Results 111 to 120 of about 164,153 (386)

Prospective evaluation of low-dose ketoconazole plus hydrocortisone in docetaxel pre-treated castration-resistant prostate cancer patients. [PDF]

, 2015
BackgroundKetoconazole is a well-known CYP17-targeted systemic treatment for castration-resistant prostate cancer (CRPC). However, most of the published data has been in the pre-chemotherapy setting; its efficacy in the post-chemotherapy setting has not ...
Beckett, LA, Lara, PN, Lo, EN, Pan, CX, Robles, D, Sands, JM, Suga, JM   +6 more
core  

Rationale for Prolonged Glucocorticoid Use in Pediatric ARDS: What the Adults Can Teach Us. [PDF]

, 2016
Based on molecular mechanisms and physiologic data, a strong association has been established between dysregulated systemic inflammation and progression of acute respiratory distress syndrome (ARDS).
Meduri, Gianfranco Umberto, Schwingshackl, Andreas   +1 more
core   +1 more source

De Novo Design of Integrin α5β1 Modulating Proteins to Enhance Biomaterial Properties

Advanced Materials, EarlyView.
NeoNectins are de novo‐designed miniproteins that selectively bind and stabilize the extended open form of integrin α5β1. When grafted onto biomaterials including hydrogel and titanium, they promote cell attachment and spreading in vitro and promoting tissue integration and bone growth in animal models, demonstrating broad potential for regenerative ...
Xinru Wang, Jordi Guillem‐Marti, Saurav Kumar, David S. Lee, Daniel Cabrerizo‐Aguado, Rachel Werther, Kevin Alexander Estrada Alamo, Yan Ting Zhao, Adam Nguyen, Irina Kopyeva, Buwei Huang, Jing Li, Yuxin Hao, Xinting Li, Aritza Brizuela‐Velasco, Analisa Murray, Stacey Gerben, Anindya Roy, Cole A. DeForest, Timothy Springer, Hannele Ruohola‐Baker, Jonathan A. Cooper, Melody G. Campbell, Jose Maria Manero, Maria‐Pau Ginebra, David Baker   +25 more
wiley   +1 more source

Activity of different desoximetasone preparations compared to other topical corticosteroids in the vasoconstriction assay [PDF]

, 2008
Introduction: We report on a double-blind, vehicle-controlled, single-center confirmatory study with random assignment. The purpose of the study was to investigate the topical bioavailability of different topical corticosteroid formulations in healthy ...
Ashton RE, C. Borelli, Gorne RC, H.C. Korting, Hebert AA, Henry M, J. Gassmueller, J.W. Fluhr, K.H. Nietsch, Korting HC, Krochmal L, Luger T, McKenzie A, Morgan JF, S. Schinzel, Savin RC, Seidenari S, Woodford R   +17 more
core   +1 more source

Formulation of Carbopol®/Poly(2-ethyl-2-oxazoline)s Mucoadhesive Tablets for Buccal Delivery of Hydrocortisone

Polymers, 2018
Poly(2-ethyl-2-oxazoline) has become an excellent alternative to the use of poly(ethylene glycol) in pharmaceutical formulations due to its valuable physicochemical and biological properties. This work presents a formulation of poorly-water soluble drug,
L. Ruiz‐Rubio, M. L. Alonso, L. Pérez-Álvarez, R. Alonso, J. Vilas, V. Khutoryanskiy   +5 more
semanticscholar   +1 more source

Artesunate Nanoplatform Targets the Serine–MAPK Axis in Cancer‐Associated Fibroblasts to Reverse Photothermal Resistance in Triple‐Negative Breast Cancer

Advanced Materials, EarlyView.
The artesunate nanoplatform selectively targets ECM CAF, functioning as a GTPase inhibitor through disruption of intracellular serine homeostasis. This metabolic intervention effectively suppresses MAPK cascade activity, which consequently inhibits PTT‐induced CAF to ECM CAF differentiation.
Dongdong Zheng, Jiaqi Yan, Xuejiao Liu, Zhiming Zhang, Anqi Jin, Yue Zhao, Lu Bai, Mengyao Quan, Xiuzhu Qi, Bin Fu, Zhigang Wu, Jin Zhou, Han Han, Ziqi Wang, Shiyu Wang, Chaoqiang Deng, Weijian Sun, Cai Chang, Shichong Zhou, Hongbo Zhang   +19 more
wiley   +1 more source

Hydrocortisone treatment is associated with early recovery from severe septic shock in patients with obstructive pyelonephritis due to upper urinary tract stone

BJUI Compass
Objectives The administration of hydrocortisone in patients with severe septic shock contributes to early recovery in intensive care. The purpose of this study was to evaluate the effect of hydrocortisone on early recovery from severe septic shock in ...
Isamu Otsuka, Koshiro Nishimoto, Taichi Kozako, Katsuhiro Kanemaru, Yasuhiro Yamashita, Toshiyuki Kamoto, Atsuro Sawada   +6 more
doaj   +1 more source

Hypertension and Severe Hypokalemia Associated With Oral Ingestion of Topical Hydrocortisone Cream

AACE Clinical Case Reports, 2023
Background: Topical use of corticosteroids causes systemic effects, but systemic toxicity by ingesting topical corticosteroid cream has not been reported. We describe a patient admitted with ingestion of over-the-counter (OTC) hydrocortisone cream.
Arunava Saha, MD, Suryanarayanan Balakrishnan, MD, Nitin Trivedi, MD, George M. Abraham, MD, MPH, MACP   +3 more
doaj  

Is physiological glucocorticoid replacement important in children? [PDF]

, 2017
Cortisol has a distinct circadian rhythm with low concentrations at night, rising in the early hours of the morning, peaking on waking and declining over the day to low concentrations in the evening.
Arlt, Balsalobre, Bancos, Begum, Bleicken, Browne, Charmandari, Charmandari, Charmandari, Crown, de Weerth, de Weerth, Debono, Debono, DeVile, Diabetes, Dunlap, Dunlop, Désir, Finkielstain, Gagliardi, Gan, Ghizzoni, Gilban, Giordano, Guyon, Han, Han, Hansen, Hastings, Hermida, Hindmarsh, Hindmarsh, Iwata, Joanne Blair, Johannsson, Johannsson, John Porter, Jonetz-Mentzel, Khanna, Knutsson, Kupperman, Lashansky, Leproult, Maguire, Maguire, Mallappa, McClung, Miller, Moreira, Moreira, Moreira, Morris, Peacey, Perry, Peters, Price, Quirós, Reutrakul, Richard J Ross, Santiago, Shirtcliff, Simon, Speiser, Spiegel, Steudte-Schmiedgen, Stroud, Tiemensma, Tuli, Van Cauter, Veldhuis, Vyas, Völkl, Wadhwa, Wallace, Whitaker, Whitaker, White, Williams, Wood, Wright, Zimmermann   +81 more
core   +1 more source

The Role of Artificial Intelligence in Advancing Biosensor Technology: Past, Present, and Future Perspectives

Advanced Materials, EarlyView.
This review explores the transformative role of AI in biosensor technology and provides a holistic interdisciplinary perspective that covers a broader scope of AI‐enabled biosensor technologies across various sectors including healthcare, environmental monitoring, food safety, and agriculture. It also highlights the important role of novel materials in
Tuğba Akkaş, Mahshid Reshadsedghi, Mustafa Şen, Volkan Kılıç, Nesrin Horzum   +4 more
wiley   +1 more source