Synthesis, biological evaluation and SAR study of novel pyrazole analogues as inhibitors of Mycobacterium tuberculosis [PDF]
, 2008 As a continuation of our previous work that turned toward the identification of antimycobacterial compounds with innovative structures, two series of pyrazole derivatives were synthesized by parallel solution-phase synthesis and were assayed as ...
Ahmad +27 more
core +1 more source
Molecules, 2021 Nitroalkanes activated with polyphosphoric acid could serve as efficient electrophiles in reactions with amines and hydrazines, enabling various cascade transformations toward heterocyclic systems.
Alexander V. Aksenov +6 more
doaj +1 more source
Key Intermediates: A simple and Highly Selective Synthesis of 5-amino-1-aryl-1H-pyrazole-4-carbonitriles for Applications in the Crop Protection [PDF]
, 2015 A series of six pyrazoles was synthesized by Michael-type addition reaction. The molecules 5- amino-1-aryl-1H-pyrazole-4-carbonitrile (3a-f) were synthesized from (ethoxymethylene)malononitrile (1) and fluorinated and non-fluorinated aryl hydrazines (2a ...
Murguia, Marcelo Cesar +2 more
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Results in Chemistry, 2021 An efficient tetra-n-butyl ammonium peroxydisulphate (TBA)2S2O8 catalyzed a direct one-pot synthesis of fully substituted pyrazoles in excellent yields with high regioselectivity has been described via a three-component cyclocondensation of aldehydes ...
Mallesh Magini +5 more
doaj +1 more source
First Principles Study of the Ignition Mechanism for Hypergolic Bipropellants: N,N,N′,N′-Tetramethylethylenediamine (TMEDA) and N,N,N′,N′-Tetramethylmethylenediamine (TMMDA) with Nitric Acid [PDF]
, 2011 We report quantum mechanics calculations (B3LYP flavor of density functional theory) to determine the chemical reaction mechanism underlying the hypergolic reaction of pure HNO_3 with N,N,N′,N′-tetramethylethylenediamine (TMEDA) and N,N,N′,N ...
Dasgupta, Siddharth +3 more
core +2 more sources
Synthesis and reactions of 1-amino-1,5,6,10b-tetrahydroimidazo[2,1-a]isoquinolin-2(3H)-ones [PDF]
, 2008 1-Amino-1,5,6,10b-tetrahydroimidazo[2,1-a]isoquinolin-2(3H)-ones, as previously unknown ring-annelated isoquinolines with a 3-aminoimidazolidin-4-one scaffold, were selectively prepared upon reacting 2-carbamoylmethyl- or 2-ethoxycarbonylmethyl-3,4 ...
De Kimpe, Norbert +5 more
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1,1,2,2-Tetrakis[(benzoylamino)methyl]hydrazine
Molbank, 2011 We report herein the synthesis of 1,1,2,2-tetrakis[(benzoylamino)methyl]-hydrazine from (benzamidomethyl)triethylammonium chloride and hydrazine monohydrate in the presence of triethylamine in ethanol/aqueous media. The structure of the newly synthesized
Emil Popovski +2 more
doaj +1 more source
One-pot preparation of carbamoyl benzotriazoles and their applications in the preparation of ureas, hydrazinecarboxamides and carbamic esters [PDF]
Journal of the Serbian Chemical Society, 2016 Carbamoyl benzotriazoles were conveniently synthesized in one-pot from carboxylic acids, diphenylphosphorazidate (DPPA) and benzotriazole (BtH). The reactivity and applications of carbamoyl benzotriazoles were also explored.
Mao Hui +5 more
doaj +1 more source
Approaches towards the synthesis of 5-aminopyrazoles
Beilstein Journal of Organic Chemistry, 2011 The biological and medicinal properties of 5-aminopyrazoles have prompted enormous research aimed at developing synthetic routes to these heterocyles. This review focuses on the biological properties associated with this system. Various synthetic methods
Ranjana Aggarwal +3 more
doaj +1 more source
Synthesis of aza-phenylalanine, aza-tyrosine, and aza-tryptophan precursors via hydrazine alkylation; pp. 168–178 [PDF]
Proceedings of the Estonian Academy of Sciences, 2015 Aza-amino acid precursors with an aromatic side chain were synthesized using hydrazine alkylation. This synthetic pathway avoided use of hydrogen gas and expensive hydrogenation catalysts. For the optimization of this alkylation reaction various solvents
Anton Mastitski +3 more
doaj +1 more source