Results 71 to 80 of about 10,821 (234)
Angewandte Chemie, EarlyView.An optimized strategy for the ribosomal synthesis of thioisoindole‐bridged bicyclic (TiB) peptides is incorporated into the RaPID platform, enabling high‐throughput discovery from topologically defined TiB libraries. Proof‐of‐concept selection against TNIK identifies nanomolar‐affinity ligands with inhibitory activity, while x‐ray crystallography ...
Yue Zhang +5 more
wiley +2 more sources
, 2014 Citation: 'hydrazones' in the IUPAC Compendium of Chemical Terminology, 3rd ed.; International Union of Pure and Applied Chemistry; 2006. Online version 3.0.1, 2019. 10.1351/goldbook.H02884 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
openaire +1 more source
Hydrazone-Based Amphiphilic Brush Polymer for Fast Endocytosis and ROS-Active Drug Release
Due to the high reactivity of reactive oxygen species (ROS), it is essential to sweep them away in time. In this study, ClO–-responsible amphiphilic brush polymers were prepared by free radical polymerization using two monomers consisting of polyethylene
Ruhui Yang (15366532) +5 more
core +1 more source
Advanced Science, EarlyView.Biomarker‐triggered nanoplatforms transform sepsis therapy by coupling pathological sensing with precision drug release. This review reveals how microenvironment‐responsive nanomedicines enable stage‐specific intervention, improve therapeutic efficacy, and minimize systemic toxicity, while highlighting emerging opportunities for AI‐assisted and ...
Yukun Liu +7 more
wiley +1 more source
Cobalt‐Catalyzed C─N Bond Formation via Metal‐Hydride Hydrogen Atom Transfer (MHAT)
Angewandte Chemie, EarlyView.Cobalt‐catalyzed metal‐hydride hydrogen atom transfer (Co‐MHAT) converts simple alkenes into C─N bonds under mild, near‐neutral conditions. A shared Co─H‐initiated radical/organocobalt intermediate is channeled into radical trapping, radical‐polar crossover, or radical ligand transfer, unifying hydroamination, hydroazidation, hydroamidation, and remote
Arman Khosravi, Ming‐Yu Ngai
wiley +2 more sources
Selective C–H activation of a molecule containing multiple directing groups is an important but challenging issue in organic chemistry. Herein, a combined directing group (hydrazone-oxime) selectively directed [4 + 2] annulation cascade to synthesize ...
Jinhua Wang (1506) +5 more
core +1 more source
The interaction of pyridoxal isonicotinoyl hydrazone (PIH) and salicylaldehyde isonicotinoyl hydrazone (SIH) with iron [PDF]
, 2017 The interaction of pyridoxal isonicotinoyl hydrazone (PIH) and salicylaldehyde isonicotinoyl hydrazone (SIH), two important biologically active chelators, with iron has been investigated by spectrophotometric methods.
Hider, Robert C. +7 more
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Advanced Science, EarlyView.Nebulized BN@NF nanozymes integrate boron nanosheets with Nd‐doped iron phosphide to form a sono‐magneto‐responsive Z‐scheme heterostructure. Under ultrasound and magnetic activation, BN@NF amplifies ROS generation, eradicates bacteria, disrupts biofilms, and reshapes pulmonary inflammation through NF‐κB suppression, mitophagy promotion, and M1‐to‐M2 ...
Xiaofeng Luo +6 more
wiley +1 more source
Smart Bioinks for 4D Bioprinting: Requirements, Design, and Applications
Advanced Science, EarlyView.Smart bioinks empower 4D‐bioprinted constructs to dynamically adapt and remodel in response to stimuli, effectively biomimicking native tissues. Artificial Intelligence (AI) and Machine Learning (ML) play a guiding role in their rational design by optimizing relevant properties.
Shangsi Chen +11 more
wiley +1 more source
Síntese de derivados N-acilidrazônicos com potencial atividade antiparasitária [PDF]
, 2012 Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Físicas e Matemáticas. Programa de Pós-Graduação em Química.Uma série de N-{[(5-substituído)-furan-2-il]-metilideno}-piridina-2-carboidrazidas funcionalizadas na posição ...
Raitz, Ismael
core