Results 131 to 140 of about 126,036 (251)

Design and synthesis of novel hybrids incorporating thiadiazole or thiazole-naphthalene: Anticancer assessment and molecular docking study

Results in Chemistry
To underscore the significance of thiazole and thiadiazole moieties in advancing cancer treatment and support researchers in drug design, we developed a novel series of 1,3,4-thiadiazole and 1,3-thiazole derivatives. These were synthesized by reacting 2-(
Jehan Y. Al-Humaidi, Lamia A. Albedair, Basant Farag, Magdi E.A. Zaki, Yousef E. Mukhrish, Sobhi M. Gomha   +5 more
doaj  

Regioselective Synthesis of 5-Trifluoromethyl 1,2,4-Triazoles via [3 + 2]-Cycloaddition of Nitrile Imines with CF₃CN. [PDF]

Molecules, 2022
Lin B, Zhang Z, Yao Y, You Y, Weng Z.
europepmc   +1 more source

Novel thiazolyl-pyrimidine derivatives as potential anticancer agents: Synthesis, biological evaluation, and molecular docking studies

Results in Chemistry
We synthesized and spectroscopically confirmed a series of 1,3-thiazolyl-pyrimidine derivatives to investigate their potential role in cancer therapy.
Tariq Z. Abolibda, Abdel-Aziz A.A. El-Sayed, Basant Farag, Magdi E.A. Zaki, Abdulwahed Alrehaily, Hossein M. Elbadawy, Ahmad A. Al-Shahri, Saleh R. Alsenani, Sobhi M. Gomha   +8 more
doaj  

Cross-Linked Chitosan/Multi-Walled Carbon Nanotubes Composite as Ecofriendly Biocatalyst for Synthesis of Some Novel Benzil Bis-Thiazoles. [PDF]

Polymers (Basel), 2021
Alshabanah LA, Gomha SM, Al-Mutabagani LA, Abolibda TZ, El-Ghany NAA, El-Enany WAMA, El-Ziaty AK, Ali RS, Mohamed NA.   +8 more
europepmc   +1 more source

Synthesis, characterization, and in silico studies of substituted 2,3-dihydro-1,3,4-thiadiazole derivatives

Results in Chemistry
The reaction of hydrazonoyl halides with different carbodithioate derivatives in the presence of triethylamine was studied, resulting in the synthesis of a series of unsymmetrical azine derivatives with yields ranging from 64 % to 80 %. The structures of
Yasser H. Zaki, Sobhi M. Gomha, Basant Farag, Magdi E.A. Zaki, Ahmed M. Hussein   +4 more
doaj  

Synthesis of antimicrobial azoloazines and molecular docking for inhibiting COVID-19. [PDF]

J Heterocycl Chem, 2021
Muhammad ZA, Farghaly TA, Althagafi I, Al-Hussain SA, Zaki MEA, Harras MF.   +5 more
europepmc   +1 more source

Novel imidazoles from guanylhydrazone: Synthesis, computational, and molecular docking studies as α-amylase inhibitors for type 2 diabetes management

Results in Chemistry
This study reports a facile synthesis of novel imidazole derivatives as potential α-amylase inhibitors for type 2 diabetes management. Starting with readily available precursors (p-chloroacetophenone and aminoguanidine), guanylhydrazone 3 was synthesized
Mohamed G. Badrey, Ahmed A. Elhenawy, Mohammad Mahboob Alam, Syed Nazreen, Magdi E.A. Zaki, Sobhi M. Gomha   +5 more
doaj  

Utility of 6-aza-2-thiothymine in the synthesis of novel [1,2,4]triazolo[4,3-b][1,2,4]triazin-7-one derivatives: synthesis, structure elucidation, molecular docking and in vitro anti-lung cancer activity. [PDF]

RSC Adv
Kamel MG, Sroor FM, Mahmoud K, Shafey HI, Hassaneen HM, Vendier L.   +5 more
europepmc   +1 more source

Solvent-Free Synthesis, In Vitro and In Silico Studies of Novel Potential 1,3,4-Thiadiazole-Based Molecules against Microbial Pathogens. [PDF]

Molecules, 2022
Shehadi IA, Abdelrahman MT, Abdelraof M, Rashdan HRM.   +3 more
europepmc   +1 more source

Synthesis, reactions, antitumor and antimicrobial activity of new 5,6-dihydropyrrolo[2,1-a]isoquinoline chalcones. [PDF]

BMC Chem
Teleb MAM, Kamel MG, Mikhail MS, Hassaneen HM, Erian AW, Helmy MT.   +5 more
europepmc   +1 more source