between the related species and leading to speciation. PR domain containing 9 (Prdm9), the only known vertebrate hybrid sterility gene, determines the sites of ...
Vališková, Barbora
core   +1 more source

The C‐terminal domain of yeast Arginyltransferase1 is essential for its catalytic activity

FEBS Open Bio, EarlyView.
Arginyltransferase 1 (Ate1), a eukaryotic enzyme, catalyses arginylation, transferring arginine from tRNA‐Arg to the amino terminus of the target protein. Overexpression of Ate1 in yeast is lethal and is dependent on arginylation. This study elucidates how mutations in the cofactor‐binding and active site of Ate1 and truncation of its structural ...
Vikas Kumar Yadav, Shweta Shweta, Manisha Malhotra, Vikash Maurya, Akhilesh Kumar   +4 more
wiley   +1 more source

Advances in plant male sterility for hybrid seed production: an overview of conditional nuclear male sterile lines and biotechnology-based male sterile systems

Frontiers in Plant Science
Male sterility forms the foundation of hybrid seed production technology in field crops. A variety of genetically controlled male sterility/fertility systems starting with cytoplasmic male sterility (CMS), genic male sterility (GMS) including conditional
Naresh Vasupalli, Naresh Vasupalli, Kanakachari Mogilicherla, Kanakachari Mogilicherla, Vahab Shaik, Vahab Shaik, K. R. S. Sambasiva Rao, Shripad R. Bhat, Xinchun Lin, Xinchun Lin   +9 more
doaj   +1 more source

3D‐Printed Titanium Gyroid Scaffold Structure Integrated With Tough Hybrid Materials for Cartilage Replacement

Advanced Engineering Materials, EarlyView.
This study proposes a potential device design for joint cartilage replacement. Silica‐polytetrahydrofuran (SiO2‐PolyTHF) hybrids with customizable mechanical properties were developed to mimic the characteristics of a natural meniscus. These were synthesized through a two‐pot sol–gel hybrid process.
Yu‐Chien Lin, Gloria R. Young, Francesca Tallia, Reece N. Oosterbeek, Shaaz Ghouse, Edward Spiers, Nupur Kohli, Tom Briggs, Marc Masen, Siwei Li, Ren‐Jei Chung, Jonathan R. T. Jeffers, Julian R. Jones   +12 more
wiley   +1 more source