Results 101 to 110 of about 24,483 (218)
Mechanochemistry as an Emerging Tool for Organofluorine Chemistry
Chemistry–Methods, Volume 6, Issue 8, August 2026.Fluorinated scaffolds are central across many areas of chemistry, driving the demand for efficient and sustainable synthetic methods. Mechanochemistry has emerged as a powerful alternative to conventional approaches, offering reduced environmental impact, shorter reaction times, and unique reactivity and selectivity.
Marie Caldiero +3 more
wiley +1 more source
Comprehensive Physiology, Volume 16, Issue 4, August 2026.ERβ activation restores glucose and lipid homeostasis by remodeling the hepatic lipidome. Mechanistically, it promotes complete fatty acid oxidation and decreases Acetyl‐CoA levels, leading to reduced ketogenesis and lipotoxicity, as demonstrated through in vivo and in vitro approaches.
Debora Santos Rocha +9 more
wiley +1 more source
Main Group Metals in Redox Catalysis
European Journal of Inorganic Chemistry, Volume 29, Issue 22, 1 August 2026.Main group metal redox catalysis is emerging as a credible alternative to transition metal chemistry. Elements from groups 13 to 15 now enable diverse catalytic manifolds, driven by ligand design and control of electronic structure. This review highlights recent advances, key design principles, and remaining challenges, positioning main group metals as
Olympia Mouriki +2 more
wiley +1 more source
Antibody–Drug Conjugates and Peptide–Drug Conjugates: Current Understandings and Future Perspectives
MedComm, Volume 7, Issue 8, August 2026.The graphic summarizes the design principles, intracellular trafficking, clinical progress, challenges, and future directions of antibody–drug conjugates (ADCs) and peptide–drug conjugates (PDCs). ADCs consist of a tumor‐targeting antibody, a chemical linker, and a potent payload, whereas PDCs use peptide ligands to deliver cytotoxic, radionuclide, or ...
Ruxi Zheng +9 more
wiley +1 more source
DNA‐Enzyme Hybrid Nanostructures: Functional Materials to Modulate Enzymatic Activity
Small, Volume 22, Issue 43, 3 August 2026.DNA–enzyme hybrid nanostructures enable precise spatial and stoichiometric control over enzyme organization, offering a powerful platform to modulate catalytic activity. This review critically evaluates key mechanistic hypotheses, including proximity effects, microenvironment changes, confinement, and stabilization, as well as highlighting ...
Manar Elnaggar, Amelie Heuer‐Jungemann
wiley +1 more source
British Journal of Pharmacology, Volume 183, Issue 16, Page 4512-4531, August 2026.The G protein–coupled receptor (GPCR) superfamily consists of the most common targets of approved drugs. Targeting GPCRs offers appealing avenues for therapeutic development. Antibodies and their fragments, such as single‐domain antibodies (VHHs or nanobodies), have emerged as useful alternatives to small molecule pharmacophores as building blocks in ...
Shivani Sachdev, Ross W. Cheloha
wiley +1 more source
Recent Advances in Conjugation Chemistry Expanding the Applications of the DNA Tetrahedron
Chemical Biology &Drug Design, Volume 108, Issue 2, August 2026.The tetrahedral DNA nanostructure (TDN) is a promising drug delivery and biosensing platform that can be chemically modified with absolute payload precision. This review highlights explicit conjugation chemistries driving functionalization of the TDN for a broad range of applications, advancing its role in support of next‐generation biomimetic ...
Tyler J. Rutherford +1 more
wiley +1 more source
Human Pharmacokinetic Prediction of Antibody‐Drug Conjugates Using Human FcRn Transgenic Mice
Clinical and Translational Science, Volume 19, Issue 8, August 2026.ABSTRACT Antibody‐drug conjugates (ADCs) have progressed significantly in recent years, particularly in the oncology field. However, predicting human pharmacokinetics (PK) of ADCs in the early stages of drug development remains challenging. Human neonatal Fc receptor (FcRn) transgenic mice have been established as a reliable pre‐clinical PK model for ...
Keitaro Nakagawa, Kenta Haraya
wiley +1 more source
Substrate‐specific mitochondrial dysfunction and metabolomic profiles in type 2 diabetic rat hearts
Experimental Physiology, Volume 111, Issue 8, Page 3635-3647, 1 August 2026.Abstract Type 2 diabetes (T2D) greatly alters cardiac fuel handling, yet how mitochondrial function adapts to the diabetic substrate environment remains unclear. This study investigated substrate‐specific cardiac mitochondrial bioenergetics from a T2D rat model induced by a high‐fat diet and low‐dose streptozotocin.
Toan Pham
wiley +1 more source
Employing Nanotechnology to Enhance Ethanol Production in Two Synechococcus elongatus Strains
ChemBioChem, Volume 27, Issue 14, 29 July 2026.Here, we report on how bacterial microcompartment technology can be used to improve bioproduction in cyanobacteria. Fusion of encapsulation peptides to the two enzymes of the ethanol biosynthetic pathway increased ethanol titres up to 84 times. 1.31 g L−1 of ethanol was produced in 6 days.
Alexandra M. Schirmacher +3 more
wiley +1 more source