Results 111 to 120 of about 96,281 (281)

The Pathway to Proof‐of‐Concept for BNC210, a Negative Allosteric Modulator of the Alpha‐7 Nicotinic Acetylcholine Receptor (nAChR), for Treatment of Psychiatric Disease

Clinical Pharmacology in Drug Development, EarlyView.
Abstract BNC210 is an investigational small molecule selective negative allosteric modulator of the alpha‐7 nicotinic acetylcholine receptor (α7 nAChR). It is an anxiolytic compound with a novel mechanism of action. In a series of Phase 1 clinical trials in healthy volunteers, psychometric test batteries showed that BNC210 did not cause attention ...
Paul Rolan, Elizabeth Doolin, Dharam Paul, Julia Crossman, Michael Odontiadis, Philippe Danjou, Mark Smith, Spyros Papapetropoulos   +7 more
wiley   +1 more source

Comparative Efficacy of Dexamethasone versus Hydrocortisone in Severe Acute Pediatric Asthma

Iranian Journal of Allergy, Asthma and Immunology, 2007
This study aimed to compare the efficacy of dexamethasone and hydrocortisone in the treatment of acute paediatric asthma. Forty seven asthmatic children were randomised to receive either dexamethasone (0.6 mg/ml, maximum 16 mg) in a single dose or ...
Sedigheh Ebrahimi Bahador Sarkari
doaj  

Effect of Injection of Hydrocortisone into Nerves Thickened by Leprosy

, 1964
W. H. JENNINGS
openalex   +1 more source

A Phase 1, Randomized, Placebo‐Controlled, Multiple‐Dose, Double‐Blind Study to Evaluate and Compare the Pharmacokinetics and Safety of Rimegepant in Healthy Adult Japanese and Caucasian Individuals

Clinical Pharmacology in Drug Development, EarlyView.
Abstract This Phase 1, randomized, placebo‐controlled, double‐blind study assessed the pharmacokinetic profile of rimegepant (25, 75, or 150 mg once daily for 14 days) in healthy Japanese and Caucasian adults. Exposures were modestly increased in Japanese participants compared with Caucasian participants following a single dose of rimegepant (Day 1 ...
Rajinder Bhardwaj, Chay Ngee Lim, Yinhua Li, Kyle T. Matschke, Richard Bertz, Robert Croop, Jing Liu   +6 more
wiley   +1 more source

Correlation between C-reactive protein, intravenous hydrocortisone, systemic tranexamic acid and post mastectomy seroma

, 2021
AymanA Albatanony, Ahmed M. A. Assar, Mohammed A. E. El Balshy   +2 more
openalex   +2 more sources

Single I.V.-ketamine Augmentation of Newly Initiated Venlafaxine Hydrocortisone for Treatment-resistant Depression: Randomized, Double-blind Controlled Study Protocol [PDF]

, 2022
Du Yun, Ruobing Feng, Wenle Zhang, Jiexin Fang, Ke Ma, Encong Wang, Yongdong Hu   +6 more
openalex   +1 more source

Cystatin C‐based eGFR better predicts renal vancomycin clearance than creatinine‐based eGFR in patients with allogeneic stem cell transplantation

Clinical Pharmacology &Therapeutics, EarlyView.
Knowledge of the glomerular filtration rate (GFR) is mandatory when dosing renally eliminated drugs such as vancomycin. In clinical practice, different biomarkers and various equations are used to estimate GFR (eGFR), resulting in varying estimates.
Eva‐Maria A. Wansing, Sebastian G. Wicha, Peter Bannas, Alexander Heitkamp, Adrin Dadkhah, Nicolaus M. Kröger, Isabel Molwitz, Claudia Langebrake   +7 more
wiley   +1 more source

DSOK‐0011 Potentially Regulates Circadian Misalignment and Affects Gut Microbiota Composition in Activity‐Based Anorexia Model

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Anorexia nervosa (AN) is a metabolic‐psychiatric disorder characterized by severe weight loss, hypercortisolemia, and hypothalamic–pituitary–adrenal (HPA) axis activation. In this study, we investigated the effect of inhibiting cortisol regeneration via the enzyme 11β‐hydroxysteroid dehydrogenase type 1 (11β‐HSD1) on the ...
Hiroki Kawai, Nanami Wada, Shinji Sakamoto, Kenji Miyazaki, Taro Kato, Yoshihiro Horiuchi, Hiroshi Kirii, Hoang Duy Nguyen, Kenji Hinotsu, Yoshio Ohya, Takahiro Asada, Akiyoshi Yokode, Yuko Okahisa, Haruko Miyazaki, Toshitaka Oohashi, Manabu Takaki   +15 more
wiley   +1 more source

Preliminary Evidence of the Association Between Binge Eating and Preeclampsia in Pregnant U.S. Military Active‐Duty Service Women

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objectives Binge eating is the most common disordered eating behavior among pregnant women. This study examined the association of binge‐eating frequency with the presence of a self‐reported current preeclampsia diagnosis in a sample of U.S. military active‐duty Service women. Methods Active‐duty Service women (N = 134), 20–27 weeks gestation,
Ruby Schrag, Jason M. Lavender, Autumn Mains, Stephanie Rioux, Isabel Thorstad, Zoe Sinkford, Victoria Thomas, David A. Klein, Mark Haigney, Marian Tanofsky‐Kraff, Katherine A. Thompson   +10 more
wiley   +1 more source

Resistance to therapy in mature palmerston north mice treated with cyclophosphamide or hydrocortisone sodium succinate

, 1980
Sara E. Walker, Bertram Schnitzer
openalex   +2 more sources