Results 101 to 110 of about 97,069 (297)

G6PC Downregulation Promotes Renal Calcium Oxalate Stone Formation via Lactate‐Induced SNAIL1 K206 Lactylation and Epithelial‐Mesenchymal Transition

Advanced Science, EarlyView.
In renal calcium oxalate stone formation, G6PC downregulation leads to lactate accumulation. This lactate mediates CBP/p300‐dependent lactylation of SNAIL1 at K206, promoting its nuclear translocation. Nuclear SNAIL1 activates the TGF‐β/SMAD3 pathway, driving epithelial‐mesenchymal transition and fibrosis, which ultimately facilitates crystal ...
Kai Liu, Boming Zhang, Ruixin Fan, Chen Duan, Yangjun Zhang, Huahui Wu, Xiangyang Yao, Xiongmin Mao, Bo Li, Youmiao Zeng, Zhenzhen Xu, Yang Wang, Mengcheng Luo, Xinyu Xu, Ninghan Feng, Heng Li, Hua Xu   +16 more
wiley   +1 more source

In-use Stability of Hydrocortisone Injection Preparations at a Regional Referral Hospital in Central Java

Jurnal Ilmiah Medicamento
Hydrocortisone Sodium Succinate 50mg injection is widely used in perinatology wards. These wards cater to newborns (0-28 days), low birth weight (
Erza Genatrika, Elza Sundhani, Adriana Eka Fitri   +2 more
doaj   +1 more source

Rectal Hydrocortisone [PDF]

BMJ, 1957
J D, NABARRO, A, MOXHAM, G, WALKER, J D, SLATER   +3 more
openaire   +2 more sources

Making Sweat Measurable: Induction, Sampling, and Refreshment in Wearable Biofluid Sensing

Advanced Science, EarlyView.
Wearable sweat sensing relies not only on chemical detection but also on controlled biofluid management. This Review integrates sweat physiology, induction strategies, and microfluidic sampling architectures, demonstrating how flux, transport, and refreshment shape measurement reliability.
Soyoung Shin, Wei Gao
wiley   +1 more source

The Effect of Intravenous Hydrocortisone (1 or 2 mg/kg) on Postoperative Shivering in Cesarean Section with Spinal Anesthesia

مجله دانشکده پزشکی اصفهان, 2017
Background: Postoperative shivering is one of the most prevalent complications that several methods were used for controlling it. This study aimed to determine the effect of two doses of intravenous hydrocortisone (1 or 2 mg/kg) on postoperative ...
Azim Honarmand, Mohammadreza Reza Safavi, Anahita Hirmanpour, Soheila Afzali   +3 more
doaj  

The formation and characterization of hydrocortisone-loaded poly((±)-lactide) microspheres

, 1986
The solvent evaporation process has been used to form hydrocortisone-loaded microspheres from poly((±)-lactide) (PLA) and a lactide-glycolide copolymer (65/35). Methylene chloride was the casting solvent.
M Cavalier, J P Benoit, C THIES
core   +1 more source

Engineered Exosomal miR‐146a‐5p Reprograms BMSC Fate and Restores Mitochondrial Homeostasis in Glucocorticoid‐Induced Osteonecrosis of Femoral Head

Advanced Science, EarlyView.
Exosomal miR‐146a‐5p is identified as a pivotal regulator in steroid‐induced osteonecrosis. Its reduction activates NF‐κB signaling, compromises mitophagy, and disrupts mitochondrial bioenergetics, resulting in autophagic disequilibrium. Engineered exosomes delivering miR‐146a‐5p reinstate mitochondrial function, augment oxidative phosphorylation and ...
Zehui Lv, Xuejie Cai, Yiming Xu, Xingdong Yang, Ruoying Wang, Han Wang, Yixin Bian, Jiawei Xu, Jiao Lu, Lulu Liu, Yingjie Wang, Jibin Song, Bin Feng, Xisheng Weng   +13 more
wiley   +1 more source

Role of hydrocortisone in prevention of pain on propofol injection

Journal of Anaesthesiology Clinical Pharmacology, 2011
Background and Objectives : Pain following intravenous injection of propofol continues to be an intriguing problem. None of the commonly used methods completely attenuate the pain. Inflammatory response to propofol contributes to the pain.
Monu Yadav, Padmaja Durga, R Gopinath
doaj   +1 more source

Secondary adrenal insufficiency: From the physiopathology to the possible role of modified-release hydrocortisone treatment

, 2018
due to an impairment production of adrenocorticotropic hormone (ACTH). In particular, secondary AI results from pituitary disease that impedes the release of ACTH, while tertiary AI is caused from an impaired synthesis of corticotropinreleasing hormone ...
Corsello, Salvatore M., Paragliola, Rosa M.   +1 more
core   +1 more source

Pharmacological Inhibition of FKBP51 Mitigates Early Life Adversity‐Induced Social Deficits in Male Mice

Advanced Science, EarlyView.
Early life adversity triggers persistent social subordination and brain‐wide molecular dysregulation. Pharmacological inhibition of the stress‐mediator FKBP51 during the adversity period prevents these long‐term deficits and restores normative social hierarchy.
Joeri Bordes, Xiuqi Ji, Serena Gasperoni, Choham Sudre‐Chinsky, Amirali Kalbasi, Daniela Harbich, Cornelia Flachskamm, Paula Fontanet, Sowmya Narayan, Manfred Uhr, Christian Namendorf, Camilla Bellone, Alon Chen, Felix Hausch, Juan Pablo Lopez, Mathias V. Schmidt   +15 more
wiley   +1 more source