Results 11 to 20 of about 2,558 (239)
, 2022 In recent years, spirocycles have been the focus of medicinal chemistry, and several drugs or drug candidates incorporating these “non-planar” chemical motifs have been developed.
Yann, Foricher +4 more
core +1 more source
, 2016 A straightforward and facile method has been developed to prepare 1,1-disubstituted hydrazines via Lewis base promoted direct reductive hydrazination. Under the catalysis of hexamethylphosphoramide (HMPA) and N,N-dimethylacetamide (DMAc), respectively ...
Di, X +5 more
core +2 more sources
2-tert-Butyl-5,6,7,8,9,10-hexahydrocyclohepta[b]indole
Molbank, 2011 2-tert-Butyl-5,6,7,8,9,10-hexahydrocyclohepta[b]indole was synthesized by reaction of cycloheptanone and (4-tert-butylphenyl)hydrazine hydrochloride in the presence of sodium acetate and sulfuric acid in glacial acetic acid via Fischer indole synthesis.
Janina Wobbe +5 more
doaj +1 more source
Synthesis of the Fmoc-aza-Arg(Boc)2 precursor via hydrazine alkylation; pp. 438–443 [PDF]
Proceedings of the Estonian Academy of Sciences, 2014 The aza-arginine precursor Fmoc-aza-Arg(Boc)2 was synthesized starting from mono-protected hydrazines via an aza-ornithine precursor. This reaction path is shorter and more efficient than the reductive alkylation reaction.
Anton Mastitski +2 more
doaj +1 more source
Synthesis of N-CF3 hydrazines through radical trifluoromethylation of azodicarboxylates
, 2021 International audienceNovel family of N -CF 3 hydrazines have been prepared from a direct way involving the available and cheap Langlois ...
Crousse, Benoît +3 more
core +1 more source
Ultrasonics Promoted Synthesis of 5-(Pyrazol-4-yl)-4,5-Dihydropyrazoles Derivatives
Applied Sciences, 2013 A series of new 1,3-diaryl-5-(1-phenyl-3-methyl-5-chloropyrazol-4-yl)-4,5-dihydropyrazole derivatives have been synthesized under sonication conditions in ethanol or methanol/glacial acetic acid mixture (5/1 ratio) with two equivalents of hydrazines and ...
Manuel Nogueras +4 more
doaj +1 more source
Conception et synthèse de nouvelles hydrazines fluorées
, 2022 Thanks to particular Physico-chemical properties, fluorine is becoming increasingly important in medicinal chemistry. Hydrazines are essential for synthesising N-heterocyclic functionalised compounds and for their many applications in many areas of ...
Cao, Tingting
core +1 more source
, 2016 Rhodium-catalyzed addition–cyclization of hydrazines with alkynes has been achieved to afford highly substituted pyrazoles under mild conditions. The cascade reaction involves two transformations: addition of the C–N bond of hydrazines to alkynes via ...
Xiao Feng Mao (1784368) +4 more
core +3 more sources
Synthesis of certain nitropyridine derivatives bearing 2-thiazolyl hydrazines with expected monoamine oxidase inhibitory activity [PDF]
Bulletin of Pharmaceutical Sciences. Assiut University, 1999 Two series of nitropyridine derivs. bearing 2-thiazolyl hydrazines were synthesized and evaluated for their monoamine oxidase (MAO) inhibitory activity by in vitro tests to assay their effect on rat liver mitochondria by a kynuramine fluorimetric assay.
Hoda Hassan
doaj +1 more source
Molecules, 2021 Nitroalkanes activated with polyphosphoric acid could serve as efficient electrophiles in reactions with amines and hydrazines, enabling various cascade transformations toward heterocyclic systems.
Alexander V. Aksenov +6 more
doaj +1 more source