Results 61 to 70 of about 10,821 (234)

Asymmetric synthesis of 2-substituted oxetan-3-ones via metalated SAMP/RAMP hydrazones [PDF]

, 2013
2-Substituted oxetan-3-ones can be prepared in good yields and enantioselectivities (up to 84% ee) by the metalation of the SAMP/RAMP hydrazones of oxetan-3-one, followed by reaction with a range of electrophiles that include alkyl, allyl, and benzyl ...
Geden, Joanna V., Beasley, Benjamin, Clarkson, Guy J., Shipman, Michael   +3 more
core   +1 more source

Heteroatom‐Mediated Covalent Organic Framework Membranes With Nitrogen‐Enriched Nanochannels for Efficient Desalination

Advanced Science, EarlyView.
Heteroatom precursor engineering serves as a molecular‐level strategy to tailor hydrazide monomer reactivity and diffusion kinetics, enabling controlled assembly of highly crystalline COF membranes with ultramicroporous channels. The nitrogen‐enriched nanochannels deliver high water/ion selectivity via simultaneous water transport acceleration and ion ...
Guishan Hu, Muning Chen, Yunqiu Zhou, Yu Zhen, Miaomiao Tian, Yatao Zhang, Jingwei Hou, Junyong Zhu, Yong Wang   +8 more
wiley   +1 more source

Two Vanadium(V) Complexes Derived from Bromo and Chloro-Substituted Hydrazone Ligands: Syntheses, Crystal Structures and Antimicrobial Property

Acta Chimica Slovenica, 2020
Two vanadium(V) complexes derived from the bromo and chloro-substituted hydrazones N'-(4-bromo-2-hydroxybenzylidene)-2-chlorobenzohydrazide (H2L1) and N'-(3-bromo-5-chloro-2-hydroxybenzylidene)-3-methylbenzohydrazide (H2L2) with the formula [VOL1(OCH3 ...
Zi-Qiang Sun, Shun-Feng Yu, Xin-Lan Xu, Xiao-Yang Qiu, Shu-Juan Liu   +4 more
doaj   +1 more source

Discovery of Novel Thiophene/Hydrazones: In Vitro and In Silico Studies against Pancreatic Cancer

Pharmaceutics, 2023
Cancer is the disease with the highest mortality. Drug studies contribute to promising treatments; however there is an urgent need for selective drug candidates. Pancreatic cancer is difficult to treat and the cancer progresses rapidly.
Goknil Pelin Coskun, Yagmur Ozhan, Vladimir Dobričić, Jelena Bošković, Rengin Reis, Hande Sipahi, Zafer Sahin, Seref Demirayak   +7 more
doaj   +1 more source

Reversing Macrophage Immunometabolic Dysfunction in Prolonged Infections Via a Glutaminolysis‐Fueled Restoration‐Based Hierarchically Selective Therapeutic System

Advanced Science, EarlyView.
A hierarchically selective immunotherapeutic nanoplatform, mGls@HEV‐MTP, selectively restores macrophage immunocompetence through GLS1‐mediated restoration of glutaminolysis‐fueled anaplerosis. Concurrently, it renders Staphylococcus aureus (S. aureus) more readily recognizable to the metabolically reprogrammed macrophages, thereby facilitating ...
Weinan Yang, Zihao An, Honglu Cai, Congsun Li, Jiaxuan Zou, Wushi Cui, Wentao Chen, Tao Zhang, Shicheng Wang, Zizhan Su, Jian Xiao, Tao Sun, Bin Hu, Min Cheng, Zhongru Gou, Jianbin Xu, An Liu, Haobo Wu   +17 more
wiley   +1 more source

3-Hydroxy-N’-(2-hydroxy-4-methoxybenzylidene)benzohydrazide and its isostructural cobalt(II) and nickel(II) complexes: Synthesis, X-ray crystal structures and antibacterial activity

Acta Chimica Slovenica
A new hydrazone compound 3-hydroxy-N’-(2-hydroxy-4-methoxybenzylidene)benzohydrazide (HL) and its isostructural cobalt(II) and nickel(II) complexes [M2Cl2L2(EtOH)2] (M = Co for 1, Ni for 2) were synthesized and characterized by physico-chemical methods ...
Zhong-Lu You, Jia-Yan Dai, Hao-Dong Zhang, Yu-Qun Ye, Jin Mu, Mu-Ji Jike, Yu-Qing Gu   +6 more
doaj   +1 more source

Crystal structure of N′-[4-(dimethylamino)benzylidene]furan-2-carbohydrazide monohydrate

Acta Crystallographica Section E: Crystallographic Communications, 2020
The condensation of 2-furoic hydrazide and 4-dimethyl aminobenzaldehyde in ethanol yielded a yellow solid formulated as the title compound, C14H15N3O2·H2O.
Rokhaya Sylla-Gueye, Ibrahima Elhadji Thiam, James Orton, Simon Coles, Mohamed Gaye   +4 more
doaj   +1 more source

Epigenetic Reactivation of TNFRSF19 Suppresses Mitophagy and Sensitizes Triple‐Negative Breast Cancer to Doxorubicin

Advanced Science, EarlyView.
TNFRSF19 is an epigenetically silenced regulator of mitophagy in triple‐negative breast cancer. TNFRSF19 deficiency activates the TGFBR1–SMAD3–PINK1 axis to promote mitophagy and confer doxorubicin resistance, whereas decitabine‐mediated restoration of TNFRSF19 suppresses mitophagy and enhances doxorubicin sensitivity, revealing a targetable epigenetic–
Shiyang Liu, Chenguang Liu, Weihong Zheng, Xiaofei Tong, Zhengwei Gui, Zonghong Lu, Sun Ieong, Lin Zhang   +7 more
wiley   +1 more source

Site‐Specific Protein Bioconjugation Through Cellular Incorporation of Noncanonical Amino Acids

Angewandte Chemie, EarlyView.
Genetic code expansion (GCE) enables site‐specific installation of noncanonical amino acids containing bioorthogonal conjugation handles, allowing precise, homogeneous protein modification. This review examines the principles of orthogonal translation, surveys the chemistries available for chemoselective labeling, and highlights emerging multi‐site ...
Rahul Sarkar, Manas Joshi, Abhishek Chatterjee   +2 more
wiley   +2 more sources

Biomimetic Scaffold‐Based 3D Models for Decoding Cancer Biology and Advancing Therapy

Advanced Science, EarlyView.
A timeline of the research history of 3D biomimetic scaffold materials and platforms. With advances in biomimetic materials and 3D scaffold technologies, their functional scope has expanded from mimicking basic physical and biochemical properties to increasingly replicating complex pathophysiological processes.
Haitao Zhao, Yuechen Han, Jie Li, Peng Luo, Lin Qi, Zhiwei Xia, Xiaosong Li, Quan Cheng, Chenshen Huang, Wantao Wu, Hao Zhang   +10 more
wiley   +1 more source