Results 51 to 60 of about 8,645 (211)

Synthesis and Development of N-2,5-Dimethylphenylthioureido Acid Derivatives as Scaffolds for New Antimicrobial Candidates Targeting Multidrug-Resistant Gram-Positive Pathogens

Antibiotics, 2023
The growing antimicrobial resistance to last-line antimicrobials among Gram-positive pathogens remains a major healthcare emergency worldwide. Therefore, the search for new small molecules targeting multidrug-resistant pathogens remains of great ...
Povilas Kavaliauskas, Birutė Grybaitė, Rita Vaickelionienė, Birutė Sapijanskaitė-Banevič, Kazimieras Anusevičius, Agnė Kriaučiūnaitė, Gabrielė Smailienė, Vidmantas Petraitis, Rūta Petraitienė, Ethan Naing, Andrew Garcia, Vytautas Mickevičius   +11 more
doaj   +1 more source

Negotiating in a Foreign Land: Understanding the Curious Interactions Between Intracellular Mitochondria and Internalized Nanoparticles

Advanced Materials Interfaces, EarlyView.
Therapeutic nano‐drug delivery systems interact with cellular mitochondria in a multitude of ways. While the complexity of such interactions disrupts the mitochondrial electron transport chain and increases reactive oxygen species production, thereby contributing to nanoparticle toxicity, they also present unique theranostic opportunities in diseases ...
Sourav Bhattacharjee
wiley   +1 more source

Discovery of potent 4-aminoquinoline hydrazone inhibitors of NRH:quinoneoxidoreductase-2 (NQO2) [PDF]

, 2019
(NRH):quinone oxidoreductase 2 (NQO2) is associated with various processes involved in cancer initiation and progression probably via the production of ROS during quinone metabolism.
Hussein, Buthaina, Stratford, Ian J., Halbert, Gavin, Freeman, Sally, Kadirvel, Manikandan, Kadirvel, Manikandan; id_orcid, Magwaza, Rachael N., Ikhmais, Balqis, Bryce, Richard A.   +8 more
core   +1 more source

Artemia salina toxicity test of hydrazone H5. [PDF]

, 2021
Artemia salina toxicity test of hydrazone H5.
Arlan de Assis Gonsalves (11752026), Jackson Roberto Guedes da Silva Almeida (7473914), Mariana Gama e Silva (5570888), Érica Martins de Lavor (5570891), Luciano Augusto de Araújo Ribeiro (9583159), Harold Hilarion Fokoue (11752023), Maria Alice Miranda Bezerra Medeiros (11752002), Jussara de Jesus Silva (11752020), Cleônia Roberta Melo Araújo (4869559), Cícero André Ferreira Macedo (11752011), Thiala Alves Feitosa (11752017), Jackson de Menezes Barbosa (11752005), Tiago Feitosa Ribeiro (11752008), Luiz Antonio Miranda de Souza Duarte-Filho (11752014)   +13 more
core   +1 more source

Synthesis of E-Isomer of α-Hydrazone Phosphonates via Nucleophilic Addition of Trialkyl Phosphite to Nitrile Imines (NIs) and DFT Calculations

Journal of Advanced Research in Natural and Applied Sciences
Nitrile imines (NIs) belong to the nitrilium betaine family of 1,3-dipoles. Due to their high reactivity, NI compounds cannot be isolated and must be generated in situ before undergoing the desired transformation.
Sıdıka Polat Çakır, Sinem Altınışık   +1 more
doaj   +1 more source

Clean Grinding Technique: A Facile Synthesis and In Silico Antiviral Activity of Hydrazones, Pyrazoles, and Pyrazines Bearing Thiazole Moiety against SARS-CoV-2 Main Protease (M^pro)

Molecules, 2020
A novel series of some hydrazones bearing thiazole moiety were generated via solvent-drop grinding of thiazole carbohydrazide 2 with various carbonyl compounds.
Sraa Abu-Melha, Mastoura M. Edrees, Sayed M. Riyadh, Mohamad R. Abdelaziz, Abdo A. Elfiky, Sobhi M. Gomha   +5 more
doaj   +1 more source

Synthesis of New Methoxy Actived Mono and Bis-indole Compounds

Hittite Journal of Science and Engineering, 2022
An indole hydrazone has successfully been synthesized employing Schiff base reaction conditions starting from 4,6-dimethoxy-2,3-diphenylindole-7-carbaldehyde with hydrazine hydrate.
Hakan Kandemir
doaj   +1 more source

A Molecular Engineering Strategy to Fine‐Tune Phototoxicity of AIE Probes for Super‐Resolution Imaging of Mitochondrial Cristae Dynamics

Advanced Science, EarlyView.
Regulation of molecular packing, phototoxicity, and ROS output of AIE photosensitizers is achieved through carboxylation and alkyl‐chain‐length tuning. The probe designed via this strategy enables super‐resolution visualization of inner‐mitochondrial‐membrane cristae dynamics under controlled oxidative stress, and fluorescence‐lifetime imaging of ...
Kongqi Chen, Mengjie Wang, Chuen Kam, Zhiming Wang, Qinrong Zhang, Sijie Chen   +5 more
wiley   +1 more source

Design, Synthesis and Structural Characterization of a Novel Asymmetric Hydrazone-Thiosemicarbazone Ligand with the Aim of Obtaining Interesting Metallosupramolecular Architectures

Chemistry Proceedings, 2021
The asymmetric hydrazone-thiosemicarbazone ligand H2L was synthesized in two stages by means of a double-condensation reaction. The potentially dianionic and pentadentate [N3SO] organic ligand H2L possesses two flexible bidentate [NS/NO] domains ...
Sandra Fernández-Fariña, Isabel Velo-Heleno, Miguel Martínez-Calvo, Ana M. González-Noya, Rosa Pedrido   +4 more
doaj   +1 more source

H2S‐Amplified “Three‐in‐One” Antibacterial Strategy for Periodontitis Treatment Using a Photosensitive Pillararene‐Embedded COF/MOF Hybrid

Advanced Science, EarlyView.
The integration of ROS‐generating systems with H2S depletion strategies effectively overcomes the limitations imposed by endogenous antioxidant defenses on ROS‐based antimicrobial therapies. In this study, the Cu‐MOF is incorporated into pillararene‐embedded COF, achieving a “three‐in‐one” antimicrobial effect that markedly alleviated periodontal ...
Shuang Liang, Meng‐Hao Li, Liang Cheng, Tian‐Shou Zhang, Hui Hui, Yan Wang, Hong‐Pu Zhang, Bo‐Wen Liu, Lin Wang, Ying‐Wei Yang   +9 more
wiley   +1 more source