Copper-catalysed enantioconvergent N-alkylation of hydrazines with racemic α-haloamides to access enantioenriched hydrazines [PDF]
Nature CommunicationsChiral hydrazines are important building blocks in chiral drug molecules, N-amino peptides, and aza-heterocycles. The catalytic enantioconvergent N-alkylation of readily available hydrazine derivatives with various racemic alkyl halides offers a highly ...
Nan Li +6 more
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Reaction of Nitrilimines and Nitrile Oxides with Hydrazines, Hydrazones and Oximes
Molecules, 2005 This review article discusses the reaction of nitrilimines and nitrile oxides with hydrazines, hydrazones, and oximes. Three reaction modes were observed.
Adel M Awadallah
exaly +3 more sources
Trifluoroethanol-assisted asymmetric propargylic hydrazination to α-tertiary ethynylhydrazines enabled by sterically confined pyridinebisoxazolines [PDF]
Nature CommunicationsWe report the highly enantioselective Cu-catalyzed asymmetric propargylic substitution (APS) of α-tertiary propargylic electrophiles using hydrazines and hydroxylamines as a fruitful strategy to access multifunctional α-tertiary hydrazines or ...
Yi Gong +10 more
doaj +2 more sources
Chemoselective synthesis of 1,3,4-thiadiazoles from acyl hydrazines and nitroalkanes using elemental sulfur [PDF]
Nature CommunicationsSubstituted 1,3,4-thiadiazoles find extensive use in pharmaceutical, agricultural, and materials chemistry. The incorporation of adaptable heterocyclic pharmacophores results in tunable hybrid molecules with diverse medicinal properties.
Xiaonan Wang +6 more
doaj +2 more sources
Direct Cyclization/Chlorination Strategy of Hydrazines for Synthesis of 4-Chloropyrazoles by TCCA [PDF]
MoleculesA new method for synthesis of various 4-chloropyrazoles through the direct cyclization/chlorination of hydrazines by using 1,3,5-trichloroisocyanuric acid (TCCA) as both oxidant and chlorinating agent under mild conditions has been proposed. Based on the
Qingfu Deng +3 more
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The synthesis and properties of some hydrazines [PDF]
A new synthetic method, applicable to the preparation of a wide range of hydrazine derivatives, is described. This involves the diborane reduction of a hydrazone, or, more conveniently, the reductive-condensation of a hydrazine and the appropriate ...
Gardner, R.J.
core +8 more sources
Advances in the Different Synthetic Routes of Fluorinated Hydrazines. [PDF]
Chem RecInternational audienceHydrazine derivatives are widely used in various research fields, including pharmaceuticals, agrochemicals, polymers, and industrial dyes, as well as serving as precursors in organic synthesis.
Kyrko D, Crousse B.
europepmc +2 more sources
Synthetic methodology for alkyl substituted hydrazines
, 2001 Substituted hydrazines have found many technical and commercial applications and this is reflected in the immense number of such compounds synthesized to date.
Ragnarsson, U,
core +9 more sources
Molecules, 2022 In silico evaluation of various regioisomeric 5- and 3-hydroxy-substituted alkyl 1-aryl-1H-pyrazole-4-carboxylates and their acyclic precursors yielded promising results with respect to their binding in the active site of dihydroorotate dehydrogenase of ...
Luka Vah +8 more
doaj +1 more source
Synthesis and Characterization of Novel Methyl (3)5-(N-Boc-piperidinyl)-1H-pyrazole-4-carboxylates
Molecules, 2021 Series of methyl 3- and 5-(N-Boc-piperidinyl)-1H-pyrazole-4-carboxylates were developed and regioselectively synthesized as novel heterocyclic amino acids in their N-Boc protected ester form for achiral and chiral building blocks.
Gita Matulevičiūtė +9 more
doaj +1 more source